Ankrd26 ankyrin repeat domain 26 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ankrd26provided by MGI
Official Full Name: ankyrin repeat domain 26provided by MGI
Primary source: MGI:MGI:1917887
See related: Ensembl:ENSMUSG00000007827 AllianceGenome:MGI:1917887
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA1074; 5730521P14Rik
Summary: Involved in negative regulation of fat cell differentiation. Acts upstream of or within several processes, including glucose homeostasis; negative regulation of organ growth; and negative regulation of signal transduction. Located in actin cytoskeleton. Used to study obesity. Human ortholog(s) of this gene implicated in thrombocytopenia. Orthologous to several human genes including ANKRD26 (ankyrin repeat domain 26). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in CNS E11.5 (RPKM 6.4), CNS E14 (RPKM 3.8) and 19 other tissues See more
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Genomic context

Location:: 6 F1; 6 55.86 cM

Exon count:: 35

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (118478261..118539244, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (118501300..118562280, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the methylation of specific CpGs at the Ankrd26 promoter occurs in mice during HFD treatment and causes the down-regulation of Ankrd26 expression, at least in part, by impairing p300 binding to its promoter. We propose that the epigenetic silencing of the Ankrd26 gene contributes to VAT inflammation following unhealthy dieting.
Title: Specific CpG hyper-methylation leads to Ankrd26 gene down-regulation in white adipose tissue of a mouse model of diet-induced obesity.
Deletion of the C-terminus of the protein encoded by Ankrd26 leads to changes in primary cilia in the brain, resulting in the disruption of the function of the melanocortin pathway and the HPA axis and leading to excessive food intake and obesity.
Title: A novel form of ciliopathy underlies hyperphagia and obesity in Ankrd26 knockout mice.
Data indicate that Ankrd26 is involved in regulation of food intake and in regulation of insulin/insulin receptor signaling in white adipose tissue; partial inactivation of Ankrd26 leads to obesity and, thus, to diabetes type 2.
Title: Partial inactivation of Ankrd26 causes diabetes with enhanced insulin responsiveness of adipose tissue in mice.
conclude that Ankrd26 gene disruption promotes adipocyte differentiation at both the progenitor commitment and differentiation steps and that ERK activation plays a role in this process
Title: Ankrd26 gene disruption enhances adipogenesis of mouse embryonic fibroblasts.
obesity and gigantism may be caused by a disruption of the Ankrd26 gene
Title: A model for obesity and gigantism due to disruption of the Ankrd26 gene.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of organ growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of organ growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of fatty acid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of lipid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ankyrin repeat domain-containing protein 26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081112.2 → NP_001074581.1 ankyrin repeat domain-containing protein 26

Status: VALIDATED

Source sequence(s)

AC036121, AC140192

Consensus CDS

CCDS39609.1

UniProtKB/Swiss-Prot

Q69ZS2, Q811D2, Q9CS61

UniProtKB/TrEMBL

D3Z482

Related

ENSMUSP00000108449.2, ENSMUST00000112830.3

Conserved Domains (8) summary

COG1340
Location:1197 → 1457

COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]

cd00204
Location:75 → 200

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12001
Location:1495 → 1602

DUF3496; Domain of unknown function (DUF3496)

pfam12796
Location:85 → 177

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:51 → 101

Ank_4; Ankyrin repeats (many copies)

pfam14915
Location:886 → 1189

CCDC144C; CCDC144C protein coiled-coil region

sd00045
Location:82 → 111

ANK; ANK repeat [structural motif]

cl21509
Location:1195 → 1329

ApoLp-III_like; Apolipophorin-III and similar insect proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

118478261..118539244 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006506023.4 → XP_006506086.1 ankyrin repeat domain-containing protein 26 isoform X2

UniProtKB/Swiss-Prot

Q69ZS2, Q811D2, Q9CS61

Conserved Domains (6) summary

PLN03192
Location:54 → 277

PLN03192; Voltage-dependent potassium channel; Provisional

COG1196
Location:690 → 1521

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

sd00045
Location:82 → 111

ANK; ANK repeat [structural motif]

pfam12001
Location:1462 → 1569

DUF3496; Domain of unknown function (DUF3496)

pfam12796
Location:85 → 177

Ank_2; Ankyrin repeats (3 copies)

pfam14915
Location:853 → 1156

CCDC144C; CCDC144C protein coiled-coil region
XM_006506022.4 → XP_006506085.1 ankyrin repeat domain-containing protein 26 isoform X1

UniProtKB/Swiss-Prot

Q69ZS2, Q811D2, Q9CS61

Conserved Domains (6) summary

PLN03192
Location:54 → 277

PLN03192; Voltage-dependent potassium channel; Provisional

COG1196
Location:728 → 1559

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

sd00045
Location:82 → 111

ANK; ANK repeat [structural motif]

pfam12001
Location:1500 → 1607

DUF3496; Domain of unknown function (DUF3496)

pfam12796
Location:85 → 177

Ank_2; Ankyrin repeats (3 copies)

pfam14915
Location:891 → 1194

CCDC144C; CCDC144C protein coiled-coil region
XM_036166065.1 → XP_036021958.1 ankyrin repeat domain-containing protein 26 isoform X6

Conserved Domains (3) summary

COG1196
Location:305 → 1136

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam12001
Location:1077 → 1184

DUF3496; Domain of unknown function (DUF3496)

pfam14915
Location:468 → 772

CCDC144C; CCDC144C protein coiled-coil region
XM_036166064.1 → XP_036021957.1 ankyrin repeat domain-containing protein 26 isoform X5

Conserved Domains (3) summary

COG1196
Location:338 → 1169

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam12001
Location:1110 → 1217

DUF3496; Domain of unknown function (DUF3496)

pfam14915
Location:501 → 805

CCDC144C; CCDC144C protein coiled-coil region
XM_030255354.2 → XP_030111214.1 ankyrin repeat domain-containing protein 26 isoform X4

Conserved Domains (3) summary

COG1196
Location:343 → 1174

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam12001
Location:1115 → 1222

DUF3496; Domain of unknown function (DUF3496)

pfam14915
Location:506 → 809

CCDC144C; CCDC144C protein coiled-coil region
XM_006506025.4 → XP_006506088.1 ankyrin repeat domain-containing protein 26 isoform X7

Conserved Domains (3) summary

COG1196
Location:240 → 1071

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam12001
Location:1012 → 1119

DUF3496; Domain of unknown function (DUF3496)

pfam14915
Location:403 → 706

CCDC144C; CCDC144C protein coiled-coil region
XM_006506024.4 → XP_006506087.1 ankyrin repeat domain-containing protein 26 isoform X3

UniProtKB/Swiss-Prot

Q69ZS2, Q811D2, Q9CS61

Conserved Domains (6) summary

PLN03192
Location:54 → 277

PLN03192; Voltage-dependent potassium channel; Provisional

COG1196
Location:660 → 930

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

TIGR02169
Location:1104 → 1300

SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

sd00045
Location:82 → 111

ANK; ANK repeat [structural motif]

pfam12796
Location:85 → 177

Ank_2; Ankyrin repeats (3 copies)

pfam14915
Location:891 → 1194

CCDC144C; CCDC144C protein coiled-coil region