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    Zfp637 zinc finger protein 637 [ Mus musculus (house mouse) ]

    Gene ID: 232337, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Zfp637provided by MGI
    Official Full Name
    zinc finger protein 637provided by MGI
    Primary source
    MGI:MGI:2448537
    See related
    Ensembl:ENSMUSG00000059689 AllianceGenome:MGI:2448537
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Znf32
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in diencephalon lateral wall ventricular layer; medulla oblongata basal plate ventricular layer; midbrain ventricular layer; pons ventricular layer; and telencephalon ventricular layer. Orthologous to human ZNF32 (zinc finger protein 32). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 16.4), CNS E14 (RPKM 16.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    6 F1; 6 55.59 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (117818165..117822917)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (117840588..117845957)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700030F04 gene Neighboring gene STARR-seq mESC enhancer starr_17118 Neighboring gene STARR-seq mESC enhancer starr_17119 Neighboring gene STARR-seq mESC enhancer starr_17120 Neighboring gene gem nuclear organelle associated protein 6, pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:117791080-117791189 Neighboring gene zinc finger protein 239 Neighboring gene STARR-seq mESC enhancer starr_17123 Neighboring gene predicted gene, 38883 Neighboring gene predicted gene, 38882

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A novel zinc finger protein Zfp637 behaves as a repressive regulator in myogenic cellular differentiation. Li K, et al. J Cell Biochem, 2010 May 15. PMID 20235149
    2. Zinc finger protein 637 protects cells against oxidative stress-induced premature senescence by mTERT-mediated telomerase activity and telomere maintenance. Gao B, et al. Cell Death Dis, 2014 Jul 17. PMID 25032857, Free PMC Article
    3. Exome Sequencing Identifies Genes and Gene Sets Contributing to Severe Childhood Obesity, Linking PHIP Variants to Repressed POMC Transcription. Marenne G, et al. Cell Metab, 2020 Jun 2. PMID 32492392, Free PMC Article
    4. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    5. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The overexpression of Zfp637 markedly increases mTERT expression and telomerase activity, maintains telomere length, and inhibits H2O2 and D-galactose-induced senescence.
      Title: Zinc finger protein 637 protects cells against oxidative stress-induced premature senescence by mTERT-mediated telomerase activity and telomere maintenance.
    2. results suggest that Zfp637 inhibits muscle differentiation through a defect in the cell cycle exit by potentially regulating mTERT expression in C2C12 myoblasts
      Title: A novel zinc finger protein Zfp637 behaves as a repressive regulator in myogenic cellular differentiation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC54806

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zinc finger protein 32

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001346647.2 → NP_001333576.1  zinc finger protein 32 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AC153583, AC153918
      Consensus CDS
      CCDS85139.1
      UniProtKB/Swiss-Prot
      Q80V23
      Related
      ENSMUSP00000108481.2, ENSMUST00000112860.2
      Conserved Domains (2) summary
      COG5048
      Location:60 → 251
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:92 → 112
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_001346648.2 → NP_001333577.1  zinc finger protein 32 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AC153583, AC153918
      Consensus CDS
      CCDS85139.1
      UniProtKB/Swiss-Prot
      Q80V23
      Related
      ENSMUSP00000152569.2, ENSMUST00000223041.2
      Conserved Domains (2) summary
      COG5048
      Location:60 → 251
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:92 → 112
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. NM_001346649.2 → NP_001333578.1  zinc finger protein 32 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate splice site in the 3' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1. Variants 3, 4 and 5 encode the same isoform (2).
      Source sequence(s)
      AC153583, AC153918
      Consensus CDS
      CCDS39607.1
      UniProtKB/Swiss-Prot
      Q3UIS3, Q80V23
      Related
      ENSMUSP00000108482.2, ENSMUST00000112861.8
      Conserved Domains (2) summary
      COG5048
      Location:46 → 237
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:78 → 98
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. NM_001346650.2 → NP_001333579.1  zinc finger protein 32 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site in the 3' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1. Variants 3, 4 and 5 encode the same isoform (2).
      Source sequence(s)
      AC153583, AC153918
      Consensus CDS
      CCDS39607.1
      UniProtKB/Swiss-Prot
      Q3UIS3, Q80V23
      Conserved Domains (2) summary
      COG5048
      Location:46 → 237
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:78 → 98
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. NM_001346651.2 → NP_001333580.1  zinc finger protein 32 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 3, which has a shorter N-terminus, compared to isoform 1. Variants 6, 7 and 8 encode the same isoform (3).
      Source sequence(s)
      AC153583, AC153918
      UniProtKB/TrEMBL
      Q05CR8
      Conserved Domains (2) summary
      COG5048
      Location:21 → 212
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:53 → 73
      ZF_C2H2; C2H2 Zn finger [structural motif]

    6. NM_001346652.2 → NP_001333581.1  zinc finger protein 32 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 3, which has a shorter N-terminus, compared to isoform 1. Variants 6, 7 and 8 encode the same isoform (3).
      Source sequence(s)
      AC153583, AC153918
      UniProtKB/TrEMBL
      Q05CR8
      Conserved Domains (2) summary
      COG5048
      Location:21 → 212
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:53 → 73
      ZF_C2H2; C2H2 Zn finger [structural motif]

    7. NM_001346653.2 → NP_001333582.1  zinc finger protein 32 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 3, which has a shorter N-terminus, compared to isoform 1. Variants 6, 7 and 8 encode the same isoform (3).
      Source sequence(s)
      AC153583, AC153918
      UniProtKB/TrEMBL
      Q05CR8
      Conserved Domains (2) summary
      COG5048
      Location:21 → 212
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:53 → 73
      ZF_C2H2; C2H2 Zn finger [structural motif]

    8. NM_001411605.1 → NP_001398534.1  zinc finger protein 32 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC153583, AC153918

    9. NM_001411609.1 → NP_001398538.1  zinc finger protein 32 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC153583, AC153918
      UniProtKB/Swiss-Prot
      Q3UIS3, Q80V23

    10. NM_001411610.1 → NP_001398539.1  zinc finger protein 32 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC153583, AC153918
      UniProtKB/Swiss-Prot
      Q3UIS3, Q80V23

    11. NM_001411611.1 → NP_001398540.1  zinc finger protein 32 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC153583, AC153918
      UniProtKB/Swiss-Prot
      Q3UIS3, Q80V23

    12. NM_001411613.1 → NP_001398542.1  zinc finger protein 32 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC153583, AC153918
      UniProtKB/TrEMBL
      Q05CR8

    13. NM_001411614.1 → NP_001398543.1  zinc finger protein 32 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC153583, AC153918
      UniProtKB/TrEMBL
      Q05CR8

    14. NM_001411615.1 → NP_001398544.1  zinc finger protein 32 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC153583, AC153918
      UniProtKB/TrEMBL
      Q05CR8

    15. NM_001411616.1 → NP_001398545.1  zinc finger protein 32 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC153583, AC153918
      UniProtKB/TrEMBL
      Q05CR8

    16. NM_001411617.1 → NP_001398546.1  zinc finger protein 32 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC153583, AC153918
      UniProtKB/TrEMBL
      Q05CR8

    17. NM_001411618.1 → NP_001398547.1  zinc finger protein 32 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC153583, AC153918
      UniProtKB/TrEMBL
      Q05CR8

    18. NM_177684.4 → NP_808352.1  zinc finger protein 32 isoform 2

      See identical proteins and their annotated locations for NP_808352.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and uses an alternate splice site in the 3' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1. Variants 3, 4 and 5 encode the same isoform (2).
      Source sequence(s)
      AC153583, AC153918
      Consensus CDS
      CCDS39607.1
      UniProtKB/Swiss-Prot
      Q3UIS3, Q80V23
      Related
      ENSMUSP00000130144.2, ENSMUST00000164472.8
      Conserved Domains (2) summary
      COG5048
      Location:46 → 237
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:78 → 98
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      117818165..117822917
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506017.4 → XP_006506080.1  zinc finger protein 32 isoform X1

      See identical proteins and their annotated locations for XP_006506080.1

      UniProtKB/Swiss-Prot
      Q80V23
      Conserved Domains (2) summary
      COG5048
      Location:60 → 251
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:92 → 112
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. XM_036166061.1 → XP_036021954.1  zinc finger protein 32 isoform X3

      UniProtKB/TrEMBL
      Q05CR8
      Conserved Domains (2) summary
      COG5048
      Location:21 → 212
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:53 → 73
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. XM_030255351.2 → XP_030111211.1  zinc finger protein 32 isoform X2

      UniProtKB/Swiss-Prot
      Q3UIS3, Q80V23
      Conserved Domains (2) summary
      COG5048
      Location:46 → 237
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:78 → 98
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80V23.1 GenPept UniProtKB/Swiss-Prot:Q80V23

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