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    Eva1a eva-1 homolog A, regulator of programmed cell death [ Mus musculus (house mouse) ]

    Gene ID: 232146, updated on 18-Apr-2024

    Summary

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    Official Symbol
    Eva1aprovided by MGI
    Official Full Name
    eva-1 homolog A, regulator of programmed cell deathprovided by MGI
    Primary source
    MGI:MGI:2385247
    See related
    Ensembl:ENSMUSG00000035104 AllianceGenome:MGI:2385247
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fam176a; Tmem166
    Summary
    Predicted to act upstream of or within apoptotic process and autophagy. Predicted to be located in intracellular membrane-bounded organelle and plasma membrane. Is expressed in foot; hand; left lung; renal calyx; and right lung. Orthologous to human EVA1A (eva-1 homolog A, regulator of programmed cell death). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in liver adult (RPKM 20.7), placenta adult (RPKM 16.1) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    6 C3; 6 35.81 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (82018058..82070079)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (82041048..82093099)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 20383 Neighboring gene predicted gene, 32378 Neighboring gene predicted gene, 53287 Neighboring gene predicted gene, 53288 Neighboring gene predicted gene, 40381 Neighboring gene STARR-seq mESC enhancer starr_16424 Neighboring gene predicted gene, 53289

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Knockout of Eva1a leads to rapid development of heart failure by impairing autophagy. Zhang S, et al. Cell Death Dis, 2017 Feb 2. PMID 28151473, Free PMC Article
    2. Quantitative proteomics reveals EVA1A-related proteins involved in neuronal differentiation. Zhong L, et al. Proteomics, 2017 Mar. PMID 28044434
    3. EVA1A (Eva-1 Homolog A) Promotes Endothelial Apoptosis and Inflammatory Activation Under Disturbed Flow Via Regulation of Autophagy. Canham L, et al. Arterioscler Thromb Vasc Biol, 2023 Apr. PMID 36794585, Free PMC Article
    4. Eva1a ameliorates atherosclerosis by promoting re-endothelialization of injured arteries via Rac1/Cdc42/Arpc1b. Li J, et al. Cardiovasc Res, 2021 Jan 21. PMID 31977009
    5. EVA1A/TMEM166 Regulates Embryonic Neurogenesis by Autophagy. Li M, et al. Stem Cell Reports, 2016 Mar 8. PMID 26905199, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. EVA1A (Eva-1 Homolog A) Promotes Endothelial Apoptosis and Inflammatory Activation Under Disturbed Flow Via Regulation of Autophagy.
      Title: EVA1A (Eva-1 Homolog A) Promotes Endothelial Apoptosis and Inflammatory Activation Under Disturbed Flow Via Regulation of Autophagy.
    2. Eva1a ameliorates atherosclerosis by promoting re-endothelialization of injured arteries via Rac1/Cdc42/Arpc1b.
      Title: Eva1a ameliorates atherosclerosis by promoting re-endothelialization of injured arteries via Rac1/Cdc42/Arpc1b.
    3. Eva1a improves cardiac function.
      Title: Knockout of Eva1a leads to rapid development of heart failure by impairing autophagy.
    4. ATP synthesis, oxidative phosphorylation, and the TCA cycle, are involved in the EVA1A regulatory network.EVA1A plays an important role in neuronal differentiation.
      Title: Quantitative proteomics reveals EVA1A-related proteins involved in neuronal differentiation.
    5. EVA1A deletion results in defective self-renewal and differentiation of NSCs. EVA1A modulates autophagy through the PIK3CA/AKT-mTOR pathway.
      Title: EVA1A/TMEM166 Regulates Embryonic Neurogenesis by Autophagy.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    General gene information

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    Homology

    Clone Names

    • MGC25911, MGC37042

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein eva-1 homolog A
    Names
    eva-1 homolog A
    family with sequence similarity 176, member A
    protein FAM176A
    transmembrane protein 166

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001411592.1 → NP_001398521.1  protein eva-1 homolog A

      Status: VALIDATED

      Source sequence(s)
      AC171502
      UniProtKB/Swiss-Prot
      G3X936, Q91WM6

    2. NM_001411593.1 → NP_001398522.1  protein eva-1 homolog A

      Status: VALIDATED

      Source sequence(s)
      AC171502
      UniProtKB/Swiss-Prot
      G3X936, Q91WM6

    3. NM_001411594.1 → NP_001398523.1  protein eva-1 homolog A

      Status: VALIDATED

      Source sequence(s)
      AC171502
      UniProtKB/Swiss-Prot
      G3X936, Q91WM6
      Related
      ENSMUSP00000117345.2, ENSMUST00000149023.2

    4. NM_001411595.1 → NP_001398524.1  protein eva-1 homolog A

      Status: VALIDATED

      Source sequence(s)
      AC171502
      UniProtKB/Swiss-Prot
      G3X936, Q91WM6

    5. NM_145570.3 → NP_663545.2  protein eva-1 homolog A

      See identical proteins and their annotated locations for NP_663545.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the protein. Variants 1-5 all encode the protein.
      Source sequence(s)
      AC171502
      Consensus CDS
      CCDS20261.1
      UniProtKB/Swiss-Prot
      G3X936, Q91WM6
      UniProtKB/TrEMBL
      D3Z511
      Related
      ENSMUSP00000037422.9, ENSMUST00000042974.15
      Conserved Domains (1) summary
      pfam14851
      Location:19 → 156
      FAM176; FAM176 family

    RNA

    1. NR_177292.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC171502
      Related
      ENSMUST00000150691.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      82018058..82070079
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91WM6.2 GenPept UniProtKB/Swiss-Prot:Q91WM6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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