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    Jazf1 JAZF zinc finger 1 [ Mus musculus (house mouse) ]

    Gene ID: 231986, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Jazf1provided by MGI
    Official Full Name
    JAZF zinc finger 1provided by MGI
    Primary source
    MGI:MGI:2141450
    See related
    Ensembl:ENSMUSG00000063568 AllianceGenome:MGI:2141450
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Jaz1; Tip27; C820002C15
    Summary
    Predicted to enable transcription corepressor activity. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II. Predicted to be located in cytosol; fibrillar center; and nucleoplasm. Predicted to be part of transcription repressor complex. Predicted to be active in nucleus. Is expressed in several structures, including gut; nervous system; reproductive system; respiratory system; and sensory organ. Orthologous to human JAZF1 (JAZF zinc finger 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 14.8), CNS E18 (RPKM 12.6) and 13 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    6 B3; 6 25.74 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (52745050..53045613, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (52768065..53068624, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8104 Neighboring gene 60S ribosomal protein L24 pseudogene Neighboring gene Tax1 (human T cell leukemia virus type I) binding protein 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:52767269-52767470 Neighboring gene predicted gene, 52904 Neighboring gene STARR-seq mESC enhancer starr_15910 Neighboring gene STARR-seq mESC enhancer starr_15912 Neighboring gene predicted gene, 52903 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:52862213-52862414 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:52862461-52862666 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:52869251-52869434 Neighboring gene STARR-seq mESC enhancer starr_15913 Neighboring gene STARR-seq mESC enhancer starr_15914 Neighboring gene predicted gene, 33219 Neighboring gene STARR-seq mESC enhancer starr_15915 Neighboring gene dynactin subunit 5 pseudogene Neighboring gene predicted gene, 33097 Neighboring gene STARR-seq mESC enhancer starr_15917 Neighboring gene STARR-seq mESC enhancer starr_15919 Neighboring gene quinolinate phosphoribosyltransferase pseudogene Neighboring gene predicted gene, 57757

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Deletion of Jazf1 gene causes early growth retardation and insulin resistance in mice. Lee HY, et al. Proc Natl Acad Sci U S A, 2022 Dec 6. PMID 36442127, Free PMC Article
    2. JAZF1 heterozygous knockout mice show altered adipose development and metabolism. Jeong J, et al. Cell Biosci, 2021 Aug 19. PMID 34407873, Free PMC Article
    3. Jazf1 acts as a regulator of insulin-producing β-cell differentiation in induced pluripotent stem cells and glucose homeostasis in mice. Park SJ, et al. FEBS J, 2021 Jul. PMID 33555104
    4. Effects of Adenovirus-Mediated Overexpression of JAZF1 on Chronic Inflammation: An In Vitro and In Vivo Study. Meng F, et al. Med Sci Monit Basic Res, 2020 Jul 13. PMID 32655126, Free PMC Article
    5. JAZF1 Inhibits Adipose Tissue Macrophages and Adipose Tissue Inflammation in Diet-Induced Diabetic Mice. Meng F, et al. Biomed Res Int, 2018. PMID 29765984, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Deletion of Jazf1 gene causes early growth retardation and insulin resistance in mice.
      Title: Deletion of Jazf1 gene causes early growth retardation and insulin resistance in mice.
    2. microRNA-19b-3p-containing extracellular vesicles derived from macrophages promote the development of atherosclerosis by targeting JAZF1.
      Title: microRNA-19b-3p-containing extracellular vesicles derived from macrophages promote the development of atherosclerosis by targeting JAZF1.
    3. Effects of Adenovirus-Mediated Overexpression of JAZF1 on Chronic Inflammation: An In Vitro and In Vivo Study.
      Title: Effects of Adenovirus-Mediated Overexpression of JAZF1 on Chronic Inflammation: An In Vitro and In Vivo Study.
    4. The Diabetes Gene JAZF1 Is Essential for the Homeostatic Control of Ribosome Biogenesis and Function in Metabolic Stress.
      Title: The Diabetes Gene JAZF1 Is Essential for the Homeostatic Control of Ribosome Biogenesis and Function in Metabolic Stress.
    5. JAZF1 limits adipose tissue inflammation by limiting macrophage populations and restricting their antigen presentation function.
      Title: JAZF1 Inhibits Adipose Tissue Macrophages and Adipose Tissue Inflammation in Diet-Induced Diabetic Mice.
    6. TIP27 has an important role in glucose homeostasis through the regulation of hepatic glucose metabolism and insulin sensitivity. Furthermore, this regulation requires activation of PI3-kinase.
      Title: Transcription factor TIP27 regulates glucose homeostasis and insulin sensitivity in a PI3-kinase/Akt-dependent manner in mice.
    7. aberrant JAZF1 expression contributes to the oncogenesis and type 2 diabetes pathogenesis
      Title: JAZF1 promotes proliferation of C2C12 cells, but retards their myogenic differentiation through transcriptional repression of MEF2C and MRF4-Implications for the role of Jazf1 variants in oncogenesis and type 2 diabetes.
    8. JAZF1 overexpression decreased serum cholesterol levels and hepatic cholesterol synthesis by inhibiting CREB-dependent HMGCR promoter transcriptional activity.
      Title: Overexpression of JAZF1 protected ApoE-deficient mice from atherosclerosis by inhibiting hepatic cholesterol synthesis via CREB-dependent mechanisms.
    9. JAZF1 plays an important role in lipid metabolism and may thus provide a potential tool for the treatment of obesity and lipid metabolism disorders among other diseases
      Title: JAZF1 regulates visfatin expression in adipocytes via PPARα and PPARβ/δ signaling.
    10. JAZF1 was significantly upregulated during the differentiation of 3T3-L1 preadipocytes. The overexpression of JAZF1 inhibited lipid accumulation in differentiated mature 3T3-L1 adipocytes.
      Title: JAZF1 can regulate the expression of lipid metabolic genes and inhibit lipid accumulation in adipocytes.
    Submit: New GeneRIF Correction See all GeneRIFs (13)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription repressor complex ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    juxtaposed with another zinc finger protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168277.2 → NP_001161749.1  juxtaposed with another zinc finger protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001161749.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC107317, AC117212
      UniProtKB/Swiss-Prot
      Q80ZQ5
      Conserved Domains (1) summary
      COG5189
      Location:105 → 166
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

    2. NM_001411537.1 → NP_001398466.1  juxtaposed with another zinc finger protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC084326, AC107317, AC117212

    3. NM_173406.4 → NP_775582.2  juxtaposed with another zinc finger protein 1 isoform 1

      See identical proteins and their annotated locations for NP_775582.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC084326, AC107317, AC117212
      Consensus CDS
      CCDS20152.1
      UniProtKB/Swiss-Prot
      Q80ZQ5, Q8BLQ8, Q8BWN4
      Related
      ENSMUSP00000074129.6, ENSMUST00000074541.6
      Conserved Domains (1) summary
      COG5189
      Location:169 → 230
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      52745050..53045613 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011241295.2 → XP_011239597.1  juxtaposed with another zinc finger protein 1 isoform X2

      See identical proteins and their annotated locations for XP_011239597.1

      UniProtKB/Swiss-Prot
      Q80ZQ5
      Conserved Domains (1) summary
      COG5189
      Location:105 → 166
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

    2. XM_036166037.1 → XP_036021930.1  juxtaposed with another zinc finger protein 1 isoform X2

      Conserved Domains (1) summary
      COG5189
      Location:105 → 166
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

    3. XM_036166036.1 → XP_036021929.1  juxtaposed with another zinc finger protein 1 isoform X2

      Conserved Domains (1) summary
      COG5189
      Location:105 → 166
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80ZQ5.2 GenPept UniProtKB/Swiss-Prot:Q80ZQ5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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