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    Fam221a family with sequence similarity 221, member A [ Mus musculus (house mouse) ]

    Gene ID: 231946, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Fam221aprovided by MGI
    Official Full Name
    family with sequence similarity 221, member Aprovided by MGI
    Primary source
    MGI:MGI:2442161
    See related
    Ensembl:ENSMUSG00000047115 AllianceGenome:MGI:2442161
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D330028D13Rik
    Summary
    Orthologous to human FAM221A (family with sequence similarity 221 member A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 5.6), limb E14.5 (RPKM 2.9) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    6 B2.3; 6 23.87 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (49343855..49366839)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (49366921..49389905)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_15825 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E1321 Neighboring gene coiled-coil domain containing 126 Neighboring gene STARR-seq mESC enhancer starr_15828 Neighboring gene STARR-positive B cell enhancer ABC_E3654 Neighboring gene STARR-seq mESC enhancer starr_15829 Neighboring gene STARR-seq mESC enhancer starr_15830 Neighboring gene serine threonine kinase 31 Neighboring gene nucleophosmin 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_15831 Neighboring gene STARR-seq mESC enhancer starr_15832 Neighboring gene STARR-seq mESC enhancer starr_15833 Neighboring gene 40S ribosomal protein S6 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    2. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    3. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    4. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article
    5. Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. Carninci P, et al. Genome Res, 2000 Oct. PMID 11042159, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    protein FAM221A
    Names
    uncharacterized protein C7orf46 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001172216.1 → NP_001165687.1  protein FAM221A isoform 2

      See identical proteins and their annotated locations for NP_001165687.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      BC039996, BC055818, BY145860
      Consensus CDS
      CCDS51769.1
      UniProtKB/Swiss-Prot
      Q8C790
      Related
      ENSMUSP00000113242.2, ENSMUST00000121903.2
      Conserved Domains (1) summary
      pfam14753
      Location:20 → 214
      FAM221; Protein FAM221A/B

    2. NM_172727.3 → NP_766315.1  protein FAM221A isoform 1

      See identical proteins and their annotated locations for NP_766315.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK052323, BC039996, BY145860
      Consensus CDS
      CCDS20126.1
      UniProtKB/Swiss-Prot
      Q7TML5, Q8C790
      Related
      ENSMUSP00000050237.9, ENSMUST00000060561.15
      Conserved Domains (1) summary
      pfam14753
      Location:20 → 214
      FAM221; Protein FAM221A/B

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      49343855..49366839
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030255330.1 → XP_030111190.1  protein FAM221A isoform X5

      Conserved Domains (1) summary
      pfam14753
      Location:49 → 243
      FAM221; Protein FAM221A/B

    2. XM_006505938.4 → XP_006506001.1  protein FAM221A isoform X1

      Conserved Domains (1) summary
      pfam14753
      Location:49 → 243
      FAM221; Protein FAM221A/B

    3. XM_036166034.1 → XP_036021927.1  protein FAM221A isoform X2

      Conserved Domains (1) summary
      pfam14753
      Location:49 → 243
      FAM221; Protein FAM221A/B

    4. XM_006505941.4 → XP_006506004.1  protein FAM221A isoform X3

      See identical proteins and their annotated locations for XP_006506004.1

      UniProtKB/Swiss-Prot
      Q7TML5, Q8C790
      Conserved Domains (1) summary
      pfam14753
      Location:20 → 214
      FAM221; Protein FAM221A/B

    5. XM_036166035.1 → XP_036021928.1  protein FAM221A isoform X6

      Conserved Domains (1) summary
      pfam14753
      Location:20 → 214
      FAM221; Protein FAM221A/B

    6. XM_006505940.4 → XP_006506003.1  protein FAM221A isoform X3

      See identical proteins and their annotated locations for XP_006506003.1

      UniProtKB/Swiss-Prot
      Q7TML5, Q8C790
      Conserved Domains (1) summary
      pfam14753
      Location:20 → 214
      FAM221; Protein FAM221A/B

    7. XM_011241294.3 → XP_011239596.1  protein FAM221A isoform X4

      See identical proteins and their annotated locations for XP_011239596.1

      Conserved Domains (1) summary
      pfam14753
      Location:20 → 214
      FAM221; Protein FAM221A/B
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C790.1 GenPept UniProtKB/Swiss-Prot:Q8C790

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