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    Bud31 BUD31 homolog [ Mus musculus (house mouse) ]

    Gene ID: 231889, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Bud31provided by MGI
    Official Full Name
    BUD31 homologprovided by MGI
    Primary source
    MGI:MGI:2141291
    See related
    Ensembl:ENSMUSG00000038722 AllianceGenome:MGI:2141291
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    G10; EDG2; EDG-2
    Summary
    Predicted to enable nuclear receptor binding activity and nuclear receptor coactivator activity. Predicted to be involved in mRNA splicing, via spliceosome and positive regulation of androgen receptor activity. Predicted to act upstream of or within RNA splicing and mRNA processing. Predicted to be located in nucleus. Predicted to be part of U2-type catalytic step 2 spliceosome. Predicted to colocalize with chromatin. Is expressed in genitourinary system. Orthologous to human BUD31 (BUD31 homolog). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 80.7), placenta adult (RPKM 42.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    5 G2; 5 85.05 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (145077186..145084888)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (145140376..145148078)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:145877013-145877196 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:145877310-145877463 Neighboring gene STARR-positive B cell enhancer ABC_E11730 Neighboring gene actin related protein 2/3 complex, subunit 1B Neighboring gene PDGFA associated protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E8091 Neighboring gene pentatricopeptide repeat domain 1 Neighboring gene STARR-positive B cell enhancer ABC_E6397 Neighboring gene cleavage and polyadenylation specific factor 4 Neighboring gene ATP synthase membrane subunit f

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Bud31-mediated alternative splicing is required for spermatogonial stem cell self-renewal and differentiation. Qin J, et al. Cell Death Differ, 2023 Jan. PMID 36114296, Free PMC Article
    2. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579
    3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Bud31-mediated alternative splicing is required for spermatogonial stem cell self-renewal and differentiation.
      Title: Bud31-mediated alternative splicing is required for spermatogonial stem cell self-renewal and differentiation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables nuclear receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear receptor coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of androgen receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of U2-type catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein BUD31 homolog
    Names
    maternal G10 transcript
    protein G10 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008705.2 → NP_001008705.1  protein BUD31 homolog isoform 2

      See identical proteins and their annotated locations for NP_001008705.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks an in-frame exon compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AA051275, BC057025, BP770669
      Consensus CDS
      CCDS19857.1
      UniProtKB/Swiss-Prot
      Q6PGH1
      Related
      ENSMUSP00000125590.2, ENSMUST00000162308.8
      Conserved Domains (1) summary
      pfam01125
      Location:1 → 102
      G10; G10 protein

    2. NM_001310770.1 → NP_001297699.1  protein BUD31 homolog isoform 1

      See identical proteins and their annotated locations for NP_001297699.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AC127411, BP770669, BX520786, CX567360
      Consensus CDS
      CCDS80463.1
      UniProtKB/Swiss-Prot
      E0CX20, Q6PGH1
      Related
      ENSMUSP00000125564.2, ENSMUST00000160075.2
      Conserved Domains (1) summary
      pfam01125
      Location:1 → 143
      G10; G10 protein

    3. NM_001310771.1 → NP_001297700.1  protein BUD31 homolog isoform 1

      See identical proteins and their annotated locations for NP_001297700.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AA051275, BP770669, CJ044770, CJ047068, CX567360
      Consensus CDS
      CCDS80463.1
      UniProtKB/Swiss-Prot
      E0CX20, Q6PGH1
      Related
      ENSMUSP00000125738.2, ENSMUST00000162594.8
      Conserved Domains (1) summary
      pfam01125
      Location:1 → 143
      G10; G10 protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      145077186..145084888
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PGH1.2 GenPept UniProtKB/Swiss-Prot:Q6PGH1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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