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    B3gnt4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 [ Mus musculus (house mouse) ]

    Gene ID: 231727, updated on 5-Mar-2024

    Summary

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    Official Symbol
    B3gnt4provided by MGI
    Official Full Name
    UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4provided by MGI
    Primary source
    MGI:MGI:2680208
    See related
    Ensembl:ENSMUSG00000029431 AllianceGenome:MGI:2680208
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BGnT-4; 1010001G17Rik
    Summary
    Predicted to enable N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity. Predicted to be involved in poly-N-acetyllactosamine biosynthetic process. Predicted to be located in Golgi apparatus and membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi membrane. Is expressed in embryo. Orthologous to human B3GNT4 (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis adult (RPKM 8.3), lung adult (RPKM 3.2) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    5 F; 5 63.02 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (123646519..123649945)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (123508461..123511882)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene interleukin 31 Neighboring gene leucine rich repeat containing 43 Neighboring gene diablo, IAP-binding mitochondrial protein Neighboring gene STARR-positive B cell enhancer ABC_E2175 Neighboring gene microRNA 7647 Neighboring gene VPS33A CORVET/HOPS core subunit Neighboring gene STARR-positive B cell enhancer mm9_chr5:123993667-123993967 Neighboring gene STARR-positive B cell enhancer ABC_E2176

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The trafficking protein Tmed2/p24beta(1) is required for morphogenesis of the mouse embryo and placenta. Jerome-Majewska LA, et al. Dev Biol, 2010 May 1. PMID 20178780, Free PMC Article
    2. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    4. Functional annotation of a full-length mouse cDNA collection. Kawai J, et al. Nature, 2001 Feb 8. PMID 11217851
    5. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, et al. Nature, 2002 Dec 5. PMID 12466851

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hexosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in poly-N-acetyllactosamine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in poly-N-acetyllactosamine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein O-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 4
    Names
    beta-1,3-Gn-T4
    beta3Gn-T4
    NP_001369783.1
    NP_941013.2
    XP_006530376.1
    XP_011246501.1
    XP_011246502.1
    XP_036020986.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001382854.1 → NP_001369783.1  N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 4

      Status: VALIDATED

      Source sequence(s)
      AC157931
      UniProtKB/Swiss-Prot
      E9QPF4, Q1RLK6, Q923H4
      Conserved Domains (1) summary
      cl21608
      Location:106 → 295
      Galactosyl_T; Galactosyltransferase

    2. NM_198611.2 → NP_941013.2  N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 4

      See identical proteins and their annotated locations for NP_941013.2

      Status: VALIDATED

      Source sequence(s)
      AC157931, BC115755
      Consensus CDS
      CCDS19665.1
      UniProtKB/Swiss-Prot
      E9QPF4, Q1RLK6, Q923H4
      Related
      ENSMUSP00000031384.6, ENSMUST00000031384.6
      Conserved Domains (1) summary
      cl21608
      Location:106 → 295
      Galactosyl_T; Galactosyltransferase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      123646519..123649945
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530313.5 → XP_006530376.1  N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 4 isoform X2

      See identical proteins and their annotated locations for XP_006530376.1

      UniProtKB/Swiss-Prot
      E9QPF4, Q1RLK6, Q923H4
      Conserved Domains (1) summary
      cl21608
      Location:106 → 295
      Galactosyl_T; Galactosyltransferase

    2. XM_036165093.1 → XP_036020986.1  N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 4 isoform X2

      UniProtKB/Swiss-Prot
      E9QPF4, Q1RLK6, Q923H4
      Conserved Domains (1) summary
      cl21608
      Location:106 → 295
      Galactosyl_T; Galactosyltransferase

    3. XM_011248200.3 → XP_011246502.1  N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 4 isoform X2

      See identical proteins and their annotated locations for XP_011246502.1

      UniProtKB/Swiss-Prot
      E9QPF4, Q1RLK6, Q923H4
      Conserved Domains (1) summary
      cl21608
      Location:106 → 295
      Galactosyl_T; Galactosyltransferase

    4. XM_011248199.3 → XP_011246501.1  N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 4 isoform X1

      Conserved Domains (1) summary
      cl21608
      Location:166 → 355
      Galactosyl_T; Galactosyltransferase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q1RLK6.2 GenPept UniProtKB/Swiss-Prot:Q1RLK6

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