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    Rad9b RAD9 checkpoint clamp component B [ Mus musculus (house mouse) ]

    Gene ID: 231724, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Rad9bprovided by MGI
    Official Full Name
    RAD9 checkpoint clamp component Bprovided by MGI
    Primary source
    MGI:MGI:2385231
    See related
    Ensembl:ENSMUSG00000038569 AllianceGenome:MGI:2385231
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A630082N15Rik
    Summary
    Predicted to be involved in DNA integrity checkpoint signaling; DNA repair; and cellular response to ionizing radiation. Predicted to be located in nucleus. Predicted to be part of checkpoint clamp complex. Is expressed in embryo and future brain. Orthologous to human RAD9B (RAD9 checkpoint clamp component B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in bladder adult (RPKM 5.4), testis adult (RPKM 5.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    5 F; 5 62.3 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (122461286..122492297, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (122323223..122354270, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene hydrogen voltage-gated channel 1 Neighboring gene tectonic family member 1 Neighboring gene STARR-positive B cell enhancer ABC_E6375 Neighboring gene STARR-positive B cell enhancer ABC_E10345 Neighboring gene RIKEN cDNA 1700112N08 gene Neighboring gene STARR-seq mESC enhancer starr_14278 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:122738438-122738621 Neighboring gene PTC7 protein phosphatase homolog Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:122760748-122760949 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:122761679-122761976 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:122767369-122767570 Neighboring gene STARR-positive B cell enhancer ABC_E2761 Neighboring gene STARR-seq mESC enhancer starr_14283 Neighboring gene VPS29 retromer complex component Neighboring gene family with sequence similarity 216, member A Neighboring gene predicted gene, 32853 Neighboring gene GPN-loop GTPase 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mouse Rad9b is essential for embryonic development and promotes resistance to DNA damage. Leloup C, et al. Dev Dyn, 2010 Nov. PMID 20842695, Free PMC Article
    2. Rad9 protein contributes to prostate tumor progression by promoting cell migration and anoikis resistance. Broustas CG, et al. J Biol Chem, 2012 Nov 30. PMID 23066031, Free PMC Article
    3. Rad9 plays an important role in DNA mismatch repair through physical interaction with MLH1. He W, et al. Nucleic Acids Res, 2008 Nov. PMID 18842633, Free PMC Article
    4. Identification and characterization of RAD9B, a paralog of the RAD9 checkpoint gene. Dufault VM, et al. Genomics, 2003 Dec. PMID 14611806
    5. Expression of mammalian paralogues of HRAD9 and Mrad9 checkpoint control genes in normal and cancerous testicular tissue. Hopkins KM, et al. Cancer Res, 2003 Sep 1. PMID 14500360

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC28469

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in DNA damage checkpoint signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA replication checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to ionizing radiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic intra-S DNA damage checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of checkpoint clamp complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cell cycle checkpoint control protein RAD9B
    Names
    DNA repair exonuclease rad9 homolog B
    RAD9 homolog B
    cell cycle checkpoint control protein RAD9B homolog
    mRAD9B
    NP_001369782.1
    NP_659161.2
    XP_006530368.1
    XP_006530369.1
    XP_006530371.1
    XP_006530373.1
    XP_017176358.1
    XP_036020985.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001382853.1 → NP_001369782.1  cell cycle checkpoint control protein RAD9B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC093473, AC113285
      UniProtKB/TrEMBL
      D3Z3W7
      Related
      ENSMUSP00000113868.3, ENSMUST00000117263.8
      Conserved Domains (1) summary
      pfam04139
      Location:14 → 271
      Rad9

    2. NM_144912.4 → NP_659161.2  cell cycle checkpoint control protein RAD9B isoform 1

      See identical proteins and their annotated locations for NP_659161.2

      Status: VALIDATED

      Source sequence(s)
      AC093473, AC113285
      Consensus CDS
      CCDS19646.1
      UniProtKB/Swiss-Prot
      Q6WBX7
      UniProtKB/TrEMBL
      D3Z3W7, Q8VC54
      Related
      ENSMUSP00000036177.7, ENSMUST00000049009.7
      Conserved Domains (2) summary
      cd00577
      Location:10 → 273
      PCNA; Proliferating Cell Nuclear Antigen (PCNA) domain found in eukaryotes and archaea. These polymerase processivity factors play a role in DNA replication and repair. PCNA encircles duplex DNA in its central cavity, providing a DNA-bound platform for the ...
      pfam04139
      Location:14 → 271
      Rad9; Rad9

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      122461286..122492297 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530310.4 → XP_006530373.1  cell cycle checkpoint control protein RAD9B isoform X4

      Conserved Domains (1) summary
      pfam04139
      Location:1 → 118
      Rad9

    2. XM_017320869.3 → XP_017176358.1  cell cycle checkpoint control protein RAD9B isoform X3

      Conserved Domains (1) summary
      pfam04139
      Location:21 → 203
      Rad9

    3. XM_006530306.5 → XP_006530369.1  cell cycle checkpoint control protein RAD9B isoform X1

      See identical proteins and their annotated locations for XP_006530369.1

      UniProtKB/TrEMBL
      D3Z3W7
      Conserved Domains (1) summary
      pfam04139
      Location:21 → 278
      Rad9

    4. XM_006530305.5 → XP_006530368.1  cell cycle checkpoint control protein RAD9B isoform X1

      See identical proteins and their annotated locations for XP_006530368.1

      UniProtKB/TrEMBL
      D3Z3W7
      Conserved Domains (1) summary
      pfam04139
      Location:21 → 278
      Rad9

    5. XM_006530308.5 → XP_006530371.1  cell cycle checkpoint control protein RAD9B isoform X2

      UniProtKB/TrEMBL
      D3Z3W7
      Conserved Domains (1) summary
      pfam04139
      Location:21 → 228
      Rad9

    6. XM_036165092.1 → XP_036020985.1  cell cycle checkpoint control protein RAD9B isoform X3

      Conserved Domains (1) summary
      pfam04139
      Location:21 → 203
      Rad9

    RNA

    1. XR_001784685.3 RNA Sequence

    2. XR_004942507.1 RNA Sequence

    3. XR_001784684.3 RNA Sequence

    4. XR_387562.5 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6WBX7.1 GenPept UniProtKB/Swiss-Prot:Q6WBX7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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