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    Gcn1 GCN1 activator of EIF2AK4 [ Mus musculus (house mouse) ]

    Gene ID: 231659, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Gcn1provided by MGI
    Official Full Name
    GCN1 activator of EIF2AK4provided by MGI
    Primary source
    MGI:MGI:2444248
    See related
    Ensembl:ENSMUSG00000041638 AllianceGenome:MGI:2444248
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GCN1L; Gcn1l1; mKIAA0219; 4932409G22; G431004K08Rik
    Summary
    Predicted to enable protein kinase binding activity; protein kinase regulator activity; and ribosome binding activity. Involved in cellular response to leucine starvation and positive regulation of transcription from RNA polymerase II promoter in response to stress. Part of polysome. Is expressed in several structures, including gut; heart; hemolymphoid system gland; liver; and lung. Orthologous to human GCN1 (GCN1 activator of EIF2AK4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary adult (RPKM 25.3), thymus adult (RPKM 23.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    5 F; 5 56.1 cM
    Exon count:
    58
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (115703177..115760713)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (115565117..115622654)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene paxillin Neighboring gene STARR-seq mESC enhancer starr_14131 Neighboring gene predicted gene 13840 Neighboring gene STARR-seq mESC enhancer starr_14132 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:115984948-115985057 Neighboring gene STARR-positive B cell enhancer ABC_E1687 Neighboring gene STARR-positive B cell enhancer ABC_E671 Neighboring gene ribosomal protein lateral stalk subunit P0 Neighboring gene microRNA 7029 Neighboring gene RIKEN cDNA 1110006O24 gene Neighboring gene RAB35, member RAS oncogene family Neighboring gene microRNA 7030

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Inducible Systemic Gcn1 Deletion in Mice Leads to Transient Body Weight Loss upon Tamoxifen Treatment Associated with Decrease of Fat and Liver Glycogen Storage. Liu J, et al. Int J Mol Sci, 2022 Mar 16. PMID 35328622, Free PMC Article
    2. Ribosome binding protein GCN1 regulates the cell cycle and cell proliferation and is essential for the embryonic development of mice. Yamazaki H, et al. PLoS Genet, 2020 Apr. PMID 32324833, Free PMC Article
    3. IMPACT is a developmentally regulated protein in neurons that opposes the eukaryotic initiation factor 2α kinase GCN2 in the modulation of neurite outgrowth. Roffé M, et al. J Biol Chem, 2013 Apr 12. PMID 23447528, Free PMC Article
    4. Evolutionarily conserved IMPACT impairs various stress responses that require GCN1 for activating the eIF2 kinase GCN2. Cambiaghi TD, et al. Biochem Biophys Res Commun, 2014 Jan 10. PMID 24333428
    5. Evidence that Yih1 resides in a complex with ribosomes. Waller T, et al. FEBS J, 2012 May. PMID 22404850

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of GCN1 causes severe growth retardation and embryonic lethality. GCN1 regulates the eIF2alpha-mediated stress response, cell cycle and cell proliferation.
      Title: Ribosome binding protein GCN1 regulates the cell cycle and cell proliferation and is essential for the embryonic development of mice.
    2. This study extends our understanding of the roles played by GCN1 in GCN2 activation induced by a variety of stress arrangements and suggests that IMPACT and YIH1 use similar mechanisms for regulating this eIF2alpha kinase.
      Title: Evolutionarily conserved IMPACT impairs various stress responses that require GCN1 for activating the eIF2 kinase GCN2.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables stalled ribosome sensor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in GCN2-mediated signaling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to amino acid starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to amino acid starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rescue of stalled ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    is_active_in cytosolic ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    stalled ribosome sensor GCN1
    Names
    GCN1 eIF-2-alpha kinase activator homolog
    GCN1 general control of amino-acid synthesis 1-like 1
    GCN1-like protein 1
    eIF-2-alpha kinase activator GCN1
    general control of amino-acid synthesis 1-like protein 1
    translational activator GCN1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172719.2 → NP_766307.2  stalled ribosome sensor GCN1

      Status: VALIDATED

      Source sequence(s)
      AK077013, AK089324, AK147257, BY582410, CD350892, CJ104712
      Consensus CDS
      CCDS19595.1
      UniProtKB/Swiss-Prot
      B2RWW6, E9PVA8
      UniProtKB/TrEMBL
      Q3UHQ5
      Related
      ENSMUSP00000069432.8, ENSMUST00000064454.12
      Conserved Domains (4) summary
      cd00020
      Location:1498 → 1601
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam12074
      Location:355 → 705
      DUF3554; Domain of unknown function (DUF3554)
      pfam13646
      Location:1616 → 1721
      HEAT_2; HEAT repeats
      sd00044
      Location:1461 → 1485
      HEAT; HEAT repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      115703177..115760713
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_001784681.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E9PVA8.1 GenPept UniProtKB/Swiss-Prot:E9PVA8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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