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    Myo1h myosin 1H [ Mus musculus (house mouse) ]

    Gene ID: 231646, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Myo1hprovided by MGI
    Official Full Name
    myosin 1Hprovided by MGI
    Primary source
    MGI:MGI:1914674
    See related
    Ensembl:ENSMUSG00000066952 AllianceGenome:MGI:1914674
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4631401O15Rik
    Summary
    Predicted to enable actin filament binding activity and microfilament motor activity. Predicted to be involved in actin filament organization and vesicle transport along actin filament. Predicted to be part of myosin complex. Predicted to be active in several cellular components, including actin cytoskeleton; microvillus; and vesicle. Is expressed in several structures, including alimentary system; gonad; nervous system; neural retina; and respiratory system. Orthologous to human MYO1H (myosin IH). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in lung adult (RPKM 21.5), stomach adult (RPKM 10.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    5 F; 5 55.99 cM
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (114427314..114502637)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (114289253..114364576)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene acetyl-Coenzyme A carboxylase beta Neighboring gene STARR-seq mESC enhancer starr_14069 Neighboring gene STARR-seq mESC enhancer starr_14070 Neighboring gene forkhead box N4 Neighboring gene VISTA enhancer mm1522 Neighboring gene STARR-positive B cell enhancer mm9_chr5:114762243-114762544 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:114765155-114765411 Neighboring gene potassium channel tetramerisation domain containing 10 Neighboring gene ubiquitin protein ligase E3B Neighboring gene microRNA 7027 Neighboring gene STARR-positive B cell enhancer ABC_E278 Neighboring gene methylmalonic aciduria (cobalamin deficiency) cblB type homolog (human)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Myosin-I isozymes in neonatal rodent auditory and vestibular epithelia. Dumont RA, et al. J Assoc Res Otolaryngol, 2002 Dec. PMID 12486594, Free PMC Article
    2. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
    3. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cytoskeletal motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microfilament motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microvillus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    unconventional myosin-Ih
    Names
    myosin-Ih

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164573.2 → NP_001158045.1  unconventional myosin-Ih isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC122282, AC127255
      Consensus CDS
      CCDS51622.1
      UniProtKB/TrEMBL
      A0A0J9YUC4, E9PWM9
      Related
      ENSMUSP00000144110.2, ENSMUST00000202006.4
      Conserved Domains (3) summary
      smart00242
      Location:8 → 689
      MYSc; Myosin. Large ATPases
      cd01378
      Location:26 → 678
      MYSc_Myo1; class I myosin, motor domain
      pfam06017
      Location:834 → 1001
      Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

    2. NM_001368675.1 → NP_001355604.1  unconventional myosin-Ih isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC127255
      Consensus CDS
      CCDS89974.1
      UniProtKB/TrEMBL
      B7ZMY1, B7ZMY2
      Related
      ENSMUSP00000144682.2, ENSMUST00000196676.5
      Conserved Domains (1) summary
      pfam06017
      Location:25 → 206
      Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

    3. NM_001368676.1 → NP_001355605.1  unconventional myosin-Ih isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC127255
      Consensus CDS
      CCDS89974.1
      UniProtKB/TrEMBL
      B7ZMY1, B7ZMY2
      Related
      ENSMUSP00000144492.2, ENSMUST00000199567.5
      Conserved Domains (1) summary
      pfam06017
      Location:25 → 206
      Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      114427314..114502637
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165090.1 → XP_036020983.1  unconventional myosin-Ih isoform X1

      UniProtKB/TrEMBL
      B7ZMY1, B7ZMY2
      Conserved Domains (1) summary
      pfam06017
      Location:25 → 206
      Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_146163.2: Suppressed sequence

      Description
      NM_146163.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D6A1.2 GenPept UniProtKB/Swiss-Prot:Q9D6A1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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