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    Ficd FIC domain containing [ Mus musculus (house mouse) ]

    Gene ID: 231630, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Ficdprovided by MGI
    Official Full Name
    FIC domain containingprovided by MGI
    Primary source
    MGI:MGI:1098550
    See related
    Ensembl:ENSMUSG00000053334 AllianceGenome:MGI:1098550
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hype; D5Ertd40e
    Summary
    Predicted to enable several functions, including ATP binding activity; Hsp70 protein binding activity; and chaperone binding activity. Predicted to be involved in protein adenylylation; regulation of IRE1-mediated unfolded protein response; and response to endoplasmic reticulum stress. Predicted to act upstream of or within response to unfolded protein. Predicted to be integral component of endoplasmic reticulum membrane. Is expressed in central nervous system; genitourinary system; gut gland; and stomach. Orthologous to human FICD (FIC domain protein adenylyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in genital fat pad adult (RPKM 5.9), adrenal adult (RPKM 5.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    5 F; 5 55.55 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (113873821..113878670)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (113735758..113740607)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene chemerin chemokine-like receptor 1 Neighboring gene predicted gene, 52823 Neighboring gene RIKEN cDNA 1700069L16 gene Neighboring gene predicted gene, 46919 Neighboring gene STARR-positive B cell enhancer ABC_E2171 Neighboring gene squamous cell carcinoma antigen recognized by T cells 3 Neighboring gene STARR-seq mESC enhancer starr_14052 Neighboring gene STARR-positive B cell enhancer ABC_E9260 Neighboring gene 40S ribosomal protein S28 pseudogene Neighboring gene iron-sulfur cluster assembly enzyme

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Deletion of mFICD AMPylase alters cytokine secretion and affects visual short-term learning in vivo. McCaul N, et al. J Biol Chem, 2021 Sep. PMID 34419450, Free PMC Article
    2. Fic-mediated AMPylation tempers the unfolded protein response during physiological stress. Casey AK, et al. Proc Natl Acad Sci U S A, 2022 Aug 9. PMID 35914137, Free PMC Article
    3. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579
    4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Fic-mediated AMPylation tempers the unfolded protein response during physiological stress.
      Title: Fic-mediated AMPylation tempers the unfolded protein response during physiological stress.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (3)  1 citation

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC117722

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables AMPylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables Hsp70 protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-folding chaperone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein adenylylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of IRE1-mediated unfolded protein response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to unfolded protein IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein adenylyltransferase FICD
    Names
    AMPylator FICD
    FIC domain-containing protein
    adenosine monophosphate-protein transferase FICD
    de-AMPylase FICD
    huntingtin interacting protein E
    huntingtin interactor protein E
    NP_001010825.2
    XP_006530348.1
    XP_006530349.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001010825.3 → NP_001010825.2  protein adenylyltransferase FICD

      See identical proteins and their annotated locations for NP_001010825.2

      Status: VALIDATED

      Source sequence(s)
      BC106090, BP765693, BY271260
      Consensus CDS
      CCDS51620.1
      UniProtKB/Swiss-Prot
      A4QPF9, Q8BIC9, Q8BIX9, Q8BJ12
      Related
      ENSMUSP00000071719.5, ENSMUST00000065698.7
      Conserved Domains (3) summary
      COG3177
      Location:227 → 411
      COG3177; Fic family protein [Transcription]
      TIGR02917
      Location:89 → 180
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:106 → 134
      TPR; TPR repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      113873821..113878670
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530285.5 → XP_006530348.1  protein adenylyltransferase FICD isoform X2

      See identical proteins and their annotated locations for XP_006530348.1

      UniProtKB/Swiss-Prot
      A4QPF9, Q8BIC9, Q8BIX9, Q8BJ12
      Conserved Domains (3) summary
      COG3177
      Location:227 → 411
      COG3177; Fic family protein [Transcription]
      TIGR02917
      Location:89 → 180
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:106 → 134
      TPR; TPR repeat [structural motif]

    2. XM_006530286.4 → XP_006530349.1  protein adenylyltransferase FICD isoform X1

      Conserved Domains (3) summary
      COG3177
      Location:226 → 410
      COG3177; Fic family protein [Transcription]
      TIGR02917
      Location:97 → 179
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:105 → 133
      TPR; TPR repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BIX9.1 GenPept UniProtKB/Swiss-Prot:Q8BIX9

    Gene LinkOut

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