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    Plac8 placenta-specific 8 [ Mus musculus (house mouse) ]

    Gene ID: 231507, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Plac8provided by MGI
    Official Full Name
    placenta-specific 8provided by MGI
    Primary source
    MGI:MGI:2445289
    See related
    Ensembl:ENSMUSG00000029322 AllianceGenome:MGI:2445289
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C15; D5Wsu111e
    Summary
    Enables chromatin binding activity. Involved in positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including brown fat cell differentiation; defense response to bacterium; and response to cold. Predicted to be located in nucleus. Is expressed in several structures, including extraembryonic component; gut; liver lobe; oculomotor nerve; and prostate gland lobe. Orthologous to human PLAC8 (placenta associated 8). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in duodenum adult (RPKM 141.6), large intestine adult (RPKM 140.7) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    5 E4; 5 48.49 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (100699455..100720119, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (100551589..100572253, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2163 Neighboring gene predicted gene, 19620 Neighboring gene COP9 signalosome subunit 4 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:100998499-100998608 Neighboring gene STARR-positive B cell enhancer ABC_E11295 Neighboring gene STARR-positive B cell enhancer ABC_E11296 Neighboring gene STARR-positive B cell enhancer mm9_chr5:101027025-101027325 Neighboring gene STARR-positive B cell enhancer ABC_E9256 Neighboring gene STARR-positive B cell enhancer ABC_E8823 Neighboring gene coenzyme Q2 4-hydroxybenzoate polyprenyltransferase Neighboring gene STARR-seq mESC enhancer starr_13729 Neighboring gene heparanase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. PLAC8 promotes EV71 infected inflammatory lesion by disturbing Th-cell-related cytokines release in neonatal mouse. Yang X, et al. Virology, 2021 Dec. PMID 34653773
    2. CRISPR/Cas9-mediated generation of a Plac8 knockout mouse model. Lee H, et al. Lab Anim Res, 2018 Dec. PMID 30671116, Free PMC Article
    3. Plac8 is required for white adipocyte differentiation in vitro and cell number control in vivo. Jimenez-Preitner M, et al. PLoS One, 2012. PMID 23155406, Free PMC Article
    4. Onzin, a c-Myc-repressed target, promotes survival and transformation by modulating the Akt-Mdm2-p53 pathway. Rogulski K, et al. Oncogene, 2005 Nov 17. PMID 16170375
    5. Plac8-mediated autophagy regulates nasopharyngeal carcinoma cell function via AKT/mTOR pathway. Huang ML, et al. J Cell Mol Med, 2020 Jul. PMID 32468683, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PLAC8 promotes EV71 infected inflammatory lesion by disturbing Th-cell-related cytokines release in neonatal mouse.
      Title: PLAC8 promotes EV71 infected inflammatory lesion by disturbing Th-cell-related cytokines release in neonatal mouse.
    2. Plac8-mediated autophagy regulates nasopharyngeal carcinoma cell function via AKT/mTOR pathway.
      Title: Plac8-mediated autophagy regulates nasopharyngeal carcinoma cell function via AKT/mTOR pathway.
    3. Results establish PLAC8 as a central mediator of tumor progression in PDAC.
      Title: PLAC8 Localizes to the Inner Plasma Membrane of Pancreatic Cancer Cells and Regulates Cell Growth and Disease Progression through Critical Cell-Cycle Regulatory Pathways.
    4. Plac8 provides a mechanistic link between primary oncogenic mutations and the induction of autophagy, a central mechanism of metabolic reprogramming, during PDA progression.
      Title: Plac8 links oncogenic mutations to regulation of autophagy and is critical to pancreatic cancer progression.
    5. Plac8 is an upstream regulator of C/EBPbeta required for adipogenesis in vitro. In vivo, Plac8 is dispensable for the differentiation of white adipocytes with preserved fat storage capacity but is required for normal fat cell count regulation
      Title: Plac8 is required for white adipocyte differentiation in vitro and cell number control in vivo.
    6. Data indicate that dampened contact hypersensitivity (CHS) responses correlated with a significant reduction in pro-inflammatory IL-6 at the challenge site in ONZIN-deficient animals.
      Title: ONZIN deficiency attenuates contact hypersensitivity responses in mice.
    7. These results demonstrate that there are two independent and redundant T cell mechanisms for clearing C. muridarum genital tract infections: one dependent on iNOS, and the other dependent on Plac8.
      Title: Plac8-dependent and inducible NO synthase-dependent mechanisms clear Chlamydia muridarum infections from the genital tract.
    8. These findings demonstrate a functional interdependence between onzin and PLSCR1.
      Title: The negative c-Myc target onzin affects proliferation and apoptosis via its obligate interaction with phospholipid scramblase 1.
    9. results identify onzin as a novel regulator of several p53-dependent aspects of the c-Myc phenotype via its dramatic effect on Mdm2
      Title: Onzin, a c-Myc-repressed target, promotes survival and transformation by modulating the Akt-Mdm2-p53 pathway.
    10. ONZIN as a novel class of intracellular protein required for optimal function of the neutrophils after uptake of bacteria.
      Title: Impaired host defense in mice lacking ONZIN.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within brown fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of cold-induced thermogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within response to cold IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus IC
    Inferred by Curator
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    placenta-specific gene 8 protein
    Names
    onzin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001370754.1 → NP_001357683.1  placenta-specific gene 8 protein

      Status: VALIDATED

      Source sequence(s)
      AC109196
      Consensus CDS
      CCDS19464.1
      UniProtKB/Swiss-Prot
      Q9JI48
      Related
      ENSMUSP00000108531.2, ENSMUST00000112910.2
      Conserved Domains (1) summary
      TIGR01571
      Location:21 → 105
      A_thal_Cys_rich; uncharacterized Cys-rich domain

    2. NM_139198.3 → NP_631937.1  placenta-specific gene 8 protein

      See identical proteins and their annotated locations for NP_631937.1

      Status: VALIDATED

      Source sequence(s)
      AC109196
      Consensus CDS
      CCDS19464.1
      UniProtKB/Swiss-Prot
      Q9JI48
      Related
      ENSMUSP00000031264.6, ENSMUST00000031264.12
      Conserved Domains (1) summary
      TIGR01571
      Location:21 → 105
      A_thal_Cys_rich; uncharacterized Cys-rich domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      100699455..100720119 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030254403.1 → XP_030110263.1  placenta-specific gene 8 protein isoform X2

    2. XM_017320850.2 → XP_017176339.1  placenta-specific gene 8 protein isoform X1

    3. XM_030254402.2 → XP_030110262.1  placenta-specific gene 8 protein isoform X1

    4. XM_017320849.3 → XP_017176338.1  placenta-specific gene 8 protein isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JI48.1 GenPept UniProtKB/Swiss-Prot:Q9JI48

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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