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    Tmem150c transmembrane protein 150C [ Mus musculus (house mouse) ]

    Gene ID: 231503, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Tmem150cprovided by MGI
    Official Full Name
    transmembrane protein 150Cprovided by MGI
    Primary source
    MGI:MGI:3041258
    See related
    Ensembl:ENSMUSG00000050640 AllianceGenome:MGI:3041258
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables mechanosensitive ion channel activity. Involved in cellular response to mechanical stimulus and proprioception. Located in plasma membrane. Is expressed in central nervous system; dorsal root ganglion; and rib. Orthologous to human TMEM150C (transmembrane protein 150C). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in genital fat pad adult (RPKM 33.9), CNS E18 (RPKM 5.4) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tmem150c in Genome Data Viewer
    Location:
    5 E4; 5 48.46 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (100225731..100313463, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (100077872..100165607, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930524J08 gene Neighboring gene STARR-seq mESC enhancer starr_13719 Neighboring gene heterogeneous nuclear ribonucleoprotein D Neighboring gene STARR-positive B cell enhancer ABC_E2161 Neighboring gene STARR-seq mESC enhancer starr_13720 Neighboring gene heterogeneous nuclear ribonucleoprotein D-like Neighboring gene enolase-phosphatase 1 Neighboring gene STARR-positive B cell enhancer ABC_E8822 Neighboring gene transmembrane protein 150C, opposite strand Neighboring gene predicted gene, 36167 Neighboring gene RIKEN cDNA 2310034O05 gene Neighboring gene predicted gene, 36304 Neighboring gene stearoyl-CoA desaturase 5 pseudogene Neighboring gene STARR-seq mESC enhancer starr_13721 Neighboring gene predicted gene, 42129

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Lack of evidence for participation of TMEM150C in sensory mechanotransduction. Ojeda-Alonso J, et al. J Gen Physiol, 2022 Dec 5. PMID 36256908, Free PMC Article
    2. Tentonin 3/TMEM150C regulates glucose-stimulated insulin secretion in pancreatic β-cells. Wee J, et al. Cell Rep, 2021 Nov 30. PMID 34852221
    3. Tentonin 3/TMEM150C senses blood pressure changes in the aortic arch. Lu HJ, et al. J Clin Invest, 2020 Jul 1. PMID 32484458, Free PMC Article
    4. Tentonin 3/TMEM150c Confers Distinct Mechanosensitive Currents in Dorsal-Root Ganglion Neurons with Proprioceptive Function. Hong GS, et al. Neuron, 2016 Jul 6. PMID 27321926
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Lack of evidence for participation of TMEM150C in sensory mechanotransduction.
      Title: Lack of evidence for participation of TMEM150C in sensory mechanotransduction.
    2. Tentonin 3/TMEM150C regulates glucose-stimulated insulin secretion in pancreatic beta-cells.
      Title: Tentonin 3/TMEM150C regulates glucose-stimulated insulin secretion in pancreatic β-cells.
    3. Tentonin 3/TMEM150C senses blood pressure changes in the aortic arch.
      Title: Tentonin 3/TMEM150C senses blood pressure changes in the aortic arch.
    4. TTN3 appears to be a component of a mechanosensitive channel with a slow inactivation rate and contributes to motor coordination. Identification of this gene advances our understanding of the various types of mechanosensations, including proprioception
      Title: Tentonin 3/TMEM150c Confers Distinct Mechanosensitive Currents in Dorsal-Root Ganglion Neurons with Proprioceptive Function.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (3)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables mechanosensitive monoatomic ion channel activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to mechanical stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proprioception IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 150C
    Names
    tentonin 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001382850.1 → NP_001369779.1  transmembrane protein 150C isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC124480, AC125378
      UniProtKB/Swiss-Prot
      D3YVG3, Q3TL78, Q8C8S3, Q8K117
      Conserved Domains (1) summary
      pfam10277
      Location:8 → 217
      Frag1; Frag1/DRAM/Sfk1 family

    2. NM_001382851.1 → NP_001369780.1  transmembrane protein 150C isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC124480, AC125378
      UniProtKB/Swiss-Prot
      D3YVG3, Q3TL78, Q8C8S3, Q8K117
      Conserved Domains (1) summary
      pfam10277
      Location:8 → 217
      Frag1; Frag1/DRAM/Sfk1 family

    3. NM_001424763.1 → NP_001411692.1  transmembrane protein 150C isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC124480, AC125378

    4. NM_001424764.1 → NP_001411693.1  transmembrane protein 150C isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC124480, AC125378

    5. NM_001424765.1 → NP_001411694.1  transmembrane protein 150C isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC124480, AC125378

    6. NM_001424766.1 → NP_001411695.1  transmembrane protein 150C isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC124480, AC125378

    7. NM_001424767.1 → NP_001411696.1  transmembrane protein 150C isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC124480, AC125378

    8. NM_001424768.1 → NP_001411697.1  transmembrane protein 150C isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC124480, AC125378

    9. NM_001424769.1 → NP_001411698.1  transmembrane protein 150C isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC124480, AC125378

    10. NM_001424770.1 → NP_001411699.1  transmembrane protein 150C isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC124480, AC125378

    11. NM_182841.2 → NP_878261.1  transmembrane protein 150C isoform 1

      See identical proteins and their annotated locations for NP_878261.1

      Status: VALIDATED

      Source sequence(s)
      AC124480, AC125378
      Consensus CDS
      CCDS19461.1
      UniProtKB/Swiss-Prot
      D3YVG3, Q3TL78, Q8C8S3, Q8K117
      Related
      ENSMUSP00000057116.9, ENSMUST00000063192.15
      Conserved Domains (1) summary
      pfam10277
      Location:8 → 217
      Frag1; Frag1/DRAM/Sfk1 family

    RNA

    1. NR_188912.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC124480, AC125378

    2. NR_188913.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC124480, AC125378

    3. NR_188914.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC124480, AC125378

    4. NR_188915.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC124480, AC125378

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      100225731..100313463 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534877.3 → XP_006534940.1  transmembrane protein 150C isoform X1

      See identical proteins and their annotated locations for XP_006534940.1

      UniProtKB/Swiss-Prot
      D3YVG3, Q3TL78, Q8C8S3, Q8K117
      Conserved Domains (1) summary
      pfam10277
      Location:8 → 217
      Frag1; Frag1/DRAM/Sfk1 family

    2. XM_036165069.1 → XP_036020962.1  transmembrane protein 150C isoform X1

      UniProtKB/Swiss-Prot
      D3YVG3, Q3TL78, Q8C8S3, Q8K117
      Conserved Domains (1) summary
      pfam10277
      Location:8 → 217
      Frag1; Frag1/DRAM/Sfk1 family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C8S3.1 GenPept UniProtKB/Swiss-Prot:Q8C8S3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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