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    Atp10d ATPase, class V, type 10D [ Mus musculus (house mouse) ]

    Gene ID: 231287, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Atp10dprovided by MGI
    Official Full Name
    ATPase, class V, type 10Dprovided by MGI
    Primary source
    MGI:MGI:2450125
    See related
    Ensembl:ENSMUSG00000046808 AllianceGenome:MGI:2450125
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ATPVD; D5Buc24e; 9830145H18Rik
    Summary
    Predicted to enable ATPase-coupled intramembrane lipid transporter activity. Predicted to be involved in phospholipid translocation. Predicted to be active in plasma membrane. Orthologous to human ATP10D (ATPase phospholipid transporting 10D (putative)). [provided by Alliance of Genome Resources, Apr 2022]
    Annotation information
    Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
    Expression
    Ubiquitous expression in spleen adult (RPKM 4.4), subcutaneous fat pad adult (RPKM 3.5) and 27 other tissues See more
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    Genomic context

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    Location:
    5 C3.2; 5 38.44 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (72360672..72456114)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (72203329..72298771)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene gamma-aminobutyric acid type A receptor subunit beta 1 Neighboring gene 60S ribosomal protein L5 pseudogene Neighboring gene STARR-seq mESC enhancer starr_13358 Neighboring gene STARR-positive B cell enhancer mm9_chr5:72551776-72552076 Neighboring gene STARR-positive B cell enhancer mm9_chr5:72559343-72559644 Neighboring gene STARR-positive B cell enhancer ABC_E670 Neighboring gene STARR-seq mESC enhancer starr_13361 Neighboring gene STARR-seq mESC enhancer starr_13362 Neighboring gene STARR-seq mESC enhancer starr_13363 Neighboring gene COMM domain containing 8 Neighboring gene STARR-positive B cell enhancer ABC_E10323 Neighboring gene STARR-positive B cell enhancer ABC_E4761 Neighboring gene predicted gene, 25768 Neighboring gene corin, serine peptidase Neighboring gene STARR-seq mESC enhancer starr_13364 Neighboring gene synaptonemal complex central element protein 2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Lipidomic and metabolic changes in the P4-type ATPase ATP10D deficient C57BL/6J wild type mice upon rescue of ATP10D function. Sigruener A, et al. PLoS One, 2017. PMID 28542499, Free PMC Article
    2. Characterization of a putative type IV aminophospholipid transporter P-type ATPase. Flamant S, et al. Mamm Genome, 2003 Jan. PMID 12532265
    3. Transcriptomic analysis and novel insights into lens fibre cell differentiation regulated by Gata3. Martynova E, et al. Open Biol, 2019 Dec. PMID 31847788, Free PMC Article
    4. A sequence-ready BAC contig of the GABAA receptor gene cluster Gabrg1-Gabra2-Gabrb1 on mouse chromosome 5. Lengeling A, et al. Genome Res, 1999 Aug. PMID 10447508, Free PMC Article
    5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Spontaneous (2)  1 citation
    • Gene trapped (1) 
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Clone Names

    • MGC37731

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables ATPase-coupled intramembrane lipid transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATPase-coupled intramembrane lipid transporter activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables glycosylceramide flippase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables magnesium ion binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in monoatomic cation transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in phospholipid translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of phospholipid-translocating ATPase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    phospholipid-transporting ATPase VD
    Names
    P4-ATPase flippase complex alpha subunit ATP10D
    probable phospholipid-transporting ATPase VD
    putative type IV aminophospholipid transporting ATPase

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153389.3 → NP_700438.3  phospholipid-transporting ATPase VD

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1, coding) represents the protein-coding transcript.
      Source sequence(s)
      AJ441079
      UniProtKB/Swiss-Prot
      Q8K2X1
      Conserved Domains (6) summary
      TIGR01652
      Location:124 → 1377
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
      pfam00122
      Location:181 → 406
      E1-E2_ATPase; E1-E2 ATPase
      pfam13246
      Location:779 → 859
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16209
      Location:124 → 175
      PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
      pfam16212
      Location:1132 → 1377
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
      cl21460
      Location:1101 → 1132
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    RNA

    1. NR_003966.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1, non-coding) represents the transcript expressed in the C57BL/6J mouse strain.
      Source sequence(s)
      AC084780, AC122915, AC129608
      Related
      ENSMUST00000126664.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      72360672..72456114
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K2X1.2 GenPept UniProtKB/Swiss-Prot:Q8K2X1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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