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    Kmt2c lysine (K)-specific methyltransferase 2C [ Mus musculus (house mouse) ]

    Gene ID: 231051, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Kmt2cprovided by MGI
    Official Full Name
    lysine (K)-specific methyltransferase 2Cprovided by MGI
    Primary source
    MGI:MGI:2444959
    See related
    Ensembl:ENSMUSG00000038056 AllianceGenome:MGI:2444959
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HALR; Mll3; E330008K23Rik
    Summary
    Predicted to enable histone binding activity; histone methyltransferase activity (H3-K4 specific); and transcription coactivator activity. Involved in histone methylation. Acts upstream of or within several processes, including eyelid development in camera-type eye; positive regulation of fibroblast proliferation; and single fertilization. Predicted to be located in nucleus. Predicted to be part of MLL3/4 complex. Is expressed in several structures, including eye; genitourinary system; limb; nervous system; and neural ectoderm. Human ortholog(s) of this gene implicated in Klatskin's tumor; Kleefstra syndrome 2; esophagus squamous cell carcinoma; and squamous cell carcinoma. Orthologous to human KMT2C (lysine methyltransferase 2C). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thymus adult (RPKM 7.3), whole brain E14.5 (RPKM 6.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    5 B1; 5 12.35 cM
    Exon count:
    63
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (25476793..25703853, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (25271795..25498855, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 5 Neighboring gene STARR-seq mESC enhancer starr_12661 Neighboring gene polypeptide N-acetylgalactosaminyltransferase 11 Neighboring gene heat shock protein 1 (chaperonin 10), pseudogene 3 Neighboring gene sperm associated antigen 7 pseudogene Neighboring gene RIKEN cDNA 4831440E17 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:25015100-25015283 Neighboring gene predicted gene, 22656

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Loss of Kmt2c in vivo leads to EMT, mitochondrial dysfunction and improved response to lapatinib in breast cancer. Simigdala N, et al. Cell Mol Life Sci, 2023 Mar 18. PMID 36933062, Free PMC Article
    2. Circadian clock function does not require the histone methyltransferase MLL3. Baxter M, et al. FASEB J, 2022 Jul. PMID 35704036, Free PMC Article
    3. Loss of Mll3 Catalytic Function Promotes Aberrant Myelopoiesis. Arcipowski KM, et al. PLoS One, 2016. PMID 27610619, Free PMC Article
    4. Histone methyltransferase MLL3 contributes to genome-scale circadian transcription. Valekunja UK, et al. Proc Natl Acad Sci U S A, 2013 Jan 22. PMID 23297224, Free PMC Article
    5. Characterization and expression analysis during embryo development of the mouse ortholog of MLL3. Brun ME, et al. Gene, 2006 Apr 12. PMID 16459028

    See all (73) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Macromolecular Complex Including MLL3, Carabin and Calcineurin Regulates Cardiac Remodeling.
      Title: Macromolecular Complex Including MLL3, Carabin and Calcineurin Regulates Cardiac Remodeling.
    2. MLL3/MLL4 methyltransferase activities control early embryonic development and embryonic stem cell differentiation in a lineage-selective manner.
      Title: MLL3/MLL4 methyltransferase activities control early embryonic development and embryonic stem cell differentiation in a lineage-selective manner.
    3. Loss of MLL3/4 decouples enhancer H3K4 monomethylation, H3K27 acetylation, and gene activation during embryonic stem cell differentiation.
      Title: Loss of MLL3/4 decouples enhancer H3K4 monomethylation, H3K27 acetylation, and gene activation during embryonic stem cell differentiation.
    4. Loss of Kmt2c in vivo leads to EMT, mitochondrial dysfunction and improved response to lapatinib in breast cancer.
      Title: Loss of Kmt2c in vivo leads to EMT, mitochondrial dysfunction and improved response to lapatinib in breast cancer.
    5. KMT2C deficiency promotes small cell lung cancer metastasis through DNMT3A-mediated epigenetic reprogramming.
      Title: KMT2C deficiency promotes small cell lung cancer metastasis through DNMT3A-mediated epigenetic reprogramming.
    6. Circadian clock function does not require the histone methyltransferase MLL3.
      Title: Circadian clock function does not require the histone methyltransferase MLL3.
    7. KMT2C methyltransferase domain regulated INK4A expression suppresses prostate cancer metastasis.
      Title: KMT2C methyltransferase domain regulated INK4A expression suppresses prostate cancer metastasis.
    8. Kmt2c mutations enhance HSC self-renewal capacity and convey a selective advantage after chemotherapy.
      Title: Kmt2c mutations enhance HSC self-renewal capacity and convey a selective advantage after chemotherapy.
    9. Long non-coding RNA DANCR regulate MLL3 and thereby it determines the progression of pancreatic cancer.
      Title: Long non-coding RNA DANCR regulate MLL3 and thereby it determines the progression of pancreatic cancer.
    10. MLL4 is required after implantation, whereas MLL3 becomes essential during late gestation.
      Title: MLL4 is required after implantation, whereas MLL3 becomes essential during late gestation.
    Submit: New GeneRIF Correction See all GeneRIFs (27)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1506

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K4 methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H3K4 methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone H3K4 methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables histone H3K4 monomethyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within eyelid development in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of fibroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within single fertilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MLL3/4 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of MLL3/4 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of histone methyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    histone-lysine N-methyltransferase 2C
    Names
    histone-lysine N-methyltransferase MLL3
    myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog
    NP_001074852.1
    XP_006535745.1
    XP_006535746.1
    XP_006535748.1
    XP_006535749.1
    XP_006535751.1
    XP_006535752.1
    XP_006535753.1
    XP_006535755.1
    XP_006535756.1
    XP_006535757.1
    XP_006535759.1
    XP_006535760.1
    XP_006535761.1
    XP_006535762.1
    XP_006535763.1
    XP_006535764.1
    XP_006535766.1
    XP_011248068.1
    XP_017176308.1
    XP_017176309.1
    XP_017176310.1
    XP_017176311.1
    XP_017176312.1
    XP_017176313.1
    XP_017176314.1
    XP_017176315.1
    XP_030110235.1
    XP_036020903.1
    XP_036020904.1
    XP_036020905.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081383.2 → NP_001074852.1  histone-lysine N-methyltransferase 2C

      Status: VALIDATED

      Source sequence(s)
      AC116469, AC127319, AC134910
      Consensus CDS
      CCDS39033.1
      UniProtKB/Swiss-Prot
      Q5YLV9, Q8BK12, Q8BRH4, Q8C6M3, Q923H5, Q923H6
      UniProtKB/TrEMBL
      F8WI37
      Related
      ENSMUSP00000043874.8, ENSMUST00000045291.14
      Conserved Domains (18) summary
      smart00317
      Location:4765 → 4886
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      smart00508
      Location:4888 → 4904
      PostSET; Cysteine-rich motif following a subset of SET domains
      COG2940
      Location:4718 → 4904
      SET; SET domain-containing protein (function unknown) [General function prediction only]
      sd00025
      Location:1078 → 1100
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cd15509
      Location:342 → 387
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15511
      Location:465 → 516
      PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15513
      Location:1003 → 1049
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15594
      Location:389 → 434
      PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15596
      Location:946 → 1002
      PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15600
      Location:1080 → 1130
      PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15696
      Location:246 → 329
      ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
      cd15697
      Location:4395 → 4499
      ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
      pfam05964
      Location:4545 → 4595
      FYRN; F/Y-rich N-terminus
      pfam05965
      Location:4601 → 4682
      FYRC; F/Y rich C-terminus
      pfam07223
      Location:3271 → 3562
      DUF1421; Protein of unknown function (DUF1421)
      pfam11176
      Location:1682 → 1765
      DUF2962; Protein of unknown function (DUF2962)
      pfam15233
      Location:3175 → 3251
      SYCE1; Synaptonemal complex central element protein 1
      cl00082
      Location:1644 → 1695
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      25476793..25703853 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011249766.3 → XP_011248068.1  histone-lysine N-methyltransferase 2C isoform X29

      UniProtKB/Swiss-Prot
      Q5YLV9, Q8BK12, Q8BRH4, Q8C6M3, Q923H5, Q923H6
      Conserved Domains (17) summary
      PHA03247
      Location:1789 → 2279
      PHA03247; large tegument protein UL36; Provisional
      sd00025
      Location:1039 → 1061
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cd15509
      Location:343 → 388
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15511
      Location:466 → 517
      PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15513
      Location:964 → 1010
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15594
      Location:390 → 435
      PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15600
      Location:1041 → 1091
      PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15696
      Location:247 → 330
      ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
      cd15697
      Location:4250 → 4354
      ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
      pfam01576
      Location:3101 → 3183
      Myosin_tail_1; Myosin tail
      pfam03154
      Location:3197 → 3499
      Atrophin-1; Atrophin-1 family
      pfam05964
      Location:4399 → 4450
      FYRN; F/Y-rich N-terminus
      pfam05965
      Location:4456 → 4540
      FYRC; F/Y rich C-terminus
      pfam11176
      Location:1608 → 1691
      Tma16; Translation machinery-associated protein 16
      cd19171
      Location:4602 → 4754
      SET_KMT2C_2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins
      cl00082
      Location:1570 → 1621
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
      cl22851
      Location:907 → 963
      PHD_SF; PHD finger superfamily

    2. XM_036165012.1 → XP_036020905.1  histone-lysine N-methyltransferase 2C isoform X28

      UniProtKB/Swiss-Prot
      Q5YLV9, Q8BK12, Q8BRH4, Q8C6M3, Q923H5, Q923H6
      Conserved Domains (16) summary
      smart00398
      Location:1643 → 1696
      HMG; high mobility group
      PHA03247
      Location:1864 → 2354
      PHA03247; large tegument protein UL36; Provisional
      sd00025
      Location:1079 → 1101
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cd15509
      Location:343 → 388
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15511
      Location:466 → 517
      PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15513
      Location:1004 → 1050
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15594
      Location:390 → 435
      PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15596
      Location:947 → 1003
      PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15600
      Location:1081 → 1131
      PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15696
      Location:247 → 330
      ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
      cd15697
      Location:4451 → 4555
      ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
      pfam09606
      Location:3275 → 3559
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd19171
      Location:4803 → 4955
      SET_KMT2C_2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins
      pfam05964
      Location:4600 → 4651
      FYRN; F/Y-rich N-terminus
      pfam05965
      Location:4657 → 4741
      FYRC; F/Y rich C-terminus
      pfam13868
      Location:3171 → 3258
      TPH; Trichohyalin-plectin-homology domain

    3. XM_006535682.4 → XP_006535745.1  histone-lysine N-methyltransferase 2C isoform X1

      UniProtKB/Swiss-Prot
      Q5YLV9, Q8BK12, Q8BRH4, Q8C6M3, Q923H5, Q923H6
      Conserved Domains (17) summary
      PHA03247
      Location:1880 → 2370
      PHA03247; large tegument protein UL36; Provisional
      sd00025
      Location:1079 → 1101
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cd15509
      Location:343 → 388
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15511
      Location:466 → 517
      PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15513
      Location:1004 → 1050
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15594
      Location:390 → 435
      PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15596
      Location:947 → 1003
      PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15600
      Location:1081 → 1131
      PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15696
      Location:247 → 330
      ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
      cd15697
      Location:4467 → 4571
      ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
      pfam03154
      Location:3288 → 3590
      Atrophin-1; Atrophin-1 family
      pfam05964
      Location:4616 → 4667
      FYRN; F/Y-rich N-terminus
      pfam05965
      Location:4673 → 4757
      FYRC; F/Y rich C-terminus
      pfam11176
      Location:1699 → 1782
      Tma16; Translation machinery-associated protein 16
      pfam12474
      Location:3189 → 3275
      PKK; Polo kinase kinase
      cd19171
      Location:4823 → 4975
      SET_KMT2C_2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins
      cl00082
      Location:1661 → 1712
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

    4. XM_017320819.2 → XP_017176308.1  histone-lysine N-methyltransferase 2C isoform X3

      UniProtKB/Swiss-Prot
      Q5YLV9, Q8BK12, Q8BRH4, Q8C6M3, Q923H5, Q923H6
      Conserved Domains (17) summary
      PHA03247
      Location:1879 → 2369
      PHA03247; large tegument protein UL36; Provisional
      sd00025
      Location:1078 → 1100
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cd15509
      Location:343 → 388
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15511
      Location:466 → 517
      PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15513
      Location:1003 → 1049
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15594
      Location:390 → 435
      PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15596
      Location:946 → 1002
      PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15600
      Location:1080 → 1130
      PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15696
      Location:247 → 330
      ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
      cd15697
      Location:4466 → 4570
      ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
      pfam03154
      Location:3287 → 3589
      Atrophin-1; Atrophin-1 family
      pfam05964
      Location:4615 → 4666
      FYRN; F/Y-rich N-terminus
      pfam05965
      Location:4672 → 4756
      FYRC; F/Y rich C-terminus
      pfam11176
      Location:1698 → 1781
      Tma16; Translation machinery-associated protein 16
      pfam12474
      Location:3188 → 3274
      PKK; Polo kinase kinase
      cd19171
      Location:4822 → 4974
      SET_KMT2C_2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins
      cl00082
      Location:1660 → 1711
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

    5. XM_006535697.4 → XP_006535760.1  histone-lysine N-methyltransferase 2C isoform X19

      UniProtKB/Swiss-Prot
      Q5YLV9, Q8BK12, Q8BRH4, Q8C6M3, Q923H5, Q923H6
      Conserved Domains (17) summary
      PHA03247
      Location:1789 → 2279
      PHA03247; large tegument protein UL36; Provisional
      sd00025
      Location:1039 → 1061
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cd15509
      Location:343 → 388
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15511
      Location:466 → 517
      PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15513
      Location:964 → 1010
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15594
      Location:390 → 435
      PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15596
      Location:907 → 963
      PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15600
      Location:1041 → 1091
      PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15696
      Location:247 → 330
      ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
      cd15697
      Location:4376 → 4480
      ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
      pfam03154
      Location:3197 → 3499
      Atrophin-1; Atrophin-1 family
      pfam05964
      Location:4525 → 4576
      FYRN; F/Y-rich N-terminus
      pfam05965
      Location:4582 → 4666
      FYRC; F/Y rich C-terminus
      pfam11176
      Location:1608 → 1691
      Tma16; Translation machinery-associated protein 16
      pfam12474
      Location:3098 → 3184
      PKK; Polo kinase kinase
      cd19171
      Location:4732 → 4884
      SET_KMT2C_2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins
      cl00082
      Location:1570 → 1621
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

    6. XM_017320824.2 → XP_017176313.1  histone-lysine N-methyltransferase 2C isoform X18

      UniProtKB/Swiss-Prot
      Q5YLV9, Q8BK12, Q8BRH4, Q8C6M3, Q923H5, Q923H6
      Conserved Domains (17) summary
      PHA03247
      Location:1824 → 2314
      PHA03247; large tegument protein UL36; Provisional
      sd00025
      Location:1039 → 1061
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cd15509
      Location:343 → 388
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15511
      Location:466 → 517
      PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15513
      Location:964 → 1010
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15594
      Location:390 → 435
      PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15596
      Location:907 → 963
      PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15600
      Location:1041 → 1091
      PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15696
      Location:247 → 330
      ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
      cd15697
      Location:4411 → 4515
      ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
      pfam03154
      Location:3232 → 3534
      Atrophin-1; Atrophin-1 family
      pfam05964
      Location:4560 → 4611
      FYRN; F/Y-rich N-terminus
      pfam05965
      Location:4617 → 4701
      FYRC; F/Y rich C-terminus
      pfam11176
      Location:1643 → 1726
      Tma16; Translation machinery-associated protein 16
      pfam12474
      Location:3133 → 3219
      PKK; Polo kinase kinase
      cd19171
      Location:4767 → 4919
      SET_KMT2C_2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins
      cl00082
      Location:1605 → 1656
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

    7. XM_006535694.4 → XP_006535757.1  histone-lysine N-methyltransferase 2C isoform X15

      UniProtKB/Swiss-Prot
      Q5YLV9, Q8BK12, Q8BRH4, Q8C6M3, Q923H5, Q923H6
      Conserved Domains (17) summary
      PHA03247
      Location:1840 → 2330
      PHA03247; large tegument protein UL36; Provisional
      sd00025
      Location:1039 → 1061
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cd15509
      Location:343 → 388
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15511
      Location:466 → 517
      PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15513
      Location:964 → 1010
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15594
      Location:390 → 435
      PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15596
      Location:907 → 963
      PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15600
      Location:1041 → 1091
      PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15696
      Location:247 → 330
      ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
      cd15697
      Location:4427 → 4531
      ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
      pfam03154
      Location:3248 → 3550
      Atrophin-1; Atrophin-1 family
      pfam05964
      Location:4576 → 4627
      FYRN; F/Y-rich N-terminus
      pfam05965
      Location:4633 → 4717
      FYRC; F/Y rich C-terminus
      pfam11176
      Location:1659 → 1742
      Tma16; Translation machinery-associated protein 16
      pfam12474
      Location:3149 → 3235
      PKK; Polo kinase kinase
      cd19171
      Location:4783 → 4935
      SET_KMT2C_2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins
      cl00082
      Location:1621 → 1672
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

    8. XM_006535696.4 → XP_006535759.1  histone-lysine N-methyltransferase 2C isoform X17

      UniProtKB/Swiss-Prot
      Q5YLV9, Q8BK12, Q8BRH4, Q8C6M3, Q923H5, Q923H6
      Conserved Domains (17) summary
      PHA03247
      Location:1829 → 2319
      PHA03247; large tegument protein UL36; Provisional
      sd00025
      Location:1079 → 1101
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cd15509
      Location:343 → 388
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15511
      Location:466 → 517
      PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15513
      Location:1004 → 1050
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15594
      Location:390 → 435
      PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15596
      Location:947 → 1003
      PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15600
      Location:1081 → 1131
      PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15696
      Location:247 → 330
      ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
      cd15697
      Location:4416 → 4520
      ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
      pfam03154
      Location:3237 → 3539
      Atrophin-1; Atrophin-1 family
      pfam05964
      Location:4565 → 4616
      FYRN; F/Y-rich N-terminus
      pfam05965
      Location:4622 → 4706
      FYRC; F/Y rich C-terminus
      pfam11176
      Location:1648 → 1731
      Tma16; Translation machinery-associated protein 16
      pfam12474
      Location:3138 → 3224
      PKK; Polo kinase kinase
      cd19171
      Location:4772 → 4924
      SET_KMT2C_2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins
      cl00082
      Location:1610 → 1661
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

    9. XM_006535689.4 → XP_006535752.1  histone-lysine N-methyltransferase 2C isoform X10

      UniProtKB/Swiss-Prot
      Q5YLV9, Q8BK12, Q8BRH4, Q8C6M3, Q923H5, Q923H6
      Conserved Domains (17) summary
      PHA03247
      Location:1864 → 2354
      PHA03247; large tegument protein UL36; Provisional
      sd00025
      Location:1079 → 1101
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cd15509
      Location:343 → 388
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15511
      Location:466 → 517
      PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15513
      Location:1004 → 1050
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15594
      Location:390 → 435
      PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15596
      Location:947 → 1003
      PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15600
      Location:1081 → 1131
      PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15696
      Location:247 → 330
      ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
      cd15697
      Location:4451 → 4555
      ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
      pfam03154
      Location:3272 → 3574
      Atrophin-1; Atrophin-1 family
      pfam05964
      Location:4600 → 4651
      FYRN; F/Y-rich N-terminus
      pfam05965
      Location:4657 → 4741
      FYRC; F/Y rich C-terminus
      pfam11176
      Location:1683 → 1766
      Tma16; Translation machinery-associated protein 16
      pfam12474
      Location:3173 → 3259
      PKK; Polo kinase kinase
      cd19171
      Location:4807 → 4959
      SET_KMT2C_2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins
      cl00082
      Location:1645 → 1696
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

    10. XM_017320826.2 → XP_017176315.1  histone-lysine N-methyltransferase 2C isoform X25

      UniProtKB/Swiss-Prot
      Q5YLV9, Q8BK12, Q8BRH4, Q8C6M3, Q923H5, Q923H6
      Conserved Domains (17) summary
      PHA03247
      Location:1880 → 2370
      PHA03247; large tegument protein UL36; Provisional
      sd00025
      Location:1079 → 1101
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cd15509
      Location:343 → 388
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15511
      Location:466 → 517
      PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15513
      Location:1004 → 1050
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15594
      Location:390 → 435
      PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15596
      Location:947 → 1003
      PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15600
      Location:1081 → 1131
      PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15696
      Location:247 → 330
      ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
      cd15697
      Location:4317 → 4421
      ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
      pfam03154
      Location:3288 → 3590
      Atrophin-1; Atrophin-1 family
      pfam05964
      Location:4466 → 4517
      FYRN; F/Y-rich N-terminus
      pfam05965
      Location:4523 → 4607
      FYRC; F/Y rich C-terminus
      pfam11176
      Location:1699 → 1782
      Tma16; Translation machinery-associated protein 16
      pfam12474
      Location:3189 → 3275
      PKK; Polo kinase kinase
      cd19171
      Location:4669 → 4821
      SET_KMT2C_2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins
      cl00082
      Location:1661 → 1712
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

    11. XM_006535701.4 → XP_006535764.1  histone-lysine N-methyltransferase 2C isoform X24

      UniProtKB/Swiss-Prot
      Q5YLV9, Q8BK12, Q8BRH4, Q8C6M3, Q923H5, Q923H6
      Conserved Domains (17) summary
      PHA03247
      Location:1880 → 2370
      PHA03247; large tegument protein UL36; Provisional
      sd00025
      Location:1079 → 1101
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cd15509
      Location:343 → 388
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15511
      Location:466 → 517
      PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15513
      Location:1004 → 1050
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15594
      Location:390 → 435
      PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15596
      Location:947 → 1003
      PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15600
      Location:1081 → 1131
      PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15696
      Location:247 → 330
      ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
      cd15697
      Location:4317 → 4421
      ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
      pfam03154
      Location:3288 → 3590
      Atrophin-1; Atrophin-1 family
      pfam05964
      Location:4466 → 4517
      FYRN; F/Y-rich N-terminus
      pfam05965
      Location:4523 → 4607
      FYRC; F/Y rich C-terminus
      pfam11176
      Location:1699 → 1782
      Tma16; Translation machinery-associated protein 16
      pfam12474
      Location:3189 → 3275
      PKK; Polo kinase kinase
      cd19171
      Location:4673 → 4825
      SET_KMT2C_2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins
      cl00082
      Location:1661 → 1712
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

    12. XM_017320825.2 → XP_017176314.1  histone-lysine N-methyltransferase 2C isoform X23

      UniProtKB/Swiss-Prot
      Q5YLV9, Q8BK12, Q8BRH4, Q8C6M3, Q923H5, Q923H6
      Conserved Domains (17) summary
      PHA03247
      Location:1880 → 2370
      PHA03247; large tegument protein UL36; Provisional
      sd00025
      Location:1079 → 1101
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cd15509
      Location:343 → 388
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15511
      Location:466 → 517
      PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15513
      Location:1004 → 1050
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15594
      Location:390 → 435
      PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15596
      Location:947 → 1003
      PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15600
      Location:1081 → 1131
      PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15696
      Location:247 → 330
      ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
      cd15697
      Location:4340 → 4444
      ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
      pfam03154
      Location:3288 → 3590
      Atrophin-1; Atrophin-1 family
      pfam05964
      Location:4489 → 4540
      FYRN; F/Y-rich N-terminus
      pfam05965
      Location:4546 → 4630
      FYRC; F/Y rich C-terminus
      pfam11176
      Location:1699 → 1782
      Tma16; Translation machinery-associated protein 16
      pfam12474
      Location:3189 → 3275
      PKK; Polo kinase kinase
      cd19171
      Location:4692 → 4844
      SET_KMT2C_2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins
      cl00082
      Location:1661 → 1712
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

    13. XM_006535699.4 → XP_006535762.1  histone-lysine N-methyltransferase 2C isoform X21

      UniProtKB/Swiss-Prot
      Q5YLV9, Q8BK12, Q8BRH4, Q8C6M3, Q923H5, Q923H6
      Conserved Domains (17) summary
      PHA03247
      Location:1880 → 2370
      PHA03247; large tegument protein UL36; Provisional
      sd00025
      Location:1079 → 1101
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cd15509
      Location:343 → 388
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15511
      Location:466 → 517
      PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15513
      Location:1004 → 1050
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15594
      Location:390 → 435
      PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15596
      Location:947 → 1003
      PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15600
      Location:1081 → 1131
      PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15696
      Location:247 → 330
      ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
      cd15697
      Location:4340 → 4444
      ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
      pfam03154
      Location:3288 → 3590
      Atrophin-1; Atrophin-1 family
      pfam05964
      Location:4489 → 4540
      FYRN; F/Y-rich N-terminus
      pfam05965
      Location:4546 → 4630
      FYRC; F/Y rich C-terminus
      pfam11176
      Location:1699 → 1782
      Tma16; Translation machinery-associated protein 16
      pfam12474
      Location:3189 → 3275
      PKK; Polo kinase kinase
      cd19171
      Location:4696 → 4848
      SET_KMT2C_2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins
      cl00082
      Location:1661 → 1712
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

    14. XM_006535700.4 → XP_006535763.1  histone-lysine N-methyltransferase 2C isoform X22

      UniProtKB/Swiss-Prot
      Q5YLV9, Q8BK12, Q8BRH4, Q8C6M3, Q923H5, Q923H6
      Conserved Domains (17) summary
      PHA03247
      Location:1880 → 2370
      PHA03247; large tegument protein UL36; Provisional
      sd00025
      Location:1079 → 1101
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cd15509
      Location:343 → 388
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15511
      Location:466 → 517
      PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15513
      Location:1004 → 1050
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15594
      Location:390 → 435
      PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15596
      Location:947 → 1003
      PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15600
      Location:1081 → 1131
      PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15696
      Location:247 → 330
      ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
      cd15697
      Location:4341 → 4445
      ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
      pfam03154
      Location:3288 → 3590
      Atrophin-1; Atrophin-1 family
      pfam05964
      Location:4490 → 4541
      FYRN; F/Y-rich N-terminus
      pfam05965
      Location:4547 → 4631
      FYRC; F/Y rich C-terminus
      pfam11176
      Location:1699 → 1782
      Tma16; Translation machinery-associated protein 16
      pfam12474
      Location:3189 → 3275
      PKK; Polo kinase kinase
      cd19171
      Location:4693 → 4845
      SET_KMT2C_2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins
      cl00082
      Location:1661 → 1712
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

    15. XM_006535698.4 → XP_006535761.1  histone-lysine N-methyltransferase 2C isoform X20

      UniProtKB/Swiss-Prot
      Q5YLV9, Q8BK12, Q8BRH4, Q8C6M3, Q923H5, Q923H6
      Conserved Domains (17) summary
      PHA03247
      Location:1880 → 2370
      PHA03247; large tegument protein UL36; Provisional
      sd00025
      Location:1079 → 1101
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cd15509
      Location:343 → 388
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15511
      Location:466 → 517
      PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15513
      Location:1004 → 1050
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15594
      Location:390 → 435
      PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15596
      Location:947 → 1003
      PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15600
      Location:1081 → 1131
      PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15696
      Location:247 → 330
      ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
      cd15697
      Location:4341 → 4445
      ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
      pfam03154
      Location:3288 → 3590
      Atrophin-1; Atrophin-1 family
      pfam05964
      Location:4490 → 4541
      FYRN; F/Y-rich N-terminus
      pfam05965
      Location:4547 → 4631
      FYRC; F/Y rich C-terminus
      pfam11176
      Location:1699 → 1782
      Tma16; Translation machinery-associated protein 16
      pfam12474
      Location:3189 → 3275
      PKK; Polo kinase kinase
      cd19171
      Location:4697 → 4849
      SET_KMT2C_2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins
      cl00082
      Location:1661 → 1712
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

    16. XM_017320823.2 → XP_017176312.1  histone-lysine N-methyltransferase 2C isoform X13

      UniProtKB/Swiss-Prot
      Q5YLV9, Q8BK12, Q8BRH4, Q8C6M3, Q923H5, Q923H6
      Conserved Domains (17) summary
      PHA03247
      Location:1880 → 2370
      PHA03247; large tegument protein UL36; Provisional
      sd00025
      Location:1079 → 1101
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cd15509
      Location:343 → 388
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15511
      Location:466 → 517
      PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15513
      Location:1004 → 1050
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15594
      Location:390 → 435
      PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15596
      Location:947 → 1003
      PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15600
      Location:1081 → 1131
      PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15696
      Location:247 → 330
      ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
      cd15697
      Location:4442 → 4546
      ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
      pfam03154
      Location:3288 → 3590
      Atrophin-1; Atrophin-1 family
      pfam05964
      Location:4591 → 4642
      FYRN; F/Y-rich N-terminus
      pfam05965
      Location:4648 → 4732
      FYRC; F/Y rich C-terminus
      pfam11176
      Location:1699 → 1782
      Tma16; Translation machinery-associated protein 16
      pfam12474
      Location:3189 → 3275
      PKK; Polo kinase kinase
      cd19171
      Location:4798 → 4950
      SET_KMT2C_2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins
      cl00082
      Location:1661 → 1712
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

    17. XM_017320821.2 → XP_017176310.1  histone-lysine N-methyltransferase 2C isoform X8

      UniProtKB/Swiss-Prot
      Q5YLV9, Q8BK12, Q8BRH4, Q8C6M3, Q923H5, Q923H6
      Conserved Domains (17) summary
      PHA03247
      Location:1880 → 2370
      PHA03247; large tegument protein UL36; Provisional
      sd00025
      Location:1079 → 1101
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cd15509
      Location:343 → 388
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15511
      Location:466 → 517
      PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15513
      Location:1004 → 1050
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15594
      Location:390 → 435
      PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15596
      Location:947 → 1003
      PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15600
      Location:1081 → 1131
      PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15696
      Location:247 → 330
      ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
      cd15697
      Location:4466 → 4570
      ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
      pfam03154
      Location:3288 → 3590
      Atrophin-1; Atrophin-1 family
      pfam05964
      Location:4615 → 4666
      FYRN; F/Y-rich N-terminus
      pfam05965
      Location:4672 → 4756
      FYRC; F/Y rich C-terminus
      pfam11176
      Location:1699 → 1782
      Tma16; Translation machinery-associated protein 16
      pfam12474
      Location:3189 → 3275
      PKK; Polo kinase kinase
      cd19171
      Location:4818 → 4970
      SET_KMT2C_2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins
      cl00082
      Location:1661 → 1712
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

    18. XM_006535685.4 → XP_006535748.1  histone-lysine N-methyltransferase 2C isoform X4

      UniProtKB/Swiss-Prot
      Q5YLV9, Q8BK12, Q8BRH4, Q8C6M3, Q923H5, Q923H6
      Conserved Domains (17) summary
      PHA03247
      Location:1880 → 2370
      PHA03247; large tegument protein UL36; Provisional
      sd00025
      Location:1079 → 1101
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cd15509
      Location:343 → 388
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15511
      Location:466 → 517
      PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15513
      Location:1004 → 1050
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15594
      Location:390 → 435
      PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15596
      Location:947 → 1003
      PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15600
      Location:1081 → 1131
      PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15696
      Location:247 → 330
      ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
      cd15697
      Location:4466 → 4570
      ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
      pfam03154
      Location:3288 → 3590
      Atrophin-1; Atrophin-1 family
      pfam05964
      Location:4615 → 4666
      FYRN; F/Y-rich N-terminus
      pfam05965
      Location:4672 → 4756
      FYRC; F/Y rich C-terminus
      pfam11176
      Location:1699 → 1782
      Tma16; Translation machinery-associated protein 16
      pfam12474
      Location:3189 → 3275
      PKK; Polo kinase kinase
      cd19171
      Location:4822 → 4974
      SET_KMT2C_2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins
      cl00082
      Location:1661 → 1712
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

    19. XM_006535693.4 → XP_006535756.1  histone-lysine N-methyltransferase 2C isoform X14

      UniProtKB/Swiss-Prot
      Q5YLV9, Q8BK12, Q8BRH4, Q8C6M3, Q923H5, Q923H6
      Conserved Domains (17) summary
      PHA03247
      Location:1880 → 2370
      PHA03247; large tegument protein UL36; Provisional
      sd00025
      Location:1079 → 1101
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cd15509
      Location:343 → 388
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15511
      Location:466 → 517
      PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15513
      Location:1004 → 1050
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15594
      Location:390 → 435
      PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15596
      Location:947 → 1003
      PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15600
      Location:1081 → 1131
      PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15696
      Location:247 → 330
      ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
      cd15697
      Location:4443 → 4547
      ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
      pfam03154
      Location:3288 → 3590
      Atrophin-1; Atrophin-1 family
      pfam05964
      Location:4592 → 4643
      FYRN; F/Y-rich N-terminus
      pfam05965
      Location:4649 → 4733
      FYRC; F/Y rich C-terminus
      pfam11176
      Location:1699 → 1782
      Tma16; Translation machinery-associated protein 16
      pfam12474
      Location:3189 → 3275
      PKK; Polo kinase kinase
      cd19171
      Location:4795 → 4947
      SET_KMT2C_2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins
      cl00082
      Location:1661 → 1712
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

    20. XM_006535692.4 → XP_006535755.1  histone-lysine N-methyltransferase 2C isoform X12

      UniProtKB/Swiss-Prot
      Q5YLV9, Q8BK12, Q8BRH4, Q8C6M3, Q923H5, Q923H6
      Conserved Domains (17) summary
      PHA03247
      Location:1880 → 2370
      PHA03247; large tegument protein UL36; Provisional
      sd00025
      Location:1079 → 1101
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cd15509
      Location:343 → 388
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15511
      Location:466 → 517
      PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15513
      Location:1004 → 1050
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15594
      Location:390 → 435
      PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15596
      Location:947 → 1003
      PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15600
      Location:1081 → 1131
      PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15696
      Location:247 → 330
      ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
      cd15697
      Location:4443 → 4547
      ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
      pfam03154
      Location:3288 → 3590
      Atrophin-1; Atrophin-1 family
      pfam05964
      Location:4592 → 4643
      FYRN; F/Y-rich N-terminus
      pfam05965
      Location:4649 → 4733
      FYRC; F/Y rich C-terminus
      pfam11176
      Location:1699 → 1782
      Tma16; Translation machinery-associated protein 16
      pfam12474
      Location:3189 → 3275
      PKK; Polo kinase kinase
      cd19171
      Location:4799 → 4951
      SET_KMT2C_2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins
      cl00082
      Location:1661 → 1712
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

    21. XM_017320822.2 → XP_017176311.1  histone-lysine N-methyltransferase 2C isoform X9

      UniProtKB/Swiss-Prot
      Q5YLV9, Q8BK12, Q8BRH4, Q8C6M3, Q923H5, Q923H6
      Conserved Domains (17) summary
      PHA03247
      Location:1880 → 2370
      PHA03247; large tegument protein UL36; Provisional
      sd00025
      Location:1079 → 1101
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cd15509
      Location:343 → 388
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15511
      Location:466 → 517
      PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15513
      Location:1004 → 1050
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15594
      Location:390 → 435
      PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15596
      Location:947 → 1003
      PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15600
      Location:1081 → 1131
      PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15696
      Location:247 → 330
      ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
      cd15697
      Location:4466 → 4570
      ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
      pfam03154
      Location:3288 → 3590
      Atrophin-1; Atrophin-1 family
      pfam05964
      Location:4615 → 4666
      FYRN; F/Y-rich N-terminus
      pfam05965
      Location:4672 → 4756
      FYRC; F/Y rich C-terminus
      pfam11176
      Location:1699 → 1782
      Tma16; Translation machinery-associated protein 16
      pfam12474
      Location:3189 → 3275
      PKK; Polo kinase kinase
      cd19171
      Location:4818 → 4970
      SET_KMT2C_2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins
      cl00082
      Location:1661 → 1712
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

    22. XM_006535686.4 → XP_006535749.1  histone-lysine N-methyltransferase 2C isoform X5

      UniProtKB/Swiss-Prot
      Q5YLV9, Q8BK12, Q8BRH4, Q8C6M3, Q923H5, Q923H6
      Conserved Domains (17) summary
      PHA03247
      Location:1880 → 2370
      PHA03247; large tegument protein UL36; Provisional
      sd00025
      Location:1079 → 1101
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cd15509
      Location:343 → 388
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15511
      Location:466 → 517
      PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15513
      Location:1004 → 1050
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15594
      Location:390 → 435
      PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15596
      Location:947 → 1003
      PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15600
      Location:1081 → 1131
      PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15696
      Location:247 → 330
      ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
      cd15697
      Location:4466 → 4570
      ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
      pfam03154
      Location:3288 → 3590
      Atrophin-1; Atrophin-1 family
      pfam05964
      Location:4615 → 4666
      FYRN; F/Y-rich N-terminus
      pfam05965
      Location:4672 → 4756
      FYRC; F/Y rich C-terminus
      pfam11176
      Location:1699 → 1782
      Tma16; Translation machinery-associated protein 16
      pfam12474
      Location:3189 → 3275
      PKK; Polo kinase kinase
      cd19171
      Location:4822 → 4974
      SET_KMT2C_2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins
      cl00082
      Location:1661 → 1712
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

    23. XM_006535688.4 → XP_006535751.1  histone-lysine N-methyltransferase 2C isoform X7

      UniProtKB/Swiss-Prot
      Q5YLV9, Q8BK12, Q8BRH4, Q8C6M3, Q923H5, Q923H6
      Conserved Domains (17) summary
      PHA03247
      Location:1880 → 2370
      PHA03247; large tegument protein UL36; Provisional
      sd00025
      Location:1079 → 1101
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cd15509
      Location:343 → 388
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15511
      Location:466 → 517
      PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15513
      Location:1004 → 1050
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15594
      Location:390 → 435
      PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15596
      Location:947 → 1003
      PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15600
      Location:1081 → 1131
      PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15696
      Location:247 → 330
      ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
      cd15697
      Location:4467 → 4571
      ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
      pfam03154
      Location:3288 → 3590
      Atrophin-1; Atrophin-1 family
      pfam05964
      Location:4616 → 4667
      FYRN; F/Y-rich N-terminus
      pfam05965
      Location:4673 → 4757
      FYRC; F/Y rich C-terminus
      pfam11176
      Location:1699 → 1782
      Tma16; Translation machinery-associated protein 16
      pfam12474
      Location:3189 → 3275
      PKK; Polo kinase kinase
      cd19171
      Location:4819 → 4971
      SET_KMT2C_2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins
      cl00082
      Location:1661 → 1712
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

    24. XM_017320820.3 → XP_017176309.1  histone-lysine N-methyltransferase 2C isoform X6

      UniProtKB/Swiss-Prot
      Q5YLV9, Q8BK12, Q8BRH4, Q8C6M3, Q923H5, Q923H6
      Conserved Domains (17) summary
      PHA03247
      Location:1878 → 2368
      PHA03247; large tegument protein UL36; Provisional
      sd00025
      Location:1077 → 1099
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cd15509
      Location:342 → 387
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15511
      Location:465 → 516
      PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15513
      Location:1002 → 1048
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15594
      Location:389 → 434
      PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15596
      Location:945 → 1001
      PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15600
      Location:1079 → 1129
      PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15696
      Location:246 → 329
      ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
      cd15697
      Location:4465 → 4569
      ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
      pfam03154
      Location:3286 → 3588
      Atrophin-1; Atrophin-1 family
      pfam05964
      Location:4614 → 4665
      FYRN; F/Y-rich N-terminus
      pfam05965
      Location:4671 → 4755
      FYRC; F/Y rich C-terminus
      pfam11176
      Location:1697 → 1780
      Tma16; Translation machinery-associated protein 16
      pfam12474
      Location:3187 → 3273
      PKK; Polo kinase kinase
      cd19171
      Location:4821 → 4973
      SET_KMT2C_2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins
      cl00082
      Location:1659 → 1710
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

    25. XM_030254375.2 → XP_030110235.1  histone-lysine N-methyltransferase 2C isoform X16

      UniProtKB/Swiss-Prot
      Q5YLV9, Q8BK12, Q8BRH4, Q8C6M3, Q923H5, Q923H6
      Conserved Domains (17) summary
      PHA03247
      Location:1839 → 2329
      PHA03247; large tegument protein UL36; Provisional
      sd00025
      Location:1038 → 1060
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cd15509
      Location:342 → 387
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15511
      Location:465 → 516
      PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15513
      Location:963 → 1009
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15594
      Location:389 → 434
      PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15596
      Location:906 → 962
      PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15600
      Location:1040 → 1090
      PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15696
      Location:246 → 329
      ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
      cd15697
      Location:4426 → 4530
      ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
      pfam03154
      Location:3247 → 3549
      Atrophin-1; Atrophin-1 family
      pfam05964
      Location:4575 → 4626
      FYRN; F/Y-rich N-terminus
      pfam05965
      Location:4632 → 4716
      FYRC; F/Y rich C-terminus
      pfam11176
      Location:1658 → 1741
      Tma16; Translation machinery-associated protein 16
      pfam12474
      Location:3148 → 3234
      PKK; Polo kinase kinase
      cd19171
      Location:4782 → 4934
      SET_KMT2C_2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins
      cl00082
      Location:1620 → 1671
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

    26. XM_006535690.5 → XP_006535753.1  histone-lysine N-methyltransferase 2C isoform X11

      UniProtKB/Swiss-Prot
      Q5YLV9, Q8BK12, Q8BRH4, Q8C6M3, Q923H5, Q923H6
      Conserved Domains (17) summary
      PHA03247
      Location:1863 → 2353
      PHA03247; large tegument protein UL36; Provisional
      sd00025
      Location:1078 → 1100
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cd15509
      Location:342 → 387
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15511
      Location:465 → 516
      PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15513
      Location:1003 → 1049
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15594
      Location:389 → 434
      PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15596
      Location:946 → 1002
      PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15600
      Location:1080 → 1130
      PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15696
      Location:246 → 329
      ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
      cd15697
      Location:4450 → 4554
      ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
      pfam03154
      Location:3271 → 3573
      Atrophin-1; Atrophin-1 family
      pfam05964
      Location:4599 → 4650
      FYRN; F/Y-rich N-terminus
      pfam05965
      Location:4656 → 4740
      FYRC; F/Y rich C-terminus
      pfam11176
      Location:1682 → 1765
      Tma16; Translation machinery-associated protein 16
      pfam12474
      Location:3172 → 3258
      PKK; Polo kinase kinase
      cd19171
      Location:4806 → 4958
      SET_KMT2C_2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins
      cl00082
      Location:1644 → 1695
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

    27. XM_006535683.5 → XP_006535746.1  histone-lysine N-methyltransferase 2C isoform X2

      UniProtKB/Swiss-Prot
      Q5YLV9, Q8BK12, Q8BRH4, Q8C6M3, Q923H5, Q923H6
      Conserved Domains (17) summary
      PHA03247
      Location:1879 → 2369
      PHA03247; large tegument protein UL36; Provisional
      sd00025
      Location:1078 → 1100
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cd15509
      Location:342 → 387
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15511
      Location:465 → 516
      PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15513
      Location:1003 → 1049
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15594
      Location:389 → 434
      PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15596
      Location:946 → 1002
      PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15600
      Location:1080 → 1130
      PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15696
      Location:246 → 329
      ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
      cd15697
      Location:4466 → 4570
      ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
      pfam03154
      Location:3287 → 3589
      Atrophin-1; Atrophin-1 family
      pfam05964
      Location:4615 → 4666
      FYRN; F/Y-rich N-terminus
      pfam05965
      Location:4672 → 4756
      FYRC; F/Y rich C-terminus
      pfam11176
      Location:1698 → 1781
      Tma16; Translation machinery-associated protein 16
      pfam12474
      Location:3188 → 3274
      PKK; Polo kinase kinase
      cd19171
      Location:4822 → 4974
      SET_KMT2C_2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins
      cl00082
      Location:1660 → 1711
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

    28. XM_036165011.1 → XP_036020904.1  histone-lysine N-methyltransferase 2C isoform X26

      Conserved Domains (7) summary
      smart00398
      Location:154 → 207
      HMG; high mobility group
      PHA03247
      Location:375 → 865
      PHA03247; large tegument protein UL36; Provisional
      cd15697
      Location:2962 → 3066
      ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
      cd19171
      Location:3318 → 3470
      SET_KMT2C_2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins
      pfam05964
      Location:3111 → 3162
      FYRN; F/Y-rich N-terminus
      pfam05965
      Location:3168 → 3252
      FYRC; F/Y rich C-terminus
      pfam13868
      Location:1682 → 1769
      TPH; Trichohyalin-plectin-homology domain

    29. XM_036165010.1 → XP_036020903.1  histone-lysine N-methyltransferase 2C isoform X26

      Conserved Domains (7) summary
      smart00398
      Location:154 → 207
      HMG; high mobility group
      PHA03247
      Location:375 → 865
      PHA03247; large tegument protein UL36; Provisional
      cd15697
      Location:2962 → 3066
      ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
      cd19171
      Location:3318 → 3470
      SET_KMT2C_2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins
      pfam05964
      Location:3111 → 3162
      FYRN; F/Y-rich N-terminus
      pfam05965
      Location:3168 → 3252
      FYRC; F/Y rich C-terminus
      pfam13868
      Location:1682 → 1769
      TPH; Trichohyalin-plectin-homology domain

    30. XM_006535703.3 → XP_006535766.1  histone-lysine N-methyltransferase 2C isoform X27

      Conserved Domains (11) summary
      PHA03247
      Location:1880 → 2370
      PHA03247; large tegument protein UL36; Provisional
      sd00025
      Location:1079 → 1101
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cd15509
      Location:343 → 388
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15511
      Location:466 → 517
      PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15513
      Location:1004 → 1050
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15594
      Location:390 → 435
      PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15600
      Location:1081 → 1131
      PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15696
      Location:247 → 330
      ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
      pfam11176
      Location:1699 → 1782
      Tma16; Translation machinery-associated protein 16
      cl00082
      Location:1661 → 1712
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
      cl22851
      Location:947 → 1003
      PHD_SF; PHD finger superfamily

    RNA

    1. XR_003955625.1 RNA Sequence

    2. XR_001784670.2 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_177283.2: Suppressed sequence

      Description
      NM_177283.2: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BRH4.2 GenPept UniProtKB/Swiss-Prot:Q8BRH4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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