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    Fbxo44 F-box protein 44 [ Mus musculus (house mouse) ]

    Gene ID: 230903, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Fbxo44provided by MGI
    Official Full Name
    F-box protein 44provided by MGI
    Primary source
    MGI:MGI:1354744
    See related
    Ensembl:ENSMUSG00000029001 AllianceGenome:MGI:1354744
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FBG3; FBX30; Fbx6a; Fbxo6a; 5730411K09
    Summary
    Predicted to contribute to ubiquitin protein ligase activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; glycoprotein catabolic process; and ubiquitin-dependent ERAD pathway. Predicted to act upstream of or within proteasomal protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in brain; gut; and male reproductive gland or organ. Orthologous to human FBXO44 (F-box protein 44). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis adult (RPKM 49.7), cerebellum adult (RPKM 30.0) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 E2; 4 78.67 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (148237256..148244663, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (148152799..148160183, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene dorsal inhibitory axon guidance protein Neighboring gene STARR-positive B cell enhancer ABC_E2146 Neighboring gene MAD2 mitotic arrest deficient-like 2 Neighboring gene STARR-positive B cell enhancer ABC_E4728 Neighboring gene microRNA 7022 Neighboring gene STARR-positive B cell enhancer ABC_E3553 Neighboring gene F-box protein 6 Neighboring gene F-box protein 2 Neighboring gene STARR-seq mESC enhancer starr_12077 Neighboring gene predicted gene, 32603 Neighboring gene dispatched RND transporter family member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. FBXO44-Mediated Degradation of RGS2 Protein Uniquely Depends on a Cullin 4B/DDB1 Complex. Sjögren B, et al. PLoS One, 2015. PMID 25970626, Free PMC Article
    2. Transcriptome Analysis of Targeted Mouse Mutations Reveals the Topography of Local Changes in Gene Expression. West DB, et al. PLoS Genet, 2016 Feb. PMID 26839965, Free PMC Article
    3. A family of mammalian F-box proteins. Winston JT, et al. Curr Biol, 1999 Oct 21. PMID 10531037
    4. Systematic analysis and nomenclature of mammalian F-box proteins. Jin J, et al. Genes Dev, 2004 Nov 1. PMID 15520277, Free PMC Article
    5. Novel protein interactions with endoglin and activin receptor-like kinase 1: potential role in vascular networks. Xu G, et al. Mol Cell Proteomics, 2014 Feb. PMID 24319055, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FBXO44-mediated degradation of RGS2 protein uniquely depends on a Cul4B/DDB1 complex.
      Title: FBXO44-Mediated Degradation of RGS2 Protein Uniquely Depends on a Cullin 4B/DDB1 Complex.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    contributes_to ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycoprotein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within proteasomal protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SCF ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    F-box only protein 44
    Names
    F-box only protein 6a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001161851.2 → NP_001155323.1  F-box only protein 44 isoform 1

      See identical proteins and their annotated locations for NP_001155323.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Both variants 1 and 3 encode isoform 1.
      Source sequence(s)
      AK077452, BP761336, BQ042735, BY292524
      Consensus CDS
      CCDS18934.1
      UniProtKB/Swiss-Prot
      Q8BK26, Q8K128
      UniProtKB/TrEMBL
      A2A7H5
      Related
      ENSMUSP00000126551.2, ENSMUST00000167160.8
      Conserved Domains (2) summary
      pfam04300
      Location:72 → 248
      FBA; F-box associated region
      pfam12937
      Location:6 → 51
      F-box-like

    2. NM_001161852.2 → NP_001155324.1  F-box only protein 44 isoform 2

      See identical proteins and their annotated locations for NP_001155324.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site and lacks an internal exon, resulting in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus and lacks an F-box-associated domain, compared to isoform 1.
      Source sequence(s)
      AK077452, BM932876, BP761336, BQ042735, BY128919, BY252242
      Consensus CDS
      CCDS51377.1
      UniProtKB/TrEMBL
      A2A7H6
      Related
      ENSMUSP00000101330.3, ENSMUST00000105705.9
      Conserved Domains (2) summary
      pfam04300
      Location:72 → 122
      FBA; F-box associated region
      pfam12937
      Location:6 → 51
      F-box-like

    3. NM_001355701.1 → NP_001342630.1  F-box only protein 44 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL606929, BM932876, BQ042735, BY128919, BY252242
      UniProtKB/TrEMBL
      E9PUJ0
      Conserved Domains (2) summary
      pfam04300
      Location:72 → 208
      FBA; F-box associated region
      pfam12937
      Location:6 → 51
      F-box-like; F-box-like

    4. NM_001355702.1 → NP_001342631.1  F-box only protein 44 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL606929, BM932876, BQ042735, BY128919, BY252242
      UniProtKB/TrEMBL
      F6UI76
      Conserved Domains (1) summary
      pfam04300
      Location:13 → 132
      FBA; F-box associated region

    5. NM_173401.5 → NP_775577.2  F-box only protein 44 isoform 1

      See identical proteins and their annotated locations for NP_775577.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Both variants 1 and 3 encode the same isoform.
      Source sequence(s)
      AK077452, BP761336, BQ042735, BY128919, BY252242
      Consensus CDS
      CCDS18934.1
      UniProtKB/Swiss-Prot
      Q8BK26, Q8K128
      UniProtKB/TrEMBL
      A2A7H5
      Related
      ENSMUSP00000054022.3, ENSMUST00000057907.10
      Conserved Domains (2) summary
      pfam04300
      Location:72 → 248
      FBA; F-box associated region
      pfam12937
      Location:6 → 51
      F-box-like

    RNA

    1. NR_104374.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) includes an alternate 5' terminal exon and an additional exon in the 3' region, compared to variant 1. This variant is represented as non-coding because use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK077452, AL606929, BP761336, BY252242, CX202860
      Related
      ENSMUST00000129253.8

    2. NR_104375.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks a 5' exon and includes an additional exon in the 3' region, compared to variant 1. This variant is represented as non-coding because use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK077452, BP761336, BY252242, CX202860

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      148237256..148244663 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030253501.2 → XP_030109361.1  F-box only protein 44 isoform X2

      UniProtKB/TrEMBL
      A2A7H6
      Conserved Domains (2) summary
      pfam04300
      Location:72 → 122
      FBA; F-box associated region
      pfam12937
      Location:6 → 51
      F-box-like

    2. XM_017320176.2 → XP_017175665.1  F-box only protein 44 isoform X1

      UniProtKB/Swiss-Prot
      Q8BK26, Q8K128
      UniProtKB/TrEMBL
      A2A7H5
      Conserved Domains (2) summary
      pfam04300
      Location:72 → 248
      FBA; F-box associated region
      pfam12937
      Location:6 → 51
      F-box-like

    3. XM_030253508.1 → XP_030109368.1  F-box only protein 44 isoform X3

      Conserved Domains (1) summary
      pfam04300
      Location:13 → 172
      FBA; F-box associated region

    4. XM_030253504.2 → XP_030109364.1  F-box only protein 44 isoform X3

      Conserved Domains (1) summary
      pfam04300
      Location:13 → 172
      FBA; F-box associated region

    5. XM_017320180.3 → XP_017175669.1  F-box only protein 44 isoform X4

      Conserved Domains (1) summary
      pfam04300
      Location:13 → 46
      FBA; F-box associated region

    6. XM_030253500.2 → XP_030109360.1  F-box only protein 44 isoform X2

      UniProtKB/TrEMBL
      A2A7H6
      Conserved Domains (2) summary
      pfam04300
      Location:72 → 122
      FBA; F-box associated region
      pfam12937
      Location:6 → 51
      F-box-like

    7. XM_030253507.2 → XP_030109367.1  F-box only protein 44 isoform X3

      Conserved Domains (1) summary
      pfam04300
      Location:13 → 172
      FBA; F-box associated region

    8. XM_030253506.2 → XP_030109366.1  F-box only protein 44 isoform X3

      Conserved Domains (1) summary
      pfam04300
      Location:13 → 172
      FBA; F-box associated region

    9. XM_030253505.2 → XP_030109365.1  F-box only protein 44 isoform X3

      Conserved Domains (1) summary
      pfam04300
      Location:13 → 172
      FBA; F-box associated region

    10. XM_017320178.3 → XP_017175667.1  F-box only protein 44 isoform X1

      UniProtKB/Swiss-Prot
      Q8BK26, Q8K128
      UniProtKB/TrEMBL
      A2A7H5
      Conserved Domains (2) summary
      pfam04300
      Location:72 → 248
      FBA; F-box associated region
      pfam12937
      Location:6 → 51
      F-box-like

    11. XM_030253503.2 → XP_030109363.1  F-box only protein 44 isoform X2

      UniProtKB/TrEMBL
      A2A7H6
      Conserved Domains (2) summary
      pfam04300
      Location:72 → 122
      FBA; F-box associated region
      pfam12937
      Location:6 → 51
      F-box-like

    12. XM_030253502.2 → XP_030109362.1  F-box only protein 44 isoform X2

      UniProtKB/TrEMBL
      A2A7H6
      Conserved Domains (2) summary
      pfam04300
      Location:72 → 122
      FBA; F-box associated region
      pfam12937
      Location:6 → 51
      F-box-like

    13. XM_017320177.2 → XP_017175666.1  F-box only protein 44 isoform X1

      UniProtKB/Swiss-Prot
      Q8BK26, Q8K128
      UniProtKB/TrEMBL
      A2A7H5
      Conserved Domains (2) summary
      pfam04300
      Location:72 → 248
      FBA; F-box associated region
      pfam12937
      Location:6 → 51
      F-box-like

    RNA

    1. XR_004941881.1 RNA Sequence

    2. XR_003954936.2 RNA Sequence

    3. XR_003954934.2 RNA Sequence

    4. XR_881428.4 RNA Sequence

    5. XR_004941880.1 RNA Sequence

    6. XR_004941883.1 RNA Sequence

    7. XR_003954933.2 RNA Sequence

    8. XR_003954935.2 RNA Sequence

    9. XR_003954937.2 RNA Sequence

    10. XR_004941882.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BK26.1 GenPept UniProtKB/Swiss-Prot:Q8BK26

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