Sh2d5 SH2 domain containing 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sh2d5provided by MGI
Official Full Name: SH2 domain containing 5provided by MGI
Primary source: MGI:MGI:2446215
See related: Ensembl:ENSMUSG00000045349 AllianceGenome:MGI:2446215
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Located in postsynaptic density. Orthologous to human SH2D5 (SH2 domain containing 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cortex adult (RPKM 20.0), frontal lobe adult (RPKM 15.1) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D3; 4 70.07 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (137977722..137988279)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (138250411..138260968)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)
Endonuclease-mediated (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
is_active_in postsynaptic density	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: SH2 domain-containing protein 5

Names: vascular SH2 domain-containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001099631.1 → NP_001093101.1 SH2 domain-containing protein 5

See identical proteins and their annotated locations for NP_001093101.1

Status: PROVISIONAL

Source sequence(s)

DQ832275

Consensus CDS

CCDS51335.1

UniProtKB/Swiss-Prot

Q8JZW5

UniProtKB/TrEMBL

A2AM67

Related

ENSMUSP00000101450.2, ENSMUST00000105824.8

Conserved Domains (2) summary

cd00173
Location:302 → 378

SH2; Src homology 2 (SH2) domain

cd13157
Location:23 → 150

PTB_tensin-related; Tensin-related Phosphotyrosine-binding (PTB) domain