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    Ncmap noncompact myelin associated protein [ Mus musculus (house mouse) ]

    Gene ID: 230822, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Ncmapprovided by MGI
    Official Full Name
    noncompact myelin associated proteinprovided by MGI
    Primary source
    MGI:MGI:2444888
    See related
    Ensembl:ENSMUSG00000043924 AllianceGenome:MGI:2444888
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mp11; A330049M08Rik
    Summary
    Predicted to be a structural constituent of myelin sheath. Predicted to be involved in peripheral nervous system myelin formation and positive regulation of myelination. Is integral component of plasma membrane. Is expressed in several structures, including alimentary system; hindlimb mesenchyme; lower urinary tract; otic capsule; and skeleton. Orthologous to human NCMAP (non-compact myelin associated protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in placenta adult (RPKM 8.9), stomach adult (RPKM 7.0) and 13 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 D3; 4 67.47 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (135096887..135125551, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (135369576..135398240, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10266 Neighboring gene predicted gene 12984 Neighboring gene serine/arginine repetitive matrix 1 Neighboring gene STARR-positive B cell enhancer ABC_E6233 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:134982608-134982761 Neighboring gene regulator of calcineurin 3 Neighboring gene microRNA 700 Neighboring gene STARR-positive B cell enhancer ABC_E9603 Neighboring gene STARR-positive B cell enhancer ABC_E1286 Neighboring gene NIPA-like domain containing 3 Neighboring gene STARR-positive B cell enhancer mm9_chr4:135050361-135050662 Neighboring gene sperm tail PG rich repeat containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Analysis of peripheral nerve expression profiles identifies a novel myelin glycoprotein, MP11. Ryu EJ, et al. J Neurosci, 2008 Jul 23. PMID 18650334, Free PMC Article
    2. Placental PPARγ regulates spatiotemporally diverse genes and a unique metabolic network. Shalom-Barak T, et al. Dev Biol, 2012 Dec 1. PMID 22967998, Free PMC Article
    3. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables structural constituent of myelin sheath IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of myelin sheath ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in peripheral nervous system myelin formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peripheral nervous system myelin formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of myelination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of myelination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Schmidt-Lanterman incisure IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Schmidt-Lanterman incisure ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in paranode region of axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in paranode region of axon ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    noncompact myelin-associated protein
    Names
    myelin protein of 11 kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168498.1 → NP_001161970.1  noncompact myelin-associated protein isoform 1

      See identical proteins and their annotated locations for NP_001161970.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4 and 6 encode the same isoform (1).
      Source sequence(s)
      AK014757, AK039485, BB093741, BY023152
      Consensus CDS
      CCDS18784.1
      UniProtKB/Swiss-Prot
      Q99JS0
      Related
      ENSMUSP00000101483.2, ENSMUST00000105857.8

    2. NM_001168500.1 → NP_001161972.1  noncompact myelin-associated protein isoform 1

      See identical proteins and their annotated locations for NP_001161972.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4 and 6 encode the same isoform (1).
      Source sequence(s)
      AL627185
      Consensus CDS
      CCDS18784.1
      UniProtKB/Swiss-Prot
      Q99JS0
      Related
      ENSMUSP00000101485.2, ENSMUST00000105859.8

    3. NM_001243305.1 → NP_001230234.1  noncompact myelin-associated protein isoform 1

      See identical proteins and their annotated locations for NP_001230234.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4 and 6 encode the same isoform (1).
      Source sequence(s)
      AL627185
      Consensus CDS
      CCDS18784.1
      UniProtKB/Swiss-Prot
      Q99JS0
      Related
      ENSMUSP00000070780.9, ENSMUST00000064481.15

    4. NM_001243306.1 → NP_001230235.1  noncompact myelin-associated protein isoform 2

      See identical proteins and their annotated locations for NP_001230235.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, contains an alternate exon and uses an upstream, in-frame start codon, compared to variant 1. The encoded isoform (2) has a longer N-terminus compared to isoform 1.
      Source sequence(s)
      AL627185
      Consensus CDS
      CCDS57304.1
      UniProtKB/TrEMBL
      A2A992
      Related
      ENSMUSP00000101486.3, ENSMUST00000105860.9

    5. NM_145555.2 → NP_663530.1  noncompact myelin-associated protein isoform 1

      See identical proteins and their annotated locations for NP_663530.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1. Variants 1, 2, 3, 4 and 6 encode the same isoform.
      Source sequence(s)
      AK039485, AK167453, BB093741
      Consensus CDS
      CCDS18784.1
      UniProtKB/Swiss-Prot
      Q99JS0

    6. NM_181047.1 → NP_851390.1  noncompact myelin-associated protein isoform 1

      See identical proteins and their annotated locations for NP_851390.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4 and 6 encode the same isoform (1).
      Source sequence(s)
      AK014757, AK076488, BB093741, BY023152
      Consensus CDS
      CCDS18784.1
      UniProtKB/Swiss-Prot
      Q99JS0
      Related
      ENSMUSP00000101484.2, ENSMUST00000105858.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      135096887..135125551 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017320160.2 → XP_017175649.1  noncompact myelin-associated protein isoform X1

      UniProtKB/Swiss-Prot
      Q99JS0

    2. XM_030253469.2 → XP_030109329.1  noncompact myelin-associated protein isoform X1

      UniProtKB/Swiss-Prot
      Q99JS0
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99JS0.1 GenPept UniProtKB/Swiss-Prot:Q99JS0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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