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    Man1c1 mannosidase, alpha, class 1C, member 1 [ Mus musculus (house mouse) ]

    Gene ID: 230815, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Man1c1provided by MGI
    Official Full Name
    mannosidase, alpha, class 1C, member 1provided by MGI
    Primary source
    MGI:MGI:2446214
    See related
    Ensembl:ENSMUSG00000037306 AllianceGenome:MGI:2446214
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable calcium ion binding activity and mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. Predicted to be involved in N-glycan processing. Predicted to act upstream of or within mannose metabolic process and proteoglycan biosynthetic process. Predicted to be located in Golgi apparatus. Predicted to be active in Golgi membrane and endoplasmic reticulum. Is expressed in several structures, including cerebellum; genitourinary system; gut; hemolymphoid system gland; and liver. Orthologous to human MAN1C1 (mannosidase alpha class 1C member 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 8.3), cerebellum adult (RPKM 7.8) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 D3; 4 66.88 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (134289001..134432987, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (134561690..134704290, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr4:134091101-134091402 Neighboring gene mitochondrial fission regulator 1-like Neighboring gene selenoprotein N Neighboring gene STARR-seq mESC enhancer starr_11681 Neighboring gene microRNA 6403 Neighboring gene predicted gene, 42326 Neighboring gene STARR-seq mESC enhancer starr_11682 Neighboring gene STARR-seq mESC enhancer starr_11683 Neighboring gene STARR-positive B cell enhancer ABC_E9086 Neighboring gene STARR-positive B cell enhancer ABC_E10265 Neighboring gene low density lipoprotein receptor adaptor protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E3527 Neighboring gene STARR-seq mESC enhancer starr_11687 Neighboring gene STARR-seq mESC enhancer starr_11688 Neighboring gene macoilin 1 Neighboring gene STARR-positive B cell enhancer ABC_E2718 Neighboring gene STARR-positive B cell enhancer ABC_E4682

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Respiratory distress and neonatal lethality in mice lacking Golgi alpha1,2-mannosidase IB involved in N-glycan maturation. Tremblay LO, et al. J Biol Chem, 2007 Jan 26. PMID 17121831
    2. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within mannose metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mannose trimming involved in glycoprotein ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within proteoglycan biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    mannosyl-oligosaccharide 1,2-alpha-mannosidase IC
    NP_001413017.1
    NP_997120.1
    XP_036019960.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001426088.1 → NP_001413017.1  mannosyl-oligosaccharide 1,2-alpha-mannosidase IC isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL627122, AL669982

    2. NM_207237.4 → NP_997120.1  mannosyl-oligosaccharide 1,2-alpha-mannosidase IC isoform 1

      See identical proteins and their annotated locations for NP_997120.1

      Status: VALIDATED

      Source sequence(s)
      AL627122, AL669982
      Consensus CDS
      CCDS18776.1
      UniProtKB/TrEMBL
      Q3UN34, Q6NXK9
      Related
      ENSMUSP00000050979.7, ENSMUST00000054096.13
      Conserved Domains (1) summary
      pfam01532
      Location:176 → 612
      Glyco_hydro_47; Glycosyl hydrolase family 47

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      134289001..134432987 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164067.1 → XP_036019960.1  mannosyl-oligosaccharide 1,2-alpha-mannosidase IC isoform X1

      UniProtKB/TrEMBL
      Q3UN34
      Conserved Domains (1) summary
      pfam01532
      Location:176 → 656
      Glyco_hydro_47; Glycosyl hydrolase family 47
    Nucleotide Protein Strain
    Heading Accession and Version

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