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    Gnl2 guanine nucleotide binding protein nucleolar 2 [ Mus musculus (house mouse) ]

    Gene ID: 230737, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Gnl2provided by MGI
    Official Full Name
    guanine nucleotide binding protein nucleolar 2provided by MGI
    Primary source
    MGI:MGI:2385207
    See related
    Ensembl:ENSMUSG00000028869 AllianceGenome:MGI:2385207
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ngp-1; HUMAUANTIG
    Summary
    Predicted to enable GTP binding activity. Predicted to act upstream of or within ribosome biogenesis. Predicted to be located in nucleus. Predicted to be active in nucleolus. Is expressed in peripheral nervous system ganglion; renal cortex; thymus primordium; and vibrissa. Orthologous to human GNL2 (G protein nucleolar 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 19.5), CNS E18 (RPKM 17.9) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 D2.2; 4 57.97 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (124920866..124949175)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (125029989..125055382)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12930 Neighboring gene R-spondin 1 Neighboring gene predicted gene, 38472 Neighboring gene STARR-positive B cell enhancer ABC_E7987 Neighboring gene dynein, axonemal, light intermediate polypeptide 1 Neighboring gene STARR-positive B cell enhancer ABC_E6215 Neighboring gene Smad nuclear interacting protein 1 Neighboring gene splicing factor 3a, subunit 2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Transcription factor Foxp3 and its protein partners form a complex regulatory network. Rudra D, et al. Nat Immunol, 2012 Oct. PMID 22922362, Free PMC Article
    2. Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins. Lang B, et al. Nucleic Acids Res, 2021 Jul 9. PMID 34133714, Free PMC Article
    3. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article
    4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC7863

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    nucleolar GTP-binding protein 2
    Names
    guanine nucleotide binding protein-like 2 (nucleolar)
    testicular antigen

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145552.2 → NP_663527.2  nucleolar GTP-binding protein 2

      See identical proteins and their annotated locations for NP_663527.2

      Status: VALIDATED

      Source sequence(s)
      AK037796, AK077532, AV236719, BY140435
      Consensus CDS
      CCDS18634.1
      UniProtKB/Swiss-Prot
      B1ASC3, Q8BIF8, Q99LH1
      UniProtKB/TrEMBL
      Q3UJL0
      Related
      ENSMUSP00000030684.8, ENSMUST00000030684.8
      Conserved Domains (2) summary
      cd01858
      Location:209 → 365
      NGP_1; A novel nucleolar GTP-binding protein, circularly permuted subfamily of the Ras GTPases
      pfam08153
      Location:43 → 174
      NGP1NT; NGP1NT (NUC091) domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      124920866..124949175
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164045.1 → XP_036019938.1  nucleolar GTP-binding protein 2 isoform X1

      UniProtKB/Swiss-Prot
      B1ASC3, Q8BIF8, Q99LH1
      UniProtKB/TrEMBL
      Q3UJL0
      Conserved Domains (2) summary
      cd01858
      Location:209 → 365
      NGP_1; A novel nucleolar GTP-binding protein, circularly permuted subfamily of the Ras GTPases
      pfam08153
      Location:43 → 174
      NGP1NT; NGP1NT (NUC091) domain

    2. XM_006503029.4 → XP_006503092.1  nucleolar GTP-binding protein 2 isoform X2

      Conserved Domains (2) summary
      cd01858
      Location:50 → 206
      NGP_1; A novel nucleolar GTP-binding protein, circularly permuted subfamily of the Ras GTPases
      COG1160
      Location:157 → 262
      Der; Predicted GTPases [General function prediction only]

    3. XM_030253448.2 → XP_030109308.1  nucleolar GTP-binding protein 2 isoform X3

      Conserved Domains (2) summary
      cd01858
      Location:2 → 154
      NGP_1; A novel nucleolar GTP-binding protein, circularly permuted subfamily of the Ras GTPases
      COG1160
      Location:105 → 210
      Der; Predicted GTPases [General function prediction only]

    4. XM_017320153.2 → XP_017175642.1  nucleolar GTP-binding protein 2 isoform X3

      Conserved Domains (2) summary
      cd01858
      Location:2 → 154
      NGP_1; A novel nucleolar GTP-binding protein, circularly permuted subfamily of the Ras GTPases
      COG1160
      Location:105 → 210
      Der; Predicted GTPases [General function prediction only]

    5. XM_030253450.2 → XP_030109310.1  nucleolar GTP-binding protein 2 isoform X4

      Conserved Domains (2) summary
      cd01858
      Location:1 → 136
      NGP_1; A novel nucleolar GTP-binding protein, circularly permuted subfamily of the Ras GTPases
      COG1160
      Location:87 → 192
      Der; Predicted GTPases [General function prediction only]

    6. XM_030253449.2 → XP_030109309.1  nucleolar GTP-binding protein 2 isoform X3

      Conserved Domains (2) summary
      cd01858
      Location:2 → 154
      NGP_1; A novel nucleolar GTP-binding protein, circularly permuted subfamily of the Ras GTPases
      COG1160
      Location:105 → 210
      Der; Predicted GTPases [General function prediction only]

    7. XM_011240502.3 → XP_011238804.1  nucleolar GTP-binding protein 2 isoform X4

      Conserved Domains (2) summary
      cd01858
      Location:1 → 136
      NGP_1; A novel nucleolar GTP-binding protein, circularly permuted subfamily of the Ras GTPases
      COG1160
      Location:87 → 192
      Der; Predicted GTPases [General function prediction only]

    8. XM_030253451.2 → XP_030109311.1  nucleolar GTP-binding protein 2 isoform X5

      Conserved Domains (1) summary
      COG1161
      Location:1 → 113
      RbgA; Ribosome biogenesis GTPase A [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99LH1.2 GenPept UniProtKB/Swiss-Prot:Q99LH1

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