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    Epha10 Eph receptor A10 [ Mus musculus (house mouse) ]

    Gene ID: 230735, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Epha10provided by MGI
    Official Full Name
    Eph receptor A10provided by MGI
    Primary source
    MGI:MGI:3586824
    See related
    Ensembl:ENSMUSG00000028876 AllianceGenome:MGI:3586824
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A330090H18
    Summary
    Predicted to enable transmembrane-ephrin receptor activity. Predicted to be involved in axon guidance; positive regulation of kinase activity; and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to act upstream of or within phosphorylation. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be part of receptor complex. Predicted to be active in neuron projection. Predicted to be integral component of plasma membrane. Is expressed in central nervous system and metanephros. Orthologous to human EPHA10 (EPH receptor A10). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in cortex adult (RPKM 7.2), frontal lobe adult (RPKM 6.4) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 D2.2; 4 57.92 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (124775408..124811594)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (124881530..124917801)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene metal response element binding transcription factor 1 Neighboring gene RIKEN cDNA 1110065P20 gene Neighboring gene yrdC domain containing (E.coli) Neighboring gene mannosidase, endo-alpha-like Neighboring gene RIKEN cDNA 1700125G02 gene Neighboring gene cell division cycle associated 8 Neighboring gene STARR-positive B cell enhancer ABC_E424 Neighboring gene STARR-positive B cell enhancer ABC_E4665 Neighboring gene AFG2 interacting ribosome maturation factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Increased EphA/ephrinA expression in hippocampus of pilocarpine treated mouse. Xia Y, et al. Epilepsy Res, 2013 Jul. PMID 23352741
    2. Embryonic expression of EphA receptor genes in mice supports their candidacy for involvement in cleft lip and palate. Agrawal P, et al. Dev Dyn, 2014 Nov. PMID 25073978, Free PMC Article
    3. EphA receptors inhibit anti-CD3-induced apoptosis in thymocytes. Freywald A, et al. J Immunol, 2006 Apr 1. PMID 16547242
    4. Characterization of a novel Eph receptor tyrosine kinase, EphA10, expressed in testis. Aasheim HC, et al. Biochim Biophys Acta, 2005 May 25. PMID 15777695
    5. Expression and requirement of T-box transcription factors Tbx2 and Tbx3 during secondary palate development in the mouse. Zirzow S, et al. Dev Biol, 2009 Dec 15. PMID 19769959

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ephrin A10 is significantly increased in hippocampus following epileptogenesis.
      Title: Increased EphA/ephrinA expression in hippocampus of pilocarpine treated mouse.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (3) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ephrin receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane receptor protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane-ephrin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane-ephrin receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ephrin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ephrin type-A receptor 10
    NP_001243361.1
    NP_808339.2
    XP_006503090.1
    XP_006503091.1
    XP_017175641.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256432.2 → NP_001243361.1  ephrin type-A receptor 10 isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL606933
      UniProtKB/Swiss-Prot
      A2A7J5, Q3UPV5, Q8BYG9
      Conserved Domains (7) summary
      cd09549
      Location:928 → 997
      SAM_EPH-A10; SAM domain of EPH-A10 subfamily of tyrosine kinase receptors
      smart00454
      Location:931 → 996
      SAM; Sterile alpha motif
      cd00063
      Location:451 → 551
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07714
      Location:644 → 899
      Pkinase_Tyr; Protein tyrosine kinase
      pfam14575
      Location:573 → 639
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
      cl02704
      Location:35 → 210
      EphR_LBD; Ligand Binding Domain of Ephrin Receptors
      cl21453
      Location:638 → 902
      PKc_like; Protein Kinases, catalytic domain

    2. NM_177671.6 → NP_808339.2  ephrin type-A receptor 10 isoform 2 precursor

      See identical proteins and their annotated locations for NP_808339.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks several exons and its transcription extends past a splice site that is used in variant 1, resulting in a novel 3' coding region and 3' UTR compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK143168
      Consensus CDS
      CCDS18630.1
      UniProtKB/Swiss-Prot
      Q8BYG9
      Related
      ENSMUSP00000050810.6, ENSMUST00000059343.7
      Conserved Domains (1) summary
      cl02704
      Location:35 → 210
      EphR_LBD; Ligand Binding Domain of Ephrin Receptors

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      124775408..124811594
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006503027.3 → XP_006503090.1  ephrin type-A receptor 10 isoform X2

      Conserved Domains (4) summary
      cd00063
      Location:465 → 551
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:339 → 431
      fn3; Fibronectin type III domain
      pfam14575
      Location:573 → 639
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
      cl02704
      Location:35 → 210
      EphR_LBD; Ligand Binding Domain of Ephrin Receptors

    2. XM_006503028.5 → XP_006503091.1  ephrin type-A receptor 10 isoform X3

      Conserved Domains (3) summary
      cd00063
      Location:465 → 551
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:339 → 431
      fn3; Fibronectin type III domain
      cl02704
      Location:35 → 210
      EphR_LBD; Ligand Binding Domain of Ephrin Receptors

    3. XM_017320152.3 → XP_017175641.1  ephrin type-A receptor 10 isoform X1

      UniProtKB/TrEMBL
      F6WVB0
      Related
      ENSMUSP00000118801.2, ENSMUST00000149146.2
      Conserved Domains (5) summary
      cd09549
      Location:758 → 827
      SAM_EPH-A10; SAM domain of EPH-A10 subfamily of tyrosine kinase receptors
      cd00063
      Location:281 → 381
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam14575
      Location:403 → 469
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
      cl02704
      Location:1 → 40
      EphR_LBD; Ligand Binding Domain of Ephrin Receptors
      cl21453
      Location:468 → 732
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. XR_004941869.1 RNA Sequence

    2. XR_004941871.1 RNA Sequence

    3. XR_004941870.1 RNA Sequence

    4. XR_004941872.1 RNA Sequence

    5. XR_376312.3 RNA Sequence

    6. XR_003954922.2 RNA Sequence

    7. XR_003954923.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BYG9.2 GenPept UniProtKB/Swiss-Prot:Q8BYG9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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