Ipo13 importin 13 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ipo13provided by MGI
Official Full Name: importin 13provided by MGI
Primary source: MGI:MGI:2385205
See related: Ensembl:ENSMUSG00000033365 AllianceGenome:MGI:2385205
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Imp13; Kap13; Ranbp13
Summary: Predicted to enable glucocorticoid receptor binding activity. Predicted to be involved in protein import into nucleus. Predicted to act upstream of or within protein transport. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Is expressed in several structures, including central nervous system; olfactory epithelium; skin; submandibular gland primordium; and thymus primordium. Orthologous to human IPO13 (importin 13). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 70.7), ovary adult (RPKM 30.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D1; 4 53.76 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (117751689..117772419, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (117893268..117915222, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nuclear Transporter IPO13 Is Central to Efficient Neuronal Differentiation.
Title: Nuclear Transporter IPO13 Is Central to Efficient Neuronal Differentiation.
Nuclear transporter Importin-13 plays a key role in the oxidative stress transcriptional response.
Title: Nuclear transporter Importin-13 plays a key role in the oxidative stress transcriptional response.
Importin 13 promotes NSCLC progression by mediating RFPL3 nuclear translocation and hTERT expression upregulation.
Title: Importin 13 promotes NSCLC progression by mediating RFPL3 nuclear translocation and hTERT expression upregulation.
The nuclear transporter importin 13 is critical for cell survival during embryonic stem cell differentiation.
Title: The nuclear transporter importin 13 is critical for cell survival during embryonic stem cell differentiation.
Interactome of the inhibitory isoform of the nuclear transporter Importin 13 has been reported.
Title: Interactome of the inhibitory isoform of the nuclear transporter Importin 13.
Imp13 contributes to the neural cell-specific cargo trafficking and potentially to other functions during brain development.
Title: Expression and subcellular distribution of imp13 are regulated in brain development.
IPO13 has a stage-specific role in nuclear-cytoplasmic translocation of cargoes that accompanies meiotic differentiation of the mouse germ cells
Title: Stage-specific Importin13 activity influences meiosis of germ cells in the mouse.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH141226 (e-PCR)
- UniSTS:223222

NoName (e-PCR)
- UniSTS:235002

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables nuclear glucocorticoid receptor binding	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in protein import into nucleus	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein import into nucleus	ISO Inferred from Sequence Orthology more info	PubMed
involved_in protein import into nucleus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: importin-13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001419414.1 → NP_001406343.1 importin-13 isoform 2

Status: VALIDATED

Source sequence(s)

AL627128
NM_146152.3 → NP_666264.1 importin-13 isoform 1

See identical proteins and their annotated locations for NP_666264.1

Status: VALIDATED

Source sequence(s)

AK052257

Consensus CDS

CCDS18542.1

UniProtKB/Swiss-Prot

Q6ZQ60, Q8K0C1

UniProtKB/TrEMBL

Q3UDQ3

Related

ENSMUSP00000035989.6, ENSMUST00000036156.6

Conserved Domains (3) summary

smart00913
Location:45 → 109

IBN_N; Importin-beta N-terminal domain

COG5101
Location:20 → 650

CRM1; Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]

pfam08389
Location:116 → 263

Xpo1; Exportin 1-like protein

RNA

NR_185081.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL627128

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

117751689..117772419 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017320147.3 → XP_017175636.1 importin-13 isoform X1

Conserved Domains (5) summary

smart00913
Location:45 → 109

IBN_N; Importin-beta N-terminal domain

COG5101
Location:20 → 650

CRM1; Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]

pfam08389
Location:116 → 263

Xpo1; Exportin 1-like protein

pfam18773
Location:402 → 441

Importin_rep; Importin 13 repeat

pfam18786
Location:631 → 672

Importin_rep_2; Importin 13 repeat