Glis1 GLIS family zinc finger 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Glis1provided by MGI
Official Full Name: GLIS family zinc finger 1provided by MGI
Primary source: MGI:MGI:2386723
See related: Ensembl:ENSMUSG00000034762 AllianceGenome:MGI:2386723
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gli5; Gli6; GliH1
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including fat cell differentiation; osteoblast differentiation; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within negative regulation of transcription by RNA polymerase II and positive regulation of transcription, DNA-templated. Located in nucleus. Is expressed in several structures, including alimentary system; embryo mesenchyme; genitourinary system; sensory organ; and skin. Orthologous to human GLIS1 (GLIS family zinc finger 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in kidney adult (RPKM 4.5), limb E14.5 (RPKM 2.5) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 C7; 4 50.18 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (107283840..107492258)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (107426636..107635061)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GLIS1 intervention enhances anti-PD1 therapy for hepatocellular carcinoma by targeting SGK1-STAT3-PD1 pathway.
Title: GLIS1 intervention enhances anti-PD1 therapy for hepatocellular carcinoma by targeting SGK1-STAT3-PD1 pathway.
GLIS1 regulates trabecular meshwork function and intraocular pressure and is associated with glaucoma in humans.
Title: GLIS1 regulates trabecular meshwork function and intraocular pressure and is associated with glaucoma in humans.
RNF220-mediated ubiquitination promotes aggresomal accumulation and autophagic degradation of cytoplasmic Gli via HDAC6.
Title: RNF220-mediated ubiquitination promotes aggresomal accumulation and autophagic degradation of cytoplasmic Gli via HDAC6.
Glis1 facilitates induction of pluripotency via an epigenome-metabolome-epigenome signalling cascade.
Title: Glis1 facilitates induction of pluripotency via an epigenome-metabolome-epigenome signalling cascade.
Hedgehog-FGF signaling axis patterns anterior mesoderm during gastrulation.
Title: Hedgehog-FGF signaling axis patterns anterior mesoderm during gastrulation.
Glis1 is expressed during embryonic development predominantly in nuclei of endothelial and interstitial cells of mitral valves in mouse.
Title: Genome-Wide Association Study-Driven Gene-Set Analyses, Genetic, and Functional Follow-Up Suggest GLIS1 as a Susceptibility Gene for Mitral Valve Prolapse.
Identification of aryl hydrocarbon receptor and Glis family zinc finger 1 as mesenchymal key transcription factors controlled by dynamic cell type-specific super-enhancers that become repressed during differentiation toward adipocytes and osteoblasts.
Title: Temporal enhancer profiling of parallel lineages identifies AHR and GLIS1 as regulators of mesenchymal multipotency.
Lsd1 regulates skeletal muscle regeneration and directs the fate of satellite cells into myocytes while preventing brown adipocyte differentiation of satellite cells via repressing expression of the novel pro-adipogenic transcription factor Glis1.
Title: Lsd1 regulates skeletal muscle regeneration and directs the fate of satellite cells.
results therefore show that Glis1 effectively promotes the direct reprogramming of somatic cells during iPSC generation.
Title: Direct reprogramming of somatic cells is promoted by maternal transcription factor Glis1.
GliH1 has homology to the Gli zinc finger domain but is not required for mouse development
Title: A novel gene, GliH1, with homology to the Gli zinc finger domain not required for mouse development.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Glis1 (e-PCR), detects polymorphism
- UniSTS:547695

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in osteoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: zinc finger protein GLIS1

Names: GLI-Kruppel family member GLI6; GLI-similar 1; Glis1 Kruppel-like zinc finger protein; gli homologous protein 1; zinc finger transcription factor Gli5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_147221.2 → NP_671754.2 zinc finger protein GLIS1

See identical proteins and their annotated locations for NP_671754.2

Status: VALIDATED

Source sequence(s)

AK145342, AL626784, AL627259, BC066157

Consensus CDS

CCDS38831.1

UniProtKB/Swiss-Prot

Q6NZF6, Q8K1M4, Q8R4Z3

UniProtKB/TrEMBL

H6WAT1

Related

ENSMUSP00000035650.3, ENSMUST00000046005.9

Conserved Domains (2) summary

COG5048
Location:431 → 510

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:435 → 457

ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

107283840..107492258

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006502972.4 → XP_006503035.1 zinc finger protein GLIS1 isoform X2

UniProtKB/TrEMBL

H6WAT1

Conserved Domains (2) summary

COG5048
Location:446 → 525

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:450 → 472

ZF_C2H2; C2H2 Zn finger [structural motif]
XM_006502973.5 → XP_006503036.1 zinc finger protein GLIS1 isoform X3

See identical proteins and their annotated locations for XP_006503036.1

UniProtKB/Swiss-Prot

Q6NZF6, Q8K1M4, Q8R4Z3

UniProtKB/TrEMBL

H6WAT1

Conserved Domains (2) summary

COG5048
Location:431 → 510

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:435 → 457

ZF_C2H2; C2H2 Zn finger [structural motif]
XM_030253436.2 → XP_030109296.1 zinc finger protein GLIS1 isoform X4

UniProtKB/TrEMBL

H6WAT1

Conserved Domains (2) summary

COG5048
Location:431 → 525

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:435 → 457

ZF_C2H2; C2H2 Zn finger [structural motif]
XM_006502974.5 → XP_006503037.1 zinc finger protein GLIS1 isoform X3

See identical proteins and their annotated locations for XP_006503037.1

UniProtKB/Swiss-Prot

Q6NZF6, Q8K1M4, Q8R4Z3

UniProtKB/TrEMBL

H6WAT1

Conserved Domains (2) summary

COG5048
Location:431 → 510

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:435 → 457

ZF_C2H2; C2H2 Zn finger [structural motif]
XM_006502975.2 → XP_006503038.1 zinc finger protein GLIS1 isoform X3

See identical proteins and their annotated locations for XP_006503038.1

UniProtKB/Swiss-Prot

Q6NZF6, Q8K1M4, Q8R4Z3

UniProtKB/TrEMBL

H6WAT1

Conserved Domains (2) summary

COG5048
Location:431 → 510

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:435 → 457

ZF_C2H2; C2H2 Zn finger [structural motif]
XM_036164022.1 → XP_036019915.1 zinc finger protein GLIS1 isoform X1

UniProtKB/TrEMBL

H6WAT1

Conserved Domains (1) summary

sd00017
Location:372 → 391

ZF_C2H2; C2H2 Zn finger [structural motif]