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    Pars2 prolyl-tRNA synthetase (mitochondrial)(putative) [ Mus musculus (house mouse) ]

    Gene ID: 230577, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Pars2provided by MGI
    Official Full Name
    prolyl-tRNA synthetase (mitochondrial)(putative)provided by MGI
    Primary source
    MGI:MGI:2386296
    See related
    Ensembl:ENSMUSG00000043572 AllianceGenome:MGI:2386296
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable proline-tRNA ligase activity. Predicted to be involved in prolyl-tRNA aminoacylation. Predicted to act upstream of or within translation. Located in mitochondrion. Is expressed in adrenal gland and gland. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 75. Orthologous to human PARS2 (prolyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thymus adult (RPKM 2.6), ovary adult (RPKM 2.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 C7; 4 49.67 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (106508266..106512479)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (106651069..106655282)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene ciliary microtubule associated protein 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:106287642-106287893 Neighboring gene STARR-positive B cell enhancer ABC_E10244 Neighboring gene tetratricopeptide repeat domain 22 Neighboring gene STARR-positive B cell enhancer ABC_E2700 Neighboring gene tetratricopeptide repeat domain 4 Neighboring gene STARR-positive B cell enhancer ABC_E6195 Neighboring gene maestro heat-like repeat family member 7 Neighboring gene family with sequence simliarity 151, member A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Carninci P, et al. Genome Res, 2003 Jun. PMID 12819125, Free PMC Article
    2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    3. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC47008

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables proline-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in prolyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA aminoacylation for protein translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    probable proline--tRNA ligase, mitochondrial
    Names
    class II tRNA synthetase
    proRS
    probable prolyl-tRNA synthetase, mitochondrial
    proline--tRNA ligase
    NP_001077356.1
    NP_001272712.1
    NP_001272713.1
    NP_758476.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083887.2 → NP_001077356.1  probable proline--tRNA ligase, mitochondrial isoform 2

      See identical proteins and their annotated locations for NP_001077356.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. Variants 2 and 3 encode the same isoform (2).
      Source sequence(s)
      AL929585
      Consensus CDS
      CCDS38828.1
      UniProtKB/TrEMBL
      A8Y5T6, Q3U4M2
      Related
      ENSMUSP00000102393.2, ENSMUST00000106781.2
      Conserved Domains (3) summary
      PRK09194
      Location:78 → 506
      PRK09194; prolyl-tRNA synthetase; Provisional
      cd00779
      Location:101 → 390
      ProRS_core_prok; Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of ...
      cd00861
      Location:405 → 506
      ProRS_anticodon_short; ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, ...

    2. NM_001285783.1 → NP_001272712.1  probable proline--tRNA ligase, mitochondrial isoform 2

      See identical proteins and their annotated locations for NP_001272712.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript. Variants 2 and 3 encode the same isoform (2).
      Source sequence(s)
      AL929585, BB652093
      Consensus CDS
      CCDS38828.1
      UniProtKB/TrEMBL
      A8Y5T6, Q3U4M2
      Conserved Domains (3) summary
      PRK09194
      Location:78 → 506
      PRK09194; prolyl-tRNA synthetase; Provisional
      cd00779
      Location:101 → 390
      ProRS_core_prok; Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of ...
      cd00861
      Location:405 → 506
      ProRS_anticodon_short; ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, ...

    3. NM_001285784.1 → NP_001272713.1  probable proline--tRNA ligase, mitochondrial isoform 1

      See identical proteins and their annotated locations for NP_001272713.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and the 5' coding region and initiates translation at an alternate start codon, compared to variant 3. Variants 1 and 4 encode the same isoform (1), which is shorter at the N-terminus compared to isoform 2.
      Source sequence(s)
      AL929585, BB842735
      Consensus CDS
      CCDS18423.1
      UniProtKB/Swiss-Prot
      A2AVQ8, Q8CFI5, Q8R0C4
      UniProtKB/TrEMBL
      Q3U4M2
      Conserved Domains (3) summary
      PRK09194
      Location:42 → 470
      PRK09194; prolyl-tRNA synthetase; Provisional
      cd00779
      Location:65 → 354
      ProRS_core_prok; Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of ...
      cd00861
      Location:369 → 470
      ProRS_anticodon_short; ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, ...

    4. NM_172272.2 → NP_758476.2  probable proline--tRNA ligase, mitochondrial isoform 1

      See identical proteins and their annotated locations for NP_758476.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR and the 5' coding region and initiates translation at an alternate start codon, compared to variant 3. Variants 1 and 4 encode the same isoform (1), which is shorter at the N-terminus compared to isoform 2.
      Source sequence(s)
      AL929585, BY768753
      Consensus CDS
      CCDS18423.1
      UniProtKB/Swiss-Prot
      A2AVQ8, Q8CFI5, Q8R0C4
      UniProtKB/TrEMBL
      Q3U4M2
      Related
      ENSMUSP00000053160.8, ENSMUST00000058905.8
      Conserved Domains (3) summary
      PRK09194
      Location:42 → 470
      PRK09194; prolyl-tRNA synthetase; Provisional
      cd00779
      Location:65 → 354
      ProRS_core_prok; Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of ...
      cd00861
      Location:369 → 470
      ProRS_anticodon_short; ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      106508266..106512479
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CFI5.2 GenPept UniProtKB/Swiss-Prot:Q8CFI5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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