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    Nol6 nucleolar protein family 6 (RNA-associated) [ Mus musculus (house mouse) ]

    Gene ID: 230082, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Nol6provided by MGI
    Official Full Name
    nucleolar protein family 6 (RNA-associated)provided by MGI
    Primary source
    MGI:MGI:2140151
    See related
    Ensembl:ENSMUSG00000028430 AllianceGenome:MGI:2140151
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nrap
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in rRNA processing and tRNA export from nucleus. Located in condensed nuclear chromosome and nucleolus. Is expressed in several structures, including gut; liver; lung; spleen; and testis. Orthologous to human NOL6 (nucleolar protein 6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 36.7), ovary adult (RPKM 27.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 A5; 4 20.98 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (41114427..41124450, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (41114427..41124339, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 25637 Neighboring gene STARR-seq mESC enhancer starr_10018 Neighboring gene aquaporin 3 Neighboring gene STARR-positive B cell enhancer ABC_E150 Neighboring gene STARR-positive B cell enhancer ABC_E6162 Neighboring gene ubiquitin-conjugating enzyme E2R 2 Neighboring gene STARR-seq mESC enhancer starr_10025 Neighboring gene ubiquitin-associated protein 2 Neighboring gene predicted gene, 22888

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Expression and alternative splicing of N-RAP during mouse skeletal muscle development. Lu S, et al. Cell Motil Cytoskeleton, 2008 Dec. PMID 18792955, Free PMC Article
    2. Role of nonmuscle myosin IIB and N-RAP in cell spreading and myofibril assembly in primary mouse cardiomyocytes. Lu S, et al. Cell Motil Cytoskeleton, 2008 Sep. PMID 18615632, Free PMC Article
    3. Isolation and characterization of a new nucleolar protein, Nrap, that is conserved from yeast to humans. Utama B, et al. Genes Cells, 2002 Feb. PMID 11895476
    4. New N-RAP-binding partners alpha-actinin, filamin and Krp1 detected by yeast two-hybrid screening: implications for myofibril assembly. Lu S, et al. J Cell Sci, 2003 Jun 1. PMID 12692149
    5. Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia. Grebien F, et al. Nat Chem Biol, 2015 Aug. PMID 26167872, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-RAP-s is the predominant spliced form of N-RAP present throughout skeletal muscle development.
      Title: Expression and alternative splicing of N-RAP during mouse skeletal muscle development.
    2. The results show that NMHC IIB knockdown led to decreased N-RAP levels through proteasome-mediated degradation.
      Title: Role of nonmuscle myosin IIB and N-RAP in cell spreading and myofibril assembly in primary mouse cardiomyocytes.
    3. three new N-RAP binding partners: alpha-actinin, filamin-2, and Krp1 (also called sarcosin) in myofibril assembly
      Title: New N-RAP-binding partners alpha-actinin, filamin and Krp1 detected by yeast two-hybrid screening: implications for myofibril assembly.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in rRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosomal small subunit biogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of CURI complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of UTP-C complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in condensed nuclear chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of small-subunit processome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of small-subunit processome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    nucleolar protein 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_139236.4 → NP_631982.2  nucleolar protein 6

      See identical proteins and their annotated locations for NP_631982.2

      Status: VALIDATED

      Source sequence(s)
      AL954379
      Consensus CDS
      CCDS38715.1
      UniProtKB/Swiss-Prot
      Q3TL75, Q3U1P8, Q6PAN8, Q8C6V4, Q8R5K3, Q8R5K4, Q8VCG0, Q8WTY7
      Related
      ENSMUSP00000030138.9, ENSMUST00000030138.9
      Conserved Domains (1) summary
      pfam03813
      Location:174 → 1144
      Nrap; Nrap protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      41114427..41124450 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_004941860.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_139237.1: Suppressed sequence

      Description
      NM_139237.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R5K4.2 GenPept UniProtKB/Swiss-Prot:Q8R5K4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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