U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Rap1gds1 RAP1, GTP-GDP dissociation stimulator 1 [ Mus musculus (house mouse) ]

    Gene ID: 229877, updated on 3-Apr-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Rap1gds1provided by MGI
    Official Full Name
    RAP1, GTP-GDP dissociation stimulator 1provided by MGI
    Primary source
    MGI:MGI:2385189
    See related
    Ensembl:ENSMUSG00000028149 AllianceGenome:MGI:2385189
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GDS1
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in negative regulation of endoplasmic reticulum calcium ion concentration; positive regulation of GTPase activity; and positive regulation of mitochondrial calcium ion concentration. Predicted to be located in endoplasmic reticulum and mitochondrion. Predicted to be active in cytosol. Is expressed in several structures, including central nervous system; dorsal root ganglion; glans of male genital tubercle; liver; and retina nuclear layer. Orthologous to human RAP1GDS1 (Rap1 GTPase-GDP dissociation stimulator 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in frontal lobe adult (RPKM 49.1), cortex adult (RPKM 47.6) and 27 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    3 H1; 3 64.52 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (138631662..138781163, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (138925897..139075228, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930425O10 gene Neighboring gene STARR-seq mESC enhancer starr_09115 Neighboring gene STARR-seq mESC enhancer starr_09116 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:138406051-138406234 Neighboring gene STARR-seq mESC enhancer starr_09117 Neighboring gene tetraspanin 5 Neighboring gene STARR-positive B cell enhancer ABC_E11223 Neighboring gene STARR-positive B cell enhancer mm9_chr3:138527106-138527407 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:138539885-138540140 Neighboring gene STARR-seq mESC enhancer starr_09124 Neighboring gene predicted gene, 54195 Neighboring gene synaptic nuclear envelope 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_09125 Neighboring gene STARR-positive B cell enhancer ABC_E6140 Neighboring gene STARR-seq mESC enhancer starr_09128 Neighboring gene STARR-positive B cell enhancer ABC_E7946 Neighboring gene predicted gene 4862 Neighboring gene STARR-positive B cell enhancer ABC_E3476 Neighboring gene sperm tail PG rich repeat containing 2 Neighboring gene predicted gene, 24260

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Vimar/RAP1GDS1 promotes acceleration of brain aging after flies and mice reach middle age.
      Title: Vimar/RAP1GDS1 promotes acceleration of brain aging after flies and mice reach middle age.
    2. Apoe(-/-) SmgGDS(+/-) mice showed significantly higher levels of oxidative stress, matrix metalloproteinases, and inflammatory cell migration in the ascending aorta compared with Apoe(-/-) mice. local delivery of the SmgGDS gene construct reversed the dilation of the ascending aorta in Apoe(-/-) SmgGDS(+/-) mice.
      Title: Small GTP-Binding Protein GDP Dissociation Stimulator Prevents Thoracic Aortic Aneurysm Formation and Rupture by Phenotypic Preservation of Aortic Smooth Muscle Cells.
    3. Simulated microgravity activates Cdc42 via Rap1GDS1 to promote vascular branch morphogenesis.
      Title: Microgravity simulation activates Cdc42 via Rap1GDS1 to promote vascular branch morphogenesis during vasculogenesis.
    4. results indicate that statins selectively up-regulate SmgGDS in endothelial cells, for which the beta1-integrin/Akt1 pathway may be involved, demonstrating the novel aspects of the pleiotropic effects of statins
      Title: Statins up-regulate SmgGDS through β1-integrin/Akt1 pathway in endothelial cells.
    5. These results indicate that statins exert their pleiotropic effects through SmgGDS upregulation with a resultant Rac1 degradation and reduced oxidative stress in animals and humans.
      Title: Statins exert the pleiotropic effects through small GTP-binding protein dissociation stimulator upregulation with a resultant Rac1 degradation.
    Submit: New GeneRIF Correction

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1)  1 citation
    • Endonuclease-mediated (3) 

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC18981

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase regulator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in CAAX-box protein maturation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within angiotensin-activated signaling pathway involved in heart process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cardiac muscle hypertrophy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cytokine production involved in inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in myosin filament assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of GTPase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of endoplasmic reticulum calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of mitochondrial calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of ERK5 cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of matrix metallopeptidase secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to statin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vascular associated smooth muscle contraction ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    rap1 GTPase-GDP dissociation stimulator 1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040690.3 → NP_001035780.1  rap1 GTPase-GDP dissociation stimulator 1 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC110574, AC113307, AC119881
      Consensus CDS
      CCDS51083.1
      UniProtKB/Swiss-Prot
      E9Q6Q4, E9Q912, I6L967, Q3TA69, Q3TLU4, Q3TPS9, Q3TU36
      UniProtKB/TrEMBL
      A0A0G2JGC8
      Related
      ENSMUSP00000096173.3, ENSMUST00000098574.9
      Conserved Domains (4) summary
      smart00185
      Location:346 → 389
      ARM; Armadillo/beta-catenin-like repeats
      PLN03200
      Location:42 → 264
      PLN03200; cellulose synthase-interactive protein; Provisional
      sd00043
      Location:91 → 116
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:86 → 117
      Arm; Armadillo/beta-catenin-like repeat

    2. NM_001286759.2 → NP_001273688.1  rap1 GTPase-GDP dissociation stimulator 1 isoform c

      See identical proteins and their annotated locations for NP_001273688.1

      Status: VALIDATED

      Source sequence(s)
      AC110574, AC113307, AC119881
      Consensus CDS
      CCDS80033.1
      UniProtKB/TrEMBL
      A0A0G2JGC8
      Related
      ENSMUSP00000143181.2, ENSMUST00000196280.5
      Conserved Domains (2) summary
      cd00020
      Location:317 → 430
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      sd00043
      Location:91 → 116
      ARM; armadillo repeat [structural motif]

    3. NM_001356388.2 → NP_001343317.1  rap1 GTPase-GDP dissociation stimulator 1 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC110574, AC113307, AC119881
      UniProtKB/TrEMBL
      A0A0G2JGC8
      Conserved Domains (3) summary
      pfam00514
      Location:86 → 117
      Arm; Armadillo/beta-catenin-like repeat
      sd00043
      Location:44 → 71
      ARM; armadillo repeat [structural motif]
      cl26969
      Location:177 → 342
      Vitellogenin_N; Lipoprotein amino terminal region

    4. NM_001411343.1 → NP_001398272.1  rap1 GTPase-GDP dissociation stimulator 1 isoform e

      Status: VALIDATED

      Source sequence(s)
      AC110574, AC113307, AC119881

    5. NM_001411344.1 → NP_001398273.1  rap1 GTPase-GDP dissociation stimulator 1 isoform f

      Status: VALIDATED

      Source sequence(s)
      AC110574, AC113307, AC119881

    6. NM_001411345.1 → NP_001398274.1  rap1 GTPase-GDP dissociation stimulator 1 isoform g

      Status: VALIDATED

      Source sequence(s)
      AC110574, AC113307, AC119881

    7. NM_001411346.1 → NP_001398275.1  rap1 GTPase-GDP dissociation stimulator 1 isoform h

      Status: VALIDATED

      Source sequence(s)
      AC110574, AC113307, AC119881

    8. NM_001411347.1 → NP_001398276.1  rap1 GTPase-GDP dissociation stimulator 1 isoform i

      Status: VALIDATED

      Source sequence(s)
      AC110574, AC113307, AC119881

    9. NM_001411348.1 → NP_001398277.1  rap1 GTPase-GDP dissociation stimulator 1 isoform j

      Status: VALIDATED

      Source sequence(s)
      AC110574, AC113307, AC119881

    10. NM_001411349.1 → NP_001398278.1  rap1 GTPase-GDP dissociation stimulator 1 isoform k

      Status: VALIDATED

      Source sequence(s)
      AC110574, AC113307, AC119881

    11. NM_001411350.1 → NP_001398279.1  rap1 GTPase-GDP dissociation stimulator 1 isoform l

      Status: VALIDATED

      Source sequence(s)
      AC110574, AC113307, AC119881

    12. NM_145544.4 → NP_663519.2  rap1 GTPase-GDP dissociation stimulator 1 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC110574, AC113307, AC119881
      Consensus CDS
      CCDS51082.1
      UniProtKB/TrEMBL
      A0A0G2JGC8
      Related
      ENSMUSP00000029796.7, ENSMUST00000029796.11
      Conserved Domains (2) summary
      cd00020
      Location:268 → 381
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      sd00043
      Location:44 → 71
      ARM; armadillo repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      138631662..138781163 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252602.2 → XP_030108462.1  rap1 GTPase-GDP dissociation stimulator 1 isoform X1

      Conserved Domains (3) summary
      smart00185
      Location:168 → 211
      ARM; Armadillo/beta-catenin-like repeats
      sd00043
      Location:173 → 212
      ARM; armadillo repeat [structural motif]
      cl26969
      Location:48 → 213
      Vitellogenin_N; Lipoprotein amino terminal region

    2. XM_036163086.1 → XP_036018979.1  rap1 GTPase-GDP dissociation stimulator 1 isoform X2

      Conserved Domains (3) summary
      smart00185
      Location:168 → 211
      ARM; Armadillo/beta-catenin-like repeats
      PLN03200
      Location:179 → 330
      PLN03200; cellulose synthase-interactive protein; Provisional
      sd00043
      Location:173 → 212
      ARM; armadillo repeat [structural motif]

    3. XM_006501428.5 → XP_006501491.1  rap1 GTPase-GDP dissociation stimulator 1 isoform X1

      See identical proteins and their annotated locations for XP_006501491.1

      Conserved Domains (3) summary
      smart00185
      Location:168 → 211
      ARM; Armadillo/beta-catenin-like repeats
      sd00043
      Location:173 → 212
      ARM; armadillo repeat [structural motif]
      cl26969
      Location:48 → 213
      Vitellogenin_N; Lipoprotein amino terminal region

    4. XM_006501429.5 → XP_006501492.1  rap1 GTPase-GDP dissociation stimulator 1 isoform X1

      See identical proteins and their annotated locations for XP_006501492.1

      Conserved Domains (3) summary
      smart00185
      Location:168 → 211
      ARM; Armadillo/beta-catenin-like repeats
      sd00043
      Location:173 → 212
      ARM; armadillo repeat [structural motif]
      cl26969
      Location:48 → 213
      Vitellogenin_N; Lipoprotein amino terminal region

    5. XM_036163087.1 → XP_036018980.1  rap1 GTPase-GDP dissociation stimulator 1 isoform X3

      Conserved Domains (4) summary
      PLN03200
      Location:42 → 264
      PLN03200; cellulose synthase-interactive protein; Provisional
      sd00043
      Location:91 → 116
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:86 → 117
      Arm; Armadillo/beta-catenin-like repeat
      cl26969
      Location:226 → 393
      Vitellogenin_N; Lipoprotein amino terminal region

    6. XM_036163088.1 → XP_036018981.1  rap1 GTPase-GDP dissociation stimulator 1 isoform X4

      Conserved Domains (3) summary
      sd00043
      Location:44 → 71
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:86 → 117
      Arm; Armadillo/beta-catenin-like repeat
      cl26969
      Location:177 → 344
      Vitellogenin_N; Lipoprotein amino terminal region
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E9Q912.1 GenPept UniProtKB/Swiss-Prot:E9Q912

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous