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    Slc25a24 solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 24 [ Mus musculus (house mouse) ]

    Gene ID: 229731, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Slc25a24provided by MGI
    Official Full Name
    solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 24provided by MGI
    Primary source
    MGI:MGI:1917160
    See related
    Ensembl:ENSMUSG00000040322 AllianceGenome:MGI:1917160
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SCaMC-1; 2610016M12Rik
    Summary
    Predicted to enable ATP transmembrane transporter activity and calcium ion binding activity. Predicted to be involved in several processes, including ATP transport; cellular response to calcium ion; and cellular response to oxidative stress. Located in mitochondrion. Is expressed in cartilage; genitourinary system; and trachea. Orthologous to human SLC25A24 (solute carrier family 25 member 24). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in colon adult (RPKM 19.5), large intestine adult (RPKM 18.1) and 21 other tissues See more
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    Genomic context

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    Location:
    3 F3; 3 48.13 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (109030465..109075725)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (109123149..109168409)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 25, member 54 Neighboring gene predicted gene, 19391 Neighboring gene STARR-seq mESC enhancer starr_08697 Neighboring gene zona pellucida binding protein 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_08698 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:109144693-109144846 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:109164872-109165133 Neighboring gene vav 3 oncogene Neighboring gene STARR-positive B cell enhancer mm9_chr3:109251268-109251568 Neighboring gene STARR-seq mESC enhancer starr_08700 Neighboring gene STARR-seq mESC enhancer starr_08701 Neighboring gene STARR-seq mESC enhancer starr_08702 Neighboring gene STARR-seq mESC enhancer starr_08703

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. SLC25A24 as a novel susceptibility gene for low fat mass in humans and mice. Urano T, et al. J Clin Endocrinol Metab, 2015 Apr. PMID 25599384
    2. SCaMC-1 promotes cancer cell survival by desensitizing mitochondrial permeability transition via ATP/ADP-mediated matrix Ca(2+) buffering. Traba J, et al. Cell Death Differ, 2012 Apr. PMID 22015608, Free PMC Article
    3. Glucagon regulation of oxidative phosphorylation requires an increase in matrix adenine nucleotide content through Ca2+ activation of the mitochondrial ATP-Mg/Pi carrier SCaMC-3. Amigo I, et al. J Biol Chem, 2013 Mar 15. PMID 23344948, Free PMC Article
    4. Identification of a novel human subfamily of mitochondrial carriers with calcium-binding domains. del Arco A, et al. J Biol Chem, 2004 Jun 4. PMID 15054102
    5. The ubiquitin ligase Ubr4 controls stability of podocin/MEC-2 supercomplexes. Rinschen MM, et al. Hum Mol Genet, 2016 Apr 1. PMID 26792178, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Arginine-methylated c-Myc affects mitochondrial mitophagy in mouse acute kidney injury via Slc25a24.
      Title: Arginine-methylated c-Myc affects mitochondrial mitophagy in mouse acute kidney injury via Slc25a24.
    2. Genetic analyses in human and mouse models revealed the importance of SLC25A24/Slc25a24 in the regulation of body fat mass and adipogenesis.
      Title: SLC25A24 as a novel susceptibility gene for low fat mass in humans and mice.
    3. SCaMC-1 exerts a negative feedback control between cellular Ca(2+) overload and mPT-dependent cell death, suggesting that the carrier might represent a novel target for cancer therapy.
      Title: SCaMC-1 promotes cancer cell survival by desensitizing mitochondrial permeability transition via ATP/ADP-mediated matrix Ca(2+) buffering.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ADP:phosphate antiporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP:phosphate antiporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables adenine nucleotide transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ADP transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ATP transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adenine nucleotide transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to calcium ion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial ATP transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial adenyl nucleotide antiporter SLC25A24
    Names
    calcium-binding mitochondrial carrier protein SCaMC-1
    small calcium-binding mitochondrial carrier protein 1
    solute carrier family 25 member 24

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172685.3 → NP_766273.1  mitochondrial adenyl nucleotide antiporter SLC25A24

      See identical proteins and their annotated locations for NP_766273.1

      Status: PROVISIONAL

      Source sequence(s)
      AL671921, AL845310
      Consensus CDS
      CCDS17772.1
      UniProtKB/Swiss-Prot
      Q3TCQ2, Q3THY3, Q7TPC2, Q8BMD8
      Related
      ENSMUSP00000029477.7, ENSMUST00000029477.11
      Conserved Domains (4) summary
      cd00051
      Location:28 → 85
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      PTZ00169
      Location:199 → 470
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:194 → 281
      Mito_carr; Mitochondrial carrier protein
      pfam13499
      Location:25 → 84
      EF-hand_7; EF-hand domain pair

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      109030465..109075725
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BMD8.1 GenPept UniProtKB/Swiss-Prot:Q8BMD8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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