Gpr61 G protein-coupled receptor 61 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gpr61provided by MGI
Official Full Name: G protein-coupled receptor 61provided by MGI
Primary source: MGI:MGI:2441719
See related: Ensembl:ENSMUSG00000046793 AllianceGenome:MGI:2441719
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable G protein-coupled receptor activity and arrestin family protein binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway and positive regulation of cAMP-mediated signaling. Predicted to act upstream of or within signal transduction. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of receptor complex. Predicted to be active in endosome and plasma membrane. Orthologous to human GPR61 (G protein-coupled receptor 61). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in frontal lobe adult (RPKM 3.4), cortex adult (RPKM 2.7) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F2.3; 3 46.84 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (108055660..108062218, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (108148321..108154932, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These findings suggest that GPR61 is involved in the regulation of food intake and body weight
Title: Characterization of metabolic phenotypes of mice lacking GPR61, an orphan G-protein coupled receptor.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (5)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables arrestin family protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in ligand-independent adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: G-protein coupled receptor 61

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001305461.2 → NP_001292390.1 G-protein coupled receptor 61

See identical proteins and their annotated locations for NP_001292390.1

Status: VALIDATED

Source sequence(s)

AL671854

Consensus CDS

CCDS17752.1

UniProtKB/Swiss-Prot

Q3UZR6, Q8C010

Related

ENSMUSP00000111988.2, ENSMUST00000116284.2

Conserved Domains (1) summary

cd15220
Location:44 → 352

7tmA_GPR61_GPR62-like; G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001411298.1 → NP_001398227.1 G-protein coupled receptor 61

Status: VALIDATED

Source sequence(s)

AL671854

UniProtKB/Swiss-Prot

Q3UZR6, Q8C010

Related

ENSMUSP00000055557.2, ENSMUST00000062028.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

108055660..108062218 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_175470.4: Suppressed sequence

Description

NM_175470.4: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.