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    Ciart circadian associated repressor of transcription [ Mus musculus (house mouse) ]

    Gene ID: 229599, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Ciartprovided by MGI
    Official Full Name
    circadian associated repressor of transcriptionprovided by MGI
    Primary source
    MGI:MGI:2684975
    See related
    Ensembl:ENSMUSG00000038550 AllianceGenome:MGI:2684975
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm129; Chrono
    Summary
    Enables E-box binding activity. Involved in circadian regulation of gene expression; locomotor rhythm; and negative regulation of transcription, DNA-templated. Located in nucleus. Orthologous to human CIART (circadian associated repressor of transcription). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in bladder adult (RPKM 9.0), cortex adult (RPKM 8.4) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    3 F2.1; 3 41.42 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (95785812..95790012, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (95878500..95882257, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene pre-mRNA processing factor 3 Neighboring gene STARR-positive B cell enhancer ABC_E10199 Neighboring gene RIKEN cDNA C920021L13 gene Neighboring gene mitochondrial ribosomal protein S21 Neighboring gene STARR-positive B cell enhancer ABC_E9562 Neighboring gene cDNA sequence BC028528 Neighboring gene STARR-positive B cell enhancer ABC_E2673 Neighboring gene aph1 homolog A, gamma secretase subunit Neighboring gene carbonic anhydrase 14 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:95732686-95732932 Neighboring gene predicted gene, 46815

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CHRONO and DEC1/DEC2 compensate for lack of CRY1/CRY2 in expression of coherent circadian rhythm but not in generation of circadian oscillation in the neonatal mouse SCN. Ono D, et al. Sci Rep, 2021 Sep 28. PMID 34584158, Free PMC Article
    2. Machine learning helps identify CHRONO as a circadian clock component. Anafi RC, et al. PLoS Biol, 2014 Apr. PMID 24737000, Free PMC Article
    3. Gene model 129 (Gm129) encodes a novel transcriptional repressor that modulates circadian gene expression. Annayev Y, et al. J Biol Chem, 2014 Feb 21. PMID 24385426, Free PMC Article
    4. A catalogue of genes in mouse embryonal carcinoma F9 cells identified with expressed sequence tags. Nishiguchi S, et al. J Biochem, 1996 Apr. PMID 8743579
    5. A novel protein, CHRONO, functions as a core component of the mammalian circadian clock. Goriki A, et al. PLoS Biol, 2014 Apr. PMID 24736997, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CHRONO and DEC1/DEC2 compensate for lack of CRY1/CRY2 in expression of coherent circadian rhythm but not in generation of circadian oscillation in the neonatal mouse SCN.
      Title: CHRONO and DEC1/DEC2 compensate for lack of CRY1/CRY2 in expression of coherent circadian rhythm but not in generation of circadian oscillation in the neonatal mouse SCN.
    2. CHRONO interferes with the ability of BMAL1 to recruit CBP, a bona fide histone acetylase and key transcriptional coactivator of the circadian clock.
      Title: Machine learning helps identify CHRONO as a circadian clock component.
    3. Chrono binds to the regulatory region of clock genes and its occupancy oscillates in a circadian manner.
      Title: A novel protein, CHRONO, functions as a core component of the mammalian circadian clock.
    4. The GM129 protein contributes to the transcriptional feedback loop by modulating CLOCK.BMAL1 activity as a transcriptional repressor.
      Title: Gene model 129 (Gm129) encodes a novel transcriptional repressor that modulates circadian gene expression.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 
    • Endonuclease-mediated (5) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables E-box binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in circadian regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in circadian regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in locomotor rhythm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within rhythmic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    circadian-associated transcriptional repressor
    Names
    chIP-derived repressor of network oscillator
    computationally highlighted repressor of the network oscillator

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033302.3 → NP_001028474.1  circadian-associated transcriptional repressor isoform 1

      See identical proteins and their annotated locations for NP_001028474.1

      Status: VALIDATED

      Source sequence(s)
      AC092855
      Consensus CDS
      CCDS50997.1
      UniProtKB/Swiss-Prot
      Q3TQ03, Q3U1B8
      UniProtKB/TrEMBL
      A2RTE4
      Related
      ENSMUSP00000049308.4, ENSMUST00000036418.10
      Conserved Domains (1) summary
      pfam15673
      Location:85 → 360
      Ciart; Circadian-associated transcriptional repressor

    2. NM_001411319.1 → NP_001398248.1  circadian-associated transcriptional repressor isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC092855
      UniProtKB/Swiss-Prot
      Q3TQ03, Q3U1B8
      UniProtKB/TrEMBL
      A2RTE4

    3. NM_001411320.1 → NP_001398249.1  circadian-associated transcriptional repressor isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC092855
      UniProtKB/Swiss-Prot
      Q3TQ03, Q3U1B8
      UniProtKB/TrEMBL
      A2RTE4

    4. NM_001411321.1 → NP_001398250.1  circadian-associated transcriptional repressor isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC092855
      UniProtKB/Swiss-Prot
      Q3TQ03, Q3U1B8
      UniProtKB/TrEMBL
      A2RTE4

    5. NM_001411322.1 → NP_001398251.1  circadian-associated transcriptional repressor isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC092855
      UniProtKB/Swiss-Prot
      Q3TQ03, Q3U1B8
      UniProtKB/TrEMBL
      A2RTE4

    6. NM_001411323.1 → NP_001398252.1  circadian-associated transcriptional repressor isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC092855
      UniProtKB/Swiss-Prot
      Q3TQ03, Q3U1B8
      UniProtKB/TrEMBL
      A2RTE4
      Related
      ENSMUSP00000124943.2, ENSMUST00000159739.8

    7. NM_001411324.1 → NP_001398253.1  circadian-associated transcriptional repressor isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC092855

    8. NM_001411325.1 → NP_001398254.1  circadian-associated transcriptional repressor isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC092855

    9. NM_001411326.1 → NP_001398255.1  circadian-associated transcriptional repressor isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC092855

    10. NM_001411327.1 → NP_001398256.1  circadian-associated transcriptional repressor isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC092855

    11. NM_001411328.1 → NP_001398257.1  circadian-associated transcriptional repressor isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC092855

    12. NM_001411329.1 → NP_001398258.1  circadian-associated transcriptional repressor isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC092855

    13. NM_001411330.1 → NP_001398259.1  circadian-associated transcriptional repressor isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC092855

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      95785812..95790012 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3TQ03.1 GenPept UniProtKB/Swiss-Prot:Q3TQ03

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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