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    Isg20l2 interferon stimulated exonuclease gene 20-like 2 [ Mus musculus (house mouse) ]

    Gene ID: 229504, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Isg20l2provided by MGI
    Official Full Name
    interferon stimulated exonuclease gene 20-like 2provided by MGI
    Primary source
    MGI:MGI:2140076
    See related
    Ensembl:ENSMUSG00000048039 AllianceGenome:MGI:2140076
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4930429N24
    Summary
    Predicted to enable exonuclease activity. Predicted to act upstream of or within ribosome biogenesis. Predicted to be active in nucleus. Is expressed in several structures, including brain ventricular layer; dorsal root ganglion; submandibular gland primordium; thymus primordium; and tooth. Orthologous to human ISG20L2 (interferon stimulated exonuclease gene 20 like 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 26.3), CNS E11.5 (RPKM 14.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    3 F1; 3 38.78 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (87837602..87847994)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (87930314..87940686)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_08165 Neighboring gene heparin binding growth factor Neighboring gene STARR-positive B cell enhancer ABC_E10190 Neighboring gene mitochondrial ribosomal protein L24 Neighboring gene methyltransferase like 25B Neighboring gene STARR-positive B cell enhancer ABC_E9556 Neighboring gene cellular retinoic acid binding protein II Neighboring gene STARR-positive B cell enhancer ABC_E9216 Neighboring gene predicted gene, 32518

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Transcription factor Foxp3 and its protein partners form a complex regulatory network. Rudra D, et al. Nat Immunol, 2012 Oct. PMID 22922362, Free PMC Article
    2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    3. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article
    4. The central role of EED in the orchestration of polycomb group complexes. Cao Q, et al. Nat Commun, 2014. PMID 24457600, Free PMC Article
    5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3'-5'-RNA exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    interferon-stimulated 20 kDa exonuclease-like 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177663.5 → NP_808331.1  interferon-stimulated 20 kDa exonuclease-like 2

      See identical proteins and their annotated locations for NP_808331.1

      Status: VALIDATED

      Source sequence(s)
      AC158233
      Consensus CDS
      CCDS17459.1
      UniProtKB/Swiss-Prot
      Q3U1G5, Q4KMV7, Q8BKA9
      UniProtKB/TrEMBL
      A0A0R4J0R3
      Related
      ENSMUSP00000059783.7, ENSMUST00000055984.7
      Conserved Domains (1) summary
      cd06149
      Location:195 → 351
      ISG20; DEDDh 3'-5' exonuclease domain of Interferon Stimulated Gene product of 20 kDa, and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      87837602..87847994
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163048.1 → XP_036018941.1  interferon-stimulated 20 kDa exonuclease-like 2 isoform X1

      UniProtKB/Swiss-Prot
      Q3U1G5, Q4KMV7, Q8BKA9
      UniProtKB/TrEMBL
      A0A0R4J0R3
      Conserved Domains (1) summary
      cd06149
      Location:195 → 351
      ISG20; DEDDh 3'-5' exonuclease domain of Interferon Stimulated Gene product of 20 kDa, and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3U1G5.2 GenPept UniProtKB/Swiss-Prot:Q3U1G5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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