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    Mettl25b methyltransferase like 25B [ Mus musculus (house mouse) ]

    Gene ID: 229503, updated on 5-Mar-2024

    Summary

    Official Symbol
    Mettl25bprovided by MGI
    Official Full Name
    methyltransferase like 25Bprovided by MGI
    Primary source
    MGI:MGI:2387197
    See related
    Ensembl:ENSMUSG00000004896 AllianceGenome:MGI:2387197
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rrnad1
    Summary
    Predicted to be located in membrane. Predicted to be integral component of membrane. Orthologous to human METTL25B (methyltransferase like 25B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 11.5), CNS E14 (RPKM 10.8) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    Location:
    3 F1; 3 38.78 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (87829908..87838337, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (87922601..87930719, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene papillary renal cell carcinoma (translocation-associated) Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:87689595-87689778 Neighboring gene STARR-seq mESC enhancer starr_08164 Neighboring gene STARR-seq mESC enhancer starr_08165 Neighboring gene heparin binding growth factor Neighboring gene STARR-positive B cell enhancer ABC_E10190 Neighboring gene mitochondrial ribosomal protein L24 Neighboring gene STARR-positive B cell enhancer ABC_E9556 Neighboring gene interferon stimulated exonuclease gene 20-like 2 Neighboring gene cellular retinoic acid binding protein II Neighboring gene STARR-positive B cell enhancer ABC_E9216 Neighboring gene predicted gene, 32518

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    General gene information

    Markers

    Clone Names

    • MGC38548

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    methyltransferase-like protein 25B
    Names
    protein RRNAD1
    ribosomal RNA adenine dimethylase domain containing 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153562.4NP_705790.3  methyltransferase-like protein 25B

      See identical proteins and their annotated locations for NP_705790.3

      Status: VALIDATED

      Source sequence(s)
      AA611348, AI592533, AK035389, BB684061, BB871494, BY035934, BY617418
      Consensus CDS
      CCDS17458.1
      UniProtKB/Swiss-Prot
      G3X8Q8, Q8BZG5, Q8CII4
      Related
      ENSMUSP00000005016.10, ENSMUST00000005016.16
      Conserved Domains (1) summary
      pfam13679
      Location:133293
      Methyltransf_32; Methyltransferase domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      87829908..87838337 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501338.5XP_006501401.1  methyltransferase-like protein 25B isoform X1

      Conserved Domains (1) summary
      pfam13679
      Location:124284
      Methyltransf_32; Methyltransferase domain
    2. XM_030252571.2XP_030108431.1  methyltransferase-like protein 25B isoform X5

      Conserved Domains (1) summary
      pfam13679
      Location:63223
      Methyltransf_32; Methyltransferase domain
    3. XM_036163045.1XP_036018938.1  methyltransferase-like protein 25B isoform X3

      Conserved Domains (1) summary
      cl17173
      Location:133272
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    4. XM_006501340.4XP_006501403.1  methyltransferase-like protein 25B isoform X4

      UniProtKB/TrEMBL
      E9PUL0
      Related
      ENSMUSP00000125365.2, ENSMUST00000160074.8
      Conserved Domains (1) summary
      pfam13679
      Location:69229
      Methyltransf_32; Methyltransferase domain
    5. XM_030252572.1XP_030108432.1  methyltransferase-like protein 25B isoform X6

      Conserved Domains (1) summary
      cl17173
      Location:2123
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    6. XM_030252570.2XP_030108430.1  methyltransferase-like protein 25B isoform X2

      Conserved Domains (1) summary
      cl17173
      Location:124263
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    7. XM_036163047.1XP_036018940.1  methyltransferase-like protein 25B isoform X7

    RNA

    1. XR_003954313.2 RNA Sequence

    2. XR_375513.5 RNA Sequence

    3. XR_003954311.1 RNA Sequence

    4. XR_375514.5 RNA Sequence

    5. XR_003954312.1 RNA Sequence

    6. XR_003954310.1 RNA Sequence

    7. XR_375515.5 RNA Sequence

    8. XR_003954308.2 RNA Sequence