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    Fhdc1 FH2 domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 229474, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Fhdc1provided by MGI
    Official Full Name
    FH2 domain containing 1provided by MGI
    Primary source
    MGI:MGI:2684972
    See related
    Ensembl:ENSMUSG00000041842 AllianceGenome:MGI:2684972
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm126; 6330505N24Rik
    Summary
    Enables actin binding activity and microtubule binding activity. Involved in Golgi ribbon formation and cilium assembly. Located in Golgi apparatus and cytoplasmic microtubule. Is expressed in alimentary system; brain; heart; lung; and testis. Orthologous to human FHDC1 (FH2 domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis adult (RPKM 8.5), liver E14.5 (RPKM 7.5) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    3 F1; 3 37.67 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (84349503..84387746, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (84442191..84480439, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene tripartite motif-containing 2 Neighboring gene nuclear encoded tRNA glycine 9 (anticodon GCC) Neighboring gene predicted gene, 40078 Neighboring gene STARR-positive B cell enhancer ABC_E3441 Neighboring gene RIKEN cDNA 4930565D16 gene Neighboring gene STARR-seq mESC enhancer starr_08085 Neighboring gene ADP-ribosylation factor interacting protein 1 Neighboring gene STARR-positive B cell enhancer mm9_chr3:84346416-84346716 Neighboring gene high mobility group box 3 pseudogene Neighboring gene predicted gene, 35410

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Actin- and microtubule-dependent regulation of Golgi morphology by FHDC1. Copeland SJ, et al. Mol Biol Cell, 2016 Jan 15. PMID 26564798, Free PMC Article
    2. INF1 is a novel microtubule-associated formin. Young KG, et al. Mol Biol Cell, 2008 Dec. PMID 18815276, Free PMC Article
    3. Actin-dependent regulation of cilia length by the inverted formin FHDC1. Copeland SJ, et al. Mol Biol Cell, 2018 Jul 1. PMID 29742020, Free PMC Article
    4. Expression of multiple formins in adult tissues and during developmental stages of mouse brain. Dutta P, et al. Gene Expr Patterns, 2015 Sep-Nov. PMID 26272686
    5. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FHDC1 plays a role in coordinating cytoskeletal dynamics during normal cilia assembly.
      Title: Actin-dependent regulation of cilia length by the inverted formin FHDC1.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi ribbon formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in Golgi ribbon formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in actin filament polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell projection organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in actin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    FH2 domain-containing protein 1
    Names
    inverted formin-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033301.4 → NP_001028473.2  FH2 domain-containing protein 1

      See identical proteins and their annotated locations for NP_001028473.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC102140
      Consensus CDS
      CCDS17438.1
      UniProtKB/Swiss-Prot
      B9EHC4, Q3ULZ2, Q69ZC2, Q8C0A0
      Related
      ENSMUSP00000103317.2, ENSMUST00000107689.7
      Conserved Domains (3) summary
      PHA03247
      Location:823 → 1064
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:524 → 981
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam02181
      Location:94 → 458
      FH2; Formin Homology 2 Domain

    2. NM_001205355.1 → NP_001192284.1  FH2 domain-containing protein 1

      See identical proteins and their annotated locations for NP_001192284.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC102140
      Consensus CDS
      CCDS17438.1
      UniProtKB/Swiss-Prot
      B9EHC4, Q3ULZ2, Q69ZC2, Q8C0A0
      Related
      ENSMUSP00000088525.2, ENSMUST00000091002.8
      Conserved Domains (3) summary
      PHA03247
      Location:823 → 1064
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:524 → 981
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam02181
      Location:94 → 458
      FH2; Formin Homology 2 Domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      84349503..84387746 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501328.5 → XP_006501391.1  FH2 domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006501391.1

      UniProtKB/Swiss-Prot
      B9EHC4, Q3ULZ2, Q69ZC2, Q8C0A0
      Conserved Domains (3) summary
      PHA03247
      Location:823 → 1064
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:524 → 981
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam02181
      Location:94 → 458
      FH2; Formin Homology 2 Domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3ULZ2.3 GenPept UniProtKB/Swiss-Prot:Q3ULZ2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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