Nudt6 nudix hydrolase 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nudt6provided by MGI
Official Full Name: nudix hydrolase 6provided by MGI
Primary source: MGI:MGI:2387618
See related: Ensembl:ENSMUSG00000050174 AllianceGenome:MGI:2387618
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Asfgf2b
Summary: Predicted to enable ADP-ribose diphosphatase activity; NAD binding activity; and NADH pyrophosphatase activity. Predicted to be involved in negative regulation of cell cycle and negative regulation of cell population proliferation. Predicted to be located in cytoplasm. Is expressed in brain. Orthologous to human NUDT6 (nudix hydrolase 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in adrenal adult (RPKM 10.9), mammary gland adult (RPKM 7.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 B; 3 18.46 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (37459126..37474391, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (37404982..37420242, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Markers

RH94418 (e-PCR)
- UniSTS:119666

Results_ER_8_28_95_2_4.seq (e-PCR)
- UniSTS:125572

NoName (e-PCR)
- UniSTS:490668

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ADP-ribose diphosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables NAD binding	IBA Inferred from Biological aspect of Ancestor more info
enables NADH pyrophosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: nucleoside diphosphate-linked moiety X motif 6

Names: antisense basic fibroblast growth factor B; nudix (nucleoside diphosphate linked moiety X)-type motif 6; nudix motif 6

NP_001277973.1

EC 3.6.1.-

NP_705789.1

EC 3.6.1.-

XP_006535522.1

EC 3.6.1.-

XP_006535523.1

EC 3.6.1.-

XP_006535525.1

EC 3.6.1.-

XP_011247972.1

EC 3.6.1.-

XP_011247973.1

EC 3.6.1.-

XP_011247974.1

EC 3.6.1.-

XP_011247976.1

EC 3.6.1.-

XP_011247977.1

EC 3.6.1.-

XP_017175028.1

EC 3.6.1.-

XP_030108418.1

EC 3.6.1.-

XP_030108419.1

EC 3.6.1.-

XP_030108420.1

EC 3.6.1.-

XP_036018924.1

EC 3.6.1.-

XP_036018925.1

EC 3.6.1.-

XP_036018926.1

EC 3.6.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001291044.1 → NP_001277973.1 nucleoside diphosphate-linked moiety X motif 6 isoform 1

See identical proteins and their annotated locations for NP_001277973.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AL669927

Consensus CDS

CCDS71237.1

UniProtKB/Swiss-Prot

Q8CH40, Q8R2T3

UniProtKB/TrEMBL

Q3ULU4

Related

ENSMUSP00000056219.7, ENSMUST00000052645.13

Conserved Domains (1) summary

cd04670
Location:139 → 272

Nudix_Hydrolase_12; Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly ...
NM_153561.3 → NP_705789.1 nucleoside diphosphate-linked moiety X motif 6 isoform 2

See identical proteins and their annotated locations for NP_705789.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.

Source sequence(s)

AL669927

Consensus CDS

CCDS38418.1

UniProtKB/Swiss-Prot

Q8CH40, Q8R2T3

UniProtKB/TrEMBL

A0A0R4J176

Related

ENSMUSP00000096733.3, ENSMUST00000099130.9

Conserved Domains (1) summary

cd04670
Location:139 → 271

Nudix_Hydrolase_12; Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

37459126..37474391 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011249671.3 → XP_011247973.1 nucleoside diphosphate-linked moiety X motif 6 isoform X4

Conserved Domains (2) summary

cd04670
Location:71 → 204

Nudix_Hydrolase_12; Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly ...

pfam18290
Location:8 → 58

Nudix_hydro; Nudix hydrolase domain
XM_030252560.2 → XP_030108420.1 nucleoside diphosphate-linked moiety X motif 6 isoform X10

Conserved Domains (1) summary

cl00447
Location:10 → 118

Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...
XM_036163033.1 → XP_036018926.1 nucleoside diphosphate-linked moiety X motif 6 isoform X12

UniProtKB/TrEMBL

Q8CH41

Conserved Domains (1) summary

cl00447
Location:1 → 106

Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...
XM_030252559.2 → XP_030108419.1 nucleoside diphosphate-linked moiety X motif 6 isoform X10

Conserved Domains (1) summary

cl00447
Location:10 → 118

Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...
XM_006535459.2 → XP_006535522.1 nucleoside diphosphate-linked moiety X motif 6 isoform X3

Conserved Domains (2) summary

cd04670
Location:86 → 219

Nudix_Hydrolase_12; Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly ...

pfam18290
Location:26 → 73

Nudix_hydro; Nudix hydrolase domain
XM_006535460.4 → XP_006535523.1 nucleoside diphosphate-linked moiety X motif 6 isoform X10

Conserved Domains (1) summary

cl00447
Location:10 → 118

Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...
XM_006535462.1 → XP_006535525.1 nucleoside diphosphate-linked moiety X motif 6 isoform X12

See identical proteins and their annotated locations for XP_006535525.1

UniProtKB/TrEMBL

Q8CH41

Related

ENSMUSP00000142653.2, ENSMUST00000146324.8

Conserved Domains (1) summary

cl00447
Location:1 → 106

Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...
XM_036163032.1 → XP_036018925.1 nucleoside diphosphate-linked moiety X motif 6 isoform X11

Conserved Domains (1) summary

cl00447
Location:10 → 117

Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...
XM_036163031.1 → XP_036018924.1 nucleoside diphosphate-linked moiety X motif 6 isoform X5

Conserved Domains (2) summary

cd04670
Location:71 → 203

Nudix_Hydrolase_12; Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly ...

pfam18290
Location:8 → 58

Nudix_hydro; Nudix hydrolase domain
XM_011249670.1 → XP_011247972.1 nucleoside diphosphate-linked moiety X motif 6 isoform X2

UniProtKB/Swiss-Prot

Q8CH40, Q8R2T3

Conserved Domains (2) summary

pfam18290
Location:43 → 126

Nudix_hydro; Nudix hydrolase domain

cl00447
Location:142 → 234

Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...
XM_017319539.1 → XP_017175028.1 nucleoside diphosphate-linked moiety X motif 6 isoform X1

UniProtKB/Swiss-Prot

Q8CH40, Q8R2T3

Conserved Domains (2) summary

pfam18290
Location:43 → 126

Nudix_hydro; Nudix hydrolase domain

cl00447
Location:146 → 235

Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...
XM_011249675.2 → XP_011247977.1 nucleoside diphosphate-linked moiety X motif 6 isoform X9

See identical proteins and their annotated locations for XP_011247977.1

UniProtKB/TrEMBL

A0A0G2JDN4

Conserved Domains (1) summary

pfam18290
Location:43 → 126

Nudix_hydro; Nudix hydrolase domain
XM_011249674.1 → XP_011247976.1 nucleoside diphosphate-linked moiety X motif 6 isoform X8

See identical proteins and their annotated locations for XP_011247976.1

UniProtKB/TrEMBL

A0A0G2JDN4

Conserved Domains (1) summary

pfam18290
Location:43 → 126

Nudix_hydro; Nudix hydrolase domain
XM_011249672.1 → XP_011247974.1 nucleoside diphosphate-linked moiety X motif 6 isoform X6

UniProtKB/TrEMBL

A0A0G2JDN4

Conserved Domains (2) summary

pfam18290
Location:43 → 126

Nudix_hydro; Nudix hydrolase domain

cl00447
Location:139 → 181

Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...
XM_030252558.1 → XP_030108418.1 nucleoside diphosphate-linked moiety X motif 6 isoform X7

UniProtKB/TrEMBL

A0A0G2JDN4

Conserved Domains (1) summary

pfam18290
Location:43 → 126

Nudix_hydro; Nudix hydrolase domain