Cbln4 cerebellin 4 precursor protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cbln4provided by MGI
Official Full Name: cerebellin 4 precursor proteinprovided by MGI
Primary source: MGI:MGI:2154433
See related: Ensembl:ENSMUSG00000067578 AllianceGenome:MGI:2154433
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Involved in inhibitory synapse assembly. Acts upstream of or within protein secretion. Located in GABA-ergic synapse and extracellular space. Is expressed in central nervous system; genitourinary system; limb; and sensory organ. Orthologous to human CBLN4 (cerebellin 4 precursor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in CNS E18 (RPKM 6.7), whole brain E14.5 (RPKM 4.3) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H3; 2 94.74 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (171878256..171885386, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (172036336..172043466, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Transsynaptic cerebellin 4-neogenin 1 signaling mediates LTP in the mouse dentate gyrus.
Title: Transsynaptic cerebellin 4-neogenin 1 signaling mediates LTP in the mouse dentate gyrus.
Cbln2 and Cbln4 are expressed in distinct MHb neurons that contribute to different behaviors.
Title: Cbln2 and Cbln4 are expressed in distinct medial habenula-interpeduncular projections and contribute to different behavioral outputs.
Results show that Cbln1, Cbln2, and Cbln4 are abundantly expressed in nearly all brain regions, but exhibit strikingly different expression patterns and developmental dynamics. Using newly generated knockin reporter mice for Cbln2 and Cbln4, we find that Cbln2 and Cbln4 are not universally expressed in all neurons, but only in specific subsets of neurons.
Title: Cerebellins are differentially expressed in selective subsets of neurons throughout the brain.
It is a synaptic protein, enhances inhibitory activity and resistance of neurons to amyloid-beta toxicity.
Title: Cerebellin 4, a synaptic protein, enhances inhibitory activity and resistance of neurons to amyloid-β toxicity.
that neurons expressing Cblns 1, 2, and 4 tend to occupy different laminar positions within the dorsal spinal cord
Title: Parcellation of cerebellins 1, 2, and 4 among different subpopulations of dorsal horn neurons in mouse spinal cord.
SRY and SOX9 contribute to the male-specific upregulation of Cbln4 in the developing testis.
Title: The cerebellin 4 precursor gene is a direct target of SRY and SOX9 in mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Cbln4 (e-PCR), detects polymorphism
- UniSTS:464656

Cbln4 (e-PCR), detects polymorphism
- UniSTS:525886

Cbln4 (e-PCR), detects polymorphism
- UniSTS:525887

AI848962 (e-PCR)
- UniSTS:178781

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in inhibitory synapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in trans-synaptic signaling, modulating synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in trans-synaptic signaling, modulating synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	NAS Non-traceable Author Statement more info	PubMed
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
is_active_in synaptic cleft	IDA Inferred from Direct Assay more info	PubMed
is_active_in synaptic cleft	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in synaptic cleft	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: cerebellin-4

Names: cerebellin-like glycoprotein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.