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    Ncoa5 nuclear receptor coactivator 5 [ Mus musculus (house mouse) ]

    Gene ID: 228869, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Ncoa5provided by MGI
    Official Full Name
    nuclear receptor coactivator 5provided by MGI
    Primary source
    MGI:MGI:2385165
    See related
    Ensembl:ENSMUSG00000039804 AllianceGenome:MGI:2385165
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CIA
    Summary
    Enables chromatin binding activity. Acts upstream of or within glucose homeostasis and negative regulation of insulin receptor signaling pathway. Predicted to be located in actin cytoskeleton and nucleoplasm. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; immune system; and nervous system. Orthologous to human NCOA5 (nuclear receptor coactivator 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 28.4), CNS E18 (RPKM 25.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ncoa5 in Genome Data Viewer
    Location:
    2 H3; 2 85.32 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (164842273..164876794, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (165000353..165034871, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:164768440-164768694 Neighboring gene matrix metallopeptidase 9 Neighboring gene solute carrier family 12, member 5 Neighboring gene heat shock protein 90, alpha (cytosolic), class A member 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_06346 Neighboring gene STARR-positive B cell enhancer ABC_E2060 Neighboring gene STARR-positive B cell enhancer ABC_E4518 Neighboring gene CD40 antigen Neighboring gene RIKEN cDNA 1700025C18 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. NCOA5 deficiency promotes a unique liver protumorigenic microenvironment through p21(WAF1/CIP1) overexpression, which is reversed by metformin. Williams M, et al. Oncogene, 2020 May. PMID 32203160, Free PMC Article
    2. NCOA5 Haplo-insufficiency Results in Male Mouse Infertility through Increased IL-6 Expression in the Epididymis. Gao S, et al. Sci Rep, 2019 Oct 29. PMID 31664153, Free PMC Article
    3. An LXR-NCOA5 gene regulatory complex directs inflammatory crosstalk-dependent repression of macrophage cholesterol efflux. Gillespie MA, et al. EMBO J, 2015 May 5. PMID 25755249, Free PMC Article
    4. CIA, a novel estrogen receptor coactivator with a bifunctional nuclear receptor interacting determinant. Sauvé F, et al. Mol Cell Biol, 2001 Jan. PMID 11113208, Free PMC Article
    5. NCOA5 haploinsufficiency results in glucose intolerance and subsequent hepatocellular carcinoma. Gao S, et al. Cancer Cell, 2013 Dec 9. PMID 24332041, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NCOA5 Haploinsufficiency in Myeloid-Lineage Cells Sufficiently Causes Nonalcoholic Steatohepatitis and Hepatocellular Carcinoma.
      Title: NCOA5 Haploinsufficiency in Myeloid-Lineage Cells Sufficiently Causes Nonalcoholic Steatohepatitis and Hepatocellular Carcinoma.
    2. NCOA5 deficiency promotes a unique liver protumorigenic microenvironment through p21(WAF1/CIP1) overexpression, which is reversed by metformin.
      Title: NCOA5 deficiency promotes a unique liver protumorigenic microenvironment through p21(WAF1/CIP1) overexpression, which is reversed by metformin.
    3. NCOA5 functions as an LXR corepressor.A central role for NCOA5 in mediating crosstalk between pro-inflammatory and anti-inflammatory pathways that results in repression of macrophage cholesterol efflux.
      Title: An LXR-NCOA5 gene regulatory complex directs inflammatory crosstalk-dependent repression of macrophage cholesterol efflux.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC28864

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within glucose homeostasis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of insulin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of insulin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    nuclear receptor coactivator 5
    Names
    NCoA-5
    coactivator independent of AF-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_144892.1 → NP_659141.1  nuclear receptor coactivator 5

      See identical proteins and their annotated locations for NP_659141.1

      Status: VALIDATED

      Source sequence(s)
      BC017152
      Consensus CDS
      CCDS17068.1
      UniProtKB/Swiss-Prot
      A2A5L2, Q91W39
      Related
      ENSMUSP00000046388.9, ENSMUST00000040381.15
      Conserved Domains (2) summary
      COG0124
      Location:186 → 256
      HisS; Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
      PRK14971
      Location:459 → 543
      PRK14971; DNA polymerase III subunits gamma and tau; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      164842273..164876794 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006499369.5 → XP_006499432.2  nuclear receptor coactivator 5 isoform X1

      UniProtKB/TrEMBL
      B7ZC24
      Related
      ENSMUSP00000113166.2, ENSMUST00000122070.2
      Conserved Domains (1) summary
      COG0124
      Location:186 → 256
      HisS; Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]

    2. XM_030250665.1 → XP_030106525.1  nuclear receptor coactivator 5 isoform X3

      UniProtKB/TrEMBL
      B7ZC23

    3. XM_036161618.1 → XP_036017511.1  nuclear receptor coactivator 5 isoform X3

      UniProtKB/TrEMBL
      B7ZC23

    4. XM_017317897.2 → XP_017173386.1  nuclear receptor coactivator 5 isoform X2

      UniProtKB/TrEMBL
      Q8BX12
      Conserved Domains (1) summary
      COG0124
      Location:38 → 108
      HisS; Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91W39.1 GenPept UniProtKB/Swiss-Prot:Q91W39

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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