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    Gdap1l1 ganglioside-induced differentiation-associated protein 1-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 228858, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Gdap1l1provided by MGI
    Official Full Name
    ganglioside-induced differentiation-associated protein 1-like 1provided by MGI
    Primary source
    MGI:MGI:2385163
    See related
    Ensembl:ENSMUSG00000017943 AllianceGenome:MGI:2385163
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gdap1l
    Summary
    Predicted to be involved in glutathione metabolic process. Is expressed in gut; nervous system; and sensory organ. Orthologous to human GDAP1L1 (ganglioside induced differentiation associated protein 1 like 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in whole brain E14.5 (RPKM 31.9), CNS E18 (RPKM 31.4) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 H3; 2 84.28 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (163280387..163297264)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (163438420..163455324)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene junctophilin 2 Neighboring gene VISTA enhancer mm1646 Neighboring gene predicted gene, 35750 Neighboring gene STARR-seq mESC enhancer starr_06306 Neighboring gene STARR-seq mESC enhancer starr_06307 Neighboring gene STARR-positive B cell enhancer ABC_E2651 Neighboring gene RIKEN cDNA 2900093K20 gene Neighboring gene STARR-positive B cell enhancer ABC_E1608 Neighboring gene oxidative stress responsive serine rich 1 Neighboring gene STARR-seq mESC enhancer starr_06310 Neighboring gene RIKEN cDNA 2310001K24 gene Neighboring gene STARR-positive B cell enhancer ABC_E4516 Neighboring gene fat storage-inducing transmembrane protein 2 Neighboring gene hepatic nuclear factor 4 alpha, opposite strand Neighboring gene R3H domain containing-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Psoriasiform Inflammation Is Associated with Mitochondrial Fission/GDAP1L1 Signaling in Macrophages. Alalaiwe A, et al. Int J Mol Sci, 2021 Sep 27. PMID 34638757, Free PMC Article
    2. Identification of transcripts with enriched expression in the developing and adult pancreas. Hoffman BG, et al. Genome Biol, 2008. PMID 18554416, Free PMC Article
    3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Psoriasiform Inflammation Is Associated with Mitochondrial Fission/GDAP1L1 Signaling in Macrophages.
      Title: Psoriasiform Inflammation Is Associated with Mitochondrial Fission/GDAP1L1 Signaling in Macrophages.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC28116

    General protein information

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    Preferred Names
    ganglioside-induced differentiation-associated protein 1-like 1
    Names
    GDAP1-L1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001406429.1 → NP_001393358.1  ganglioside-induced differentiation-associated protein 1-like 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL591488

    2. NM_144891.3 → NP_659140.2  ganglioside-induced differentiation-associated protein 1-like 1 isoform 1

      See identical proteins and their annotated locations for NP_659140.2

      Status: VALIDATED

      Source sequence(s)
      AL591488
      Consensus CDS
      CCDS50791.1
      UniProtKB/Swiss-Prot
      A2A5I0, Q8VE33
      UniProtKB/TrEMBL
      Q3USC7
      Related
      ENSMUSP00000018087.7, ENSMUST00000018087.13
      Conserved Domains (3) summary
      COG0625
      Location:47 → 314
      GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
      cd03052
      Location:47 → 119
      GST_N_GDAP1; GST_N family, Ganglioside-induced differentiation-associated protein 1 (GDAP1) subfamily; GDAP1 was originally identified as a highly expressed gene at the differentiated stage of GD3 synthase-transfected cells. More recently, mutations in GDAP1 have ...
      cl02776
      Location:201 → 311
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

    RNA

    1. NR_153379.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AK140488, AK141371

    2. NR_176072.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL591488

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      163280387..163297264
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VE33.1 GenPept UniProtKB/Swiss-Prot:Q8VE33

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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