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    Btbd3 BTB domain containing 3 [ Mus musculus (house mouse) ]

    Gene ID: 228662, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Btbd3provided by MGI
    Official Full Name
    BTB domain containing 3provided by MGI
    Primary source
    MGI:MGI:2385155
    See related
    Ensembl:ENSMUSG00000062098 AllianceGenome:MGI:2385155
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0952
    Summary
    Predicted to enable identical protein binding activity. Involved in cerebral cortex development and dendrite morphogenesis. Located in cytosol and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and paravertebral ganglion. Orthologous to human BTBD3 (BTB domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in cerebellum adult (RPKM 49.2), frontal lobe adult (RPKM 24.9) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 F3; 2 68.28 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (138098478..138129344)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (138256584..138287424)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 52596 Neighboring gene predicted gene 14062 Neighboring gene STARR-seq mESC enhancer starr_05817 Neighboring gene STARR-seq mESC enhancer starr_05818 Neighboring gene STARR-seq mESC enhancer starr_05819 Neighboring gene STARR-seq mESC enhancer starr_05820 Neighboring gene STARR-seq mESC enhancer starr_05821 Neighboring gene STARR-seq mESC enhancer starr_05822 Neighboring gene STARR-seq mESC enhancer starr_05823 Neighboring gene STARR-seq mESC enhancer starr_05824 Neighboring gene predicted gene, 50497 Neighboring gene STARR-seq mESC enhancer starr_05825 Neighboring gene predicted gene, 54118

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Btbd3 expression regulates compulsive-like and exploratory behaviors in mice. Thompson SL, et al. Transl Psychiatry, 2019 Sep 9. PMID 31501410, Free PMC Article
    2. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. Matsui A, et al. Science, 2013 Nov 29. PMID 24179155
    3. Hoxa2 Selects Barrelette Neuron Identity and Connectivity in the Mouse Somatosensory Brainstem. Bechara A, et al. Cell Rep, 2015 Oct 27. PMID 26489473
    4. Thalamocortical axons control the cytoarchitecture of neocortical layers by area-specific supply of VGF. Sato H, et al. Elife, 2022 Mar 15. PMID 35289744, Free PMC Article
    5. Radial glia fibers translate Fgf8 morphogenetic signals to generate a thalamic nuclear complex protomap in the mantle layer. Botella-López A, et al. Brain Struct Funct, 2019 Mar. PMID 30470893, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (4) 
    • Endonuclease-mediated (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC25591

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cerebral cortex development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cerebral cortex development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dendrite morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dendrite morphogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neurogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    BTB/POZ domain-containing protein 3
    Names
    BTB (POZ) domain containing 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025431.1 → NP_001020602.1  BTB/POZ domain-containing protein 3 isoform 2

      See identical proteins and their annotated locations for NP_001020602.1

      Status: VALIDATED

      Source sequence(s)
      AK052530, BC062968, BY012054
      Consensus CDS
      CCDS16799.1
      UniProtKB/TrEMBL
      Q3TSN9, Q8CHC1
      Related
      ENSMUSP00000089144.6, ENSMUST00000091556.12
      Conserved Domains (3) summary
      cd18348
      Location:38 → 168
      BTB_POZ_BTBD3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 3 (BTBD3)
      cd18524
      Location:159 → 253
      BACK_BTBD3; BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 3 (BTBD3)
      pfam08005
      Location:315 → 460
      PHR; PHR domain

    2. NM_145534.2 → NP_663509.2  BTB/POZ domain-containing protein 3 isoform 1

      See identical proteins and their annotated locations for NP_663509.2

      Status: VALIDATED

      Source sequence(s)
      AB093275, BC062968
      Consensus CDS
      CCDS16798.1
      UniProtKB/Swiss-Prot
      P58545, Q6P5B8
      UniProtKB/TrEMBL
      Q8CHC1
      Related
      ENSMUSP00000074864.5, ENSMUST00000075410.5
      Conserved Domains (4) summary
      smart00225
      Location:129 → 228
      BTB; Broad-Complex, Tramtrack and Bric a brac
      smart00875
      Location:234 → 340
      BACK; BTB And C-terminal Kelch
      pfam00651
      Location:121 → 224
      BTB; BTB/POZ domain
      pfam08005
      Location:385 → 528
      PHR; PHR domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      138098478..138129344
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030250517.2 → XP_030106377.1  BTB/POZ domain-containing protein 3 isoform X1

      Conserved Domains (3) summary
      cl38908
      Location:1 → 78
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      pfam08005
      Location:225 → 370
      PHR; PHR domain
      cl28903
      Location:69 → 163
      BACK; BACK (BTB and C-terminal Kelch) domain

    2. XM_006499294.3 → XP_006499357.1  BTB/POZ domain-containing protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006499357.1

      Conserved Domains (3) summary
      cl38908
      Location:1 → 78
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      pfam08005
      Location:225 → 370
      PHR; PHR domain
      cl28903
      Location:69 → 163
      BACK; BACK (BTB and C-terminal Kelch) domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P58545.2 GenPept UniProtKB/Swiss-Prot:P58545

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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