Mavs mitochondrial antiviral signaling protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mavsprovided by MGI
Official Full Name: mitochondrial antiviral signaling proteinprovided by MGI
Primary source: MGI:MGI:2444773
See related: Ensembl:ENSMUSG00000037523 AllianceGenome:MGI:2444773
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Visa; IPS-1; cardif; D430028G21Rik
Summary: Enables signaling adaptor activity. Involved in several processes, including negative regulation of viral genome replication; positive regulation of myeloid dendritic cell cytokine production; and regulation of peroxisome organization. Acts upstream of or within RIG-I signaling pathway; positive regulation of defense response to virus by host; and positive regulation of type I interferon production. Located in mitochondrion and peroxisome. Orthologous to human MAVS (mitochondrial antiviral signaling protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in liver adult (RPKM 50.6), kidney adult (RPKM 46.8) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 F1; 2 63.3 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (131075445..131089945)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (131234063..131248025)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MAVS promotes interferon signaling in RNA virus infection by ZUFSP-mediated chromatin regulation.
Title: MAVS promotes interferon signaling in RNA virus infection by ZUFSP-mediated chromatin regulation.
The aldehyde dehydrogenase ALDH1B1 exerts antiviral effects through the aggregation of the adaptor MAVS.
Title: The aldehyde dehydrogenase ALDH1B1 exerts antiviral effects through the aggregation of the adaptor MAVS.
3beta-hydroxysteroid-Delta24 reductase dampens anti-viral innate immune responses by targeting K27 ubiquitination of MAVS and STING.
Title: 3β-hydroxysteroid-Δ24 reductase dampens anti-viral innate immune responses by targeting K27 ubiquitination of MAVS and STING.
MAVS-loaded unanchored Lys63-linked polyubiquitin chains activate the RIG-I-MAVS signaling cascade.
Title: MAVS-loaded unanchored Lys63-linked polyubiquitin chains activate the RIG-I-MAVS signaling cascade.
MAVS integrates glucose metabolism and RIG-I-like receptor signaling.
Title: MAVS integrates glucose metabolism and RIG-I-like receptor signaling.
MAVS Positively Regulates Mitochondrial Integrity and Metabolic Fitness in B Cells.
Title: MAVS Positively Regulates Mitochondrial Integrity and Metabolic Fitness in B Cells.
WDR77 inhibits prion-like aggregation of MAVS to limit antiviral innate immune response.
Title: WDR77 inhibits prion-like aggregation of MAVS to limit antiviral innate immune response.
MAVS signaling is required for preventing persistent chikungunya heart infection and chronic vascular tissue inflammation.
Title: MAVS signaling is required for preventing persistent chikungunya heart infection and chronic vascular tissue inflammation.
Adar1 deletion causes degeneration of the exocrine pancreas via Mavs-dependent interferon signaling.
Title: Adar1 deletion causes degeneration of the exocrine pancreas via Mavs-dependent interferon signaling.
BAG6 negatively regulates the RLR signaling pathway by targeting VISA/MAVS.
Title: BAG6 negatively regulates the RLR signaling pathway by targeting VISA/MAVS.

Submit: New GeneRIF Correction See all GeneRIFs (104)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (7) 1 citation
Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:234535

RH139303 (e-PCR)
- UniSTS:221389

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables CARD domain binding	ISO Inferred from Sequence Orthology more info
enables RIG-I binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables molecular condensate scaffold activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables signaling adaptor activity	IDA Inferred from Direct Assay more info	PubMed
enables signaling adaptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables signaling adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within RIG-I signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in activation of innate immune response	ISO Inferred from Sequence Orthology more info
involved_in antiviral innate immune response	ISO Inferred from Sequence Orthology more info
involved_in cellular response to exogenous dsRNA	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to interferon-beta	ISO Inferred from Sequence Orthology more info	PubMed
involved_in cytoplasmic pattern recognition receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in defense response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in defense response to virus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_positive_effect innate immune response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of type I interferon-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of viral genome replication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of viral genome replication	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of IP-10 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NLRP3 inflammasome complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of NLRP3 inflammasome complex assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chemokine (C-C motif) ligand 5 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of defense response to virus by host	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of defense response to virus by host	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of interferon-alpha production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interferon-alpha production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of interferon-beta production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interferon-beta production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of interleukin-6 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of myeloid dendritic cell cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of protein homodimerization activity	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of protein import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of response to cytokine stimulus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of type I interferon production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of type I interferon production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type I interferon-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in protein localization to mitochondrion	IDA Inferred from Direct Assay more info	PubMed
involved_in protein localization to mitochondrion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein tetramerization	ISO Inferred from Sequence Orthology more info	PubMed
involved_in regulation of peroxisome organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of peroxisome organization	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial membrane	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial outer membrane	TAS Traceable Author Statement more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in peroxisomal membrane	ISO Inferred from Sequence Orthology more info
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: mitochondrial antiviral-signaling protein

Names: CARD adapter inducing interferon beta; IFN-beta promoter stimulator-1; interferon beta promoter stimulator protein 1; mitochondrial anti-viral signaling protein; virus-induced signaling adapter

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001206382.1 → NP_001193311.1 mitochondrial antiviral-signaling protein isoform 2

See identical proteins and their annotated locations for NP_001193311.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, and initiates translation at a downstream, in-frame start codon, compared to variant 1. Variants 3 and 4 encode the same isoform (2), which has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AK153748, AL808128

UniProtKB/TrEMBL

Q3U5B1
NM_001206383.1 → NP_001193312.1 mitochondrial antiviral-signaling protein isoform 2

See identical proteins and their annotated locations for NP_001193312.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. Variants 3 and 4 encode the same isoform (2), which has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AL808128

UniProtKB/TrEMBL

Q3U5B1
NM_001206385.1 → NP_001193314.1 mitochondrial antiviral-signaling protein isoform 1

See identical proteins and their annotated locations for NP_001193314.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (1).

Source sequence(s)

AK028421, AK153748, AL808128

Consensus CDS

CCDS16760.1

UniProtKB/Swiss-Prot

Q8VCF0

Related

ENSMUSP00000038339.6, ENSMUST00000041362.12

Conserved Domains (1) summary

cd08811
Location:3 → 93

CARD_IPS1; Caspase activation and recruitment domain (CARD) found in IPS-1
NM_144888.2 → NP_659137.1 mitochondrial antiviral-signaling protein isoform 1

See identical proteins and their annotated locations for NP_659137.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1 and 2 encode the same isoform (1).

Source sequence(s)

AL808128

Consensus CDS

CCDS16760.1

UniProtKB/Swiss-Prot

Q8VCF0

Related

ENSMUSP00000105828.3, ENSMUST00000110199.3

Conserved Domains (1) summary

cd08811
Location:3 → 93

CARD_IPS1; Caspase activation and recruitment domain (CARD) found in IPS-1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

131075445..131089945

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036161358.1 → XP_036017251.1 mitochondrial antiviral-signaling protein isoform X1

UniProtKB/TrEMBL

Q3U5B1
XM_036161359.1 → XP_036017252.1 mitochondrial antiviral-signaling protein isoform X1

UniProtKB/TrEMBL

Q3U5B1