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    Arhgap11a Rho GTPase activating protein 11A [ Mus musculus (house mouse) ]

    Gene ID: 228482, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Arhgap11aprovided by MGI
    Official Full Name
    Rho GTPase activating protein 11Aprovided by MGI
    Primary source
    MGI:MGI:2444300
    See related
    Ensembl:ENSMUSG00000041219 AllianceGenome:MGI:2444300
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0013; 6530401L14Rik
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in signal transduction. Predicted to be located in mitochondrial matrix and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Orthologous to several human genes including ARHGAP11A (Rho GTPase activating protein 11A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E11.5 (RPKM 20.9), liver E14 (RPKM 13.4) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Arhgap11a in Genome Data Viewer
    Location:
    2 E4; 2 57.47 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (113661837..113679006, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (113831492..113848661, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 46756 Neighboring gene secretogranin V Neighboring gene STARR-positive B cell enhancer mm9_chr2:113664128-113664429 Neighboring gene STARR-seq mESC enhancer starr_05402 Neighboring gene predicted gene, 30985 Neighboring gene predicted gene, 21596

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Subcellular mRNA localization and local translation of Arhgap11a in radial glial progenitors regulates cortical development. Pilaz LJ, et al. Neuron, 2023 Mar 15. PMID 36924763, Free PMC Article
    2. Analysis of a new allele of limb deformity (ld) reveals tissue- and age-specific transcriptional effects of the Ld Global Control Region. Pavel E, et al. Int J Dev Biol, 2007. PMID 17554679
    3. Expression of human-specific ARHGAP11B in mice leads to neocortex expansion and increased memory flexibility. Xing L, et al. EMBO J, 2021 Jul 1. PMID 33938018, Free PMC Article
    4. Gene expression analysis of the embryonic subplate. Oeschger FM, et al. Cereb Cortex, 2012 Jun. PMID 21862448, Free PMC Article
    5. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ArhGAP11A mediates amyloid-beta generation and neuropathology in an Alzheimer's disease-like mouse model.
      Title: ArhGAP11A mediates amyloid-β generation and neuropathology in an Alzheimer's disease-like mouse model.
    2. Subcellular mRNA localization and local translation of Arhgap11a in radial glial progenitors regulates cortical development.
      Title: Subcellular mRNA localization and local translation of Arhgap11a in radial glial progenitors regulates cortical development.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    rho GTPase-activating protein 11A
    Names
    GAP (1-12)
    rho-type GTPase-activating protein 11A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_181416.3 → NP_852081.2  rho GTPase-activating protein 11A

      See identical proteins and their annotated locations for NP_852081.2

      Status: VALIDATED

      Source sequence(s)
      AL772405, BC058105, BU052980
      Consensus CDS
      CCDS16562.1
      UniProtKB/Swiss-Prot
      A2AL17, Q6ZQL1, Q80Y19
      Related
      ENSMUSP00000099604.2, ENSMUST00000102545.8
      Conserved Domains (2) summary
      cd04394
      Location:46 → 246
      RhoGAP-ARHGAP11A; RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP11A-like proteins. The mouse homolog of human ArhGAP11A has been detected as a gene exclusively expressed in immature ganglion cells, potentially playing ...
      pfam16609
      Location:371 → 464
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      113661837..113679006 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80Y19.2 GenPept UniProtKB/Swiss-Prot:Q80Y19

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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