U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Tnks1bp1 tankyrase 1 binding protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 228140, updated on 5-Mar-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Tnks1bp1provided by MGI
    Official Full Name
    tankyrase 1 binding protein 1provided by MGI
    Primary source
    MGI:MGI:2446193
    See related
    Ensembl:ENSMUSG00000033955 AllianceGenome:MGI:2446193
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tab182; mKIAA1741
    Summary
    Predicted to enable ankyrin repeat binding activity and enzyme binding activity. Predicted to be involved in cellular response to ionizing radiation; double-strand break repair; and positive regulation of protein phosphorylation. Predicted to be located in several cellular components, including actin cytoskeleton; adherens junction; and plasma membrane. Predicted to be part of CCR4-NOT complex. Predicted to be active in heterochromatin and nucleus. Orthologous to human TNKS1BP1 (tankyrase 1 binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in lung adult (RPKM 19.5), colon adult (RPKM 15.5) and 28 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    2 D; 2 49.45 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (84878356..84903392)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (85048013..85073048)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene proteoglycan 3 Neighboring gene purinergic receptor P2X, ligand-gated ion channel, 3 Neighboring gene STARR-positive B cell enhancer ABC_E225 Neighboring gene structure specific recognition protein 1 Neighboring gene RIKEN cDNA 4930443O20 gene Neighboring gene STARR-seq mESC enhancer starr_05013 Neighboring gene apelin receptor

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Phosphoproteomic analysis of the developing mouse brain. Ballif BA, et al. Mol Cell Proteomics, 2004 Nov. PMID 15345747
    2. Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations. Munton RP, et al. Mol Cell Proteomics, 2007 Feb. PMID 17114649
    3. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
    4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ankyrin repeat binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to ionizing radiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to ionizing radiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in double-strand break repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in double-strand break repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of peptidyl-threonine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of CCR4-NOT complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in adherens junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    part_of heterochromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of heterochromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    182 kDa tankyrase-1-binding protein

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081260.2 → NP_001074729.1  182 kDa tankyrase-1-binding protein

      See identical proteins and their annotated locations for NP_001074729.1

      Status: VALIDATED

      Source sequence(s)
      BC058639, BY023631, CB723061, CF733903
      Consensus CDS
      CCDS38166.1
      UniProtKB/Swiss-Prot
      A2BH84, P58871, Q6ZPI8
      UniProtKB/TrEMBL
      B9EKJ7
      Related
      ENSMUSP00000107232.3, ENSMUST00000111605.9
      Conserved Domains (2) summary
      PHA03247
      Location:26 → 700
      PHA03247; large tegument protein UL36; Provisional
      pfam15327
      Location:1549 → 1712
      Tankyrase_bdg_C; Tankyrase binding protein C terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      84878356..84903392
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017317616.3 → XP_017173105.1  182 kDa tankyrase-1-binding protein isoform X2

      UniProtKB/Swiss-Prot
      A2BH84, P58871, Q6ZPI8
      UniProtKB/TrEMBL
      B9EKJ7
      Conserved Domains (2) summary
      PHA03247
      Location:26 → 700
      PHA03247; large tegument protein UL36; Provisional
      pfam15327
      Location:1549 → 1712
      Tankyrase_bdg_C; Tankyrase binding protein C terminal domain

    2. XM_030250197.2 → XP_030106057.1  182 kDa tankyrase-1-binding protein isoform X2

      UniProtKB/Swiss-Prot
      A2BH84, P58871, Q6ZPI8
      UniProtKB/TrEMBL
      B9EKJ7
      Conserved Domains (2) summary
      PHA03247
      Location:26 → 700
      PHA03247; large tegument protein UL36; Provisional
      pfam15327
      Location:1549 → 1712
      Tankyrase_bdg_C; Tankyrase binding protein C terminal domain

    3. XM_006499211.4 → XP_006499274.1  182 kDa tankyrase-1-binding protein isoform X1

      See identical proteins and their annotated locations for XP_006499274.1

      UniProtKB/TrEMBL
      B9EKJ7
      Conserved Domains (2) summary
      PHA03247
      Location:26 → 706
      PHA03247; large tegument protein UL36; Provisional
      pfam15327
      Location:1554 → 1718
      Tankyrase_bdg_C; Tankyrase binding protein C terminal domain

    4. XM_006499214.4 → XP_006499277.1  182 kDa tankyrase-1-binding protein isoform X1

      See identical proteins and their annotated locations for XP_006499277.1

      UniProtKB/TrEMBL
      B9EKJ7
      Conserved Domains (2) summary
      PHA03247
      Location:26 → 706
      PHA03247; large tegument protein UL36; Provisional
      pfam15327
      Location:1554 → 1718
      Tankyrase_bdg_C; Tankyrase binding protein C terminal domain

    5. XM_006499213.5 → XP_006499276.1  182 kDa tankyrase-1-binding protein isoform X1

      See identical proteins and their annotated locations for XP_006499276.1

      UniProtKB/TrEMBL
      B9EKJ7
      Conserved Domains (2) summary
      PHA03247
      Location:26 → 706
      PHA03247; large tegument protein UL36; Provisional
      pfam15327
      Location:1554 → 1718
      Tankyrase_bdg_C; Tankyrase binding protein C terminal domain

    6. XM_030250196.2 → XP_030106056.1  182 kDa tankyrase-1-binding protein isoform X2

      UniProtKB/Swiss-Prot
      A2BH84, P58871, Q6ZPI8
      UniProtKB/TrEMBL
      B9EKJ7
      Conserved Domains (2) summary
      PHA03247
      Location:26 → 700
      PHA03247; large tegument protein UL36; Provisional
      pfam15327
      Location:1549 → 1712
      Tankyrase_bdg_C; Tankyrase binding protein C terminal domain

    7. XM_006499215.5 → XP_006499278.1  182 kDa tankyrase-1-binding protein isoform X1

      See identical proteins and their annotated locations for XP_006499278.1

      UniProtKB/TrEMBL
      B9EKJ7
      Conserved Domains (2) summary
      PHA03247
      Location:26 → 706
      PHA03247; large tegument protein UL36; Provisional
      pfam15327
      Location:1554 → 1718
      Tankyrase_bdg_C; Tankyrase binding protein C terminal domain

    8. XM_036161180.1 → XP_036017073.1  182 kDa tankyrase-1-binding protein isoform X2

      UniProtKB/Swiss-Prot
      A2BH84, P58871, Q6ZPI8
      UniProtKB/TrEMBL
      B9EKJ7
      Conserved Domains (2) summary
      PHA03247
      Location:26 → 700
      PHA03247; large tegument protein UL36; Provisional
      pfam15327
      Location:1549 → 1712
      Tankyrase_bdg_C; Tankyrase binding protein C terminal domain

    9. XM_006499212.4 → XP_006499275.1  182 kDa tankyrase-1-binding protein isoform X1

      See identical proteins and their annotated locations for XP_006499275.1

      UniProtKB/TrEMBL
      B9EKJ7
      Conserved Domains (2) summary
      PHA03247
      Location:26 → 706
      PHA03247; large tegument protein UL36; Provisional
      pfam15327
      Location:1554 → 1718
      Tankyrase_bdg_C; Tankyrase binding protein C terminal domain

    10. XM_006499217.5 → XP_006499280.1  182 kDa tankyrase-1-binding protein isoform X3

      UniProtKB/TrEMBL
      Z4YJL4
      Related
      ENSMUSP00000045767.4, ENSMUST00000048400.4
      Conserved Domains (2) summary
      PHA03307
      Location:630 → 830
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam15327
      Location:873 → 1037
      Tankyrase_bdg_C; Tankyrase binding protein C terminal domain

    RNA

    1. XR_004939866.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P58871.2 GenPept UniProtKB/Swiss-Prot:P58871

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous