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    Tlk1 tousled-like kinase 1 [ Mus musculus (house mouse) ]

    Gene ID: 228012, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Tlk1provided by MGI
    Official Full Name
    tousled-like kinase 1provided by MGI
    Primary source
    MGI:MGI:2441683
    See related
    Ensembl:ENSMUSG00000041997 AllianceGenome:MGI:2441683
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4930545J15Rik
    Summary
    Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including intracellular protein transport; peptidyl-serine phosphorylation; and regulation of chromatin assembly or disassembly. Predicted to act upstream of or within cellular response to DNA damage stimulus; chromatin organization; and phosphorylation. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and hemolymphoid system gland. Orthologous to human TLK1 (tousled like kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in liver E14 (RPKM 13.5), liver E14.5 (RPKM 11.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 C2; 2 41.9 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (70542751..70656505, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (70712407..70825816, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 46745 Neighboring gene STARR-positive B cell enhancer ABC_E7823 Neighboring gene golgi reassembly stacking protein 2 Neighboring gene STARR-seq mESC enhancer starr_04765 Neighboring gene predicted gene, 38528 Neighboring gene STARR-seq mESC enhancer starr_04766 Neighboring gene STARR-seq mESC enhancer starr_04767 Neighboring gene STARR-positive B cell enhancer ABC_E11136 Neighboring gene STARR-positive B cell enhancer ABC_E10112 Neighboring gene predicted gene, 39842 Neighboring gene F-box and WD-40 domain protein 2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The circular RNA TLK1 exacerbates myocardial ischemia/reperfusion injury via targeting miR-214/RIPK1 through TNF signaling pathway. Song YF, et al. Free Radic Biol Med, 2020 Aug 1. PMID 32445866
    2. Tousled-like kinase 1 is a negative regulator of core transcription factors in murine embryonic stem cells. Lee J, et al. Sci Rep, 2018 Jan 10. PMID 29321513, Free PMC Article
    3. The radioresistance kinase TLK1B protects the cells by promoting repair of double strand breaks. Sunavala-Dossabhoy G, et al. BMC Mol Biol, 2005 Sep 12. PMID 16156902, Free PMC Article
    4. Discovery of Stromal Regulatory Networks that Suppress Ras-Sensitized Epithelial Cell Proliferation. Liu H, et al. Dev Cell, 2017 May 22. PMID 28535374, Free PMC Article
    5. The TLK1-Nek1 axis promotes prostate cancer progression. Singh V, et al. Cancer Lett, 2019 Jul 1. PMID 30928383

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tousled-like kinase 1 promotes gastric cancer progression by regulating the tumor growth factor-beta signaling pathway.
      Title: Tousled-like kinase 1 promotes gastric cancer progression by regulating the tumor growth factor-beta signaling pathway.
    2. CircTLK1 alleviates oxygen-glucose deprivation/reperfusion induced apoptosis in HK-2 cells through miR-136-5p/Bcl2 signal axis.
      Title: CircTLK1 alleviates oxygen-glucose deprivation/reperfusion induced apoptosis in HK-2 cells through miR-136-5p/Bcl2 signal axis.
    3. The circular RNA TLK1 exacerbates myocardial ischemia/reperfusion injury via targeting miR-214/RIPK1 through TNF signaling pathway.
      Title: The circular RNA TLK1 exacerbates myocardial ischemia/reperfusion injury via targeting miR-214/RIPK1 through TNF signaling pathway.
    4. our data suggest that Tlk1 negatively regulates the expression of pluripotency factors, thereby contributing to the scheduled differentiation of mouse ESCs.
      Title: Tousled-like kinase 1 is a negative regulator of core transcription factors in murine embryonic stem cells.
    5. TLK1 and TLK2 have largely redundant roles in genome maintenance.
      Title: Differential requirements for Tousled-like kinases 1 and 2 in mammalian development.
    6. present direct evidence that TLK1B can promote repair of linearized plasmids with incompatible ends that require processing prior to ligation.
      Title: TLK1B promotes repair of DSBs via its interaction with Rad9 and Asf1.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (2) 
    • Targeted (4)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of chromatin organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase tousled-like 1
    NP_001349892.1
    NP_766252.2
    XP_006499251.1
    XP_006499252.1
    XP_006499254.1
    XP_006499256.1
    XP_017173069.1
    XP_017173070.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362963.1 → NP_001349892.1  serine/threonine-protein kinase tousled-like 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL928868, BX000490
      Conserved Domains (1) summary
      cd14040
      Location:401 → 699
      STKc_TLK1; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 1

    2. NM_172664.3 → NP_766252.2  serine/threonine-protein kinase tousled-like 1 isoform 1

      See identical proteins and their annotated locations for NP_766252.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      BC051641
      Consensus CDS
      CCDS50599.1
      UniProtKB/Swiss-Prot
      Q8C0V0
      Related
      ENSMUSP00000035961.9, ENSMUST00000038584.9
      Conserved Domains (2) summary
      smart00220
      Location:467 → 734
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14040
      Location:449 → 747
      STKc_TLK1; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 1

    RNA

    1. NR_156420.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL928868, BC057369, BX000490
      Related
      ENSMUST00000135128.8

    2. NR_156421.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AK045308, BX000490
      Related
      ENSMUST00000124629.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      70542751..70656505 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006499193.2 → XP_006499256.1  serine/threonine-protein kinase tousled-like 1 isoform X3

      See identical proteins and their annotated locations for XP_006499256.1

      UniProtKB/TrEMBL
      Q6A0C1
      Conserved Domains (1) summary
      cd14040
      Location:232 → 530
      STKc_TLK1; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 1

    2. XM_006499189.4 → XP_006499252.1  serine/threonine-protein kinase tousled-like 1 isoform X2

      Conserved Domains (1) summary
      cl21453
      Location:449 → 711
      PKc_like; Protein Kinases, catalytic domain

    3. XM_006499191.3 → XP_006499254.1  serine/threonine-protein kinase tousled-like 1 isoform X3

      See identical proteins and their annotated locations for XP_006499254.1

      UniProtKB/TrEMBL
      Q6A0C1
      Conserved Domains (1) summary
      cd14040
      Location:232 → 530
      STKc_TLK1; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 1

    4. XM_006499188.5 → XP_006499251.1  serine/threonine-protein kinase tousled-like 1 isoform X1

      See identical proteins and their annotated locations for XP_006499251.1

      Conserved Domains (1) summary
      cd14040
      Location:417 → 715
      STKc_TLK1; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 1

    5. XM_017317581.1 → XP_017173070.1  serine/threonine-protein kinase tousled-like 1 isoform X3

      UniProtKB/TrEMBL
      Q6A0C1
      Conserved Domains (1) summary
      cd14040
      Location:232 → 530
      STKc_TLK1; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 1

    6. XM_017317580.3 → XP_017173069.1  serine/threonine-protein kinase tousled-like 1 isoform X3

      UniProtKB/TrEMBL
      Q6A0C1
      Conserved Domains (1) summary
      cd14040
      Location:232 → 530
      STKc_TLK1; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 1

    RNA

    1. XR_003952263.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C0V0.2 GenPept UniProtKB/Swiss-Prot:Q8C0V0

    Gene LinkOut

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