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    Slc30a4 solute carrier family 30 (zinc transporter), member 4 [ Mus musculus (house mouse) ]

    Gene ID: 22785, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Slc30a4provided by MGI
    Official Full Name
    solute carrier family 30 (zinc transporter), member 4provided by MGI
    Primary source
    MGI:MGI:1345282
    See related
    Ensembl:ENSMUSG00000005802 AllianceGenome:MGI:1345282
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    lm; Znt4; znT-4
    Summary
    Predicted to enable zinc ion transmembrane transporter activity. Acts upstream of or within zinc ion homeostasis. Predicted to be located in late endosome. Predicted to be active in plasma membrane. Is expressed in medulla oblongata basal plate mantle layer and placenta. Orthologous to human SLC30A4 (solute carrier family 30 member 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 14.9), placenta adult (RPKM 9.8) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 E5; 2 60.65 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (122523153..122544583, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (122681233..122702663, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene AFG2 AAA ATPase homolog B Neighboring gene expressed sequence AA467197 Neighboring gene microRNA 147 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:122478177-122478415 Neighboring gene STARR-seq mESC enhancer starr_05561 Neighboring gene STARR-positive B cell enhancer ABC_E10135 Neighboring gene STARR-positive B cell enhancer mm9_chr2:122493578-122493879 Neighboring gene RIKEN cDNA 4930417H01 gene Neighboring gene biogenesis of lysosomal organelles complex-1, subunit 6, pallidin, opposite strand

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ZnT4 (SLC30A4)-null ("lethal milk") mice have defects in mammary gland secretion and hallmarks of precocious involution during lactation. McCormick NH, et al. Am J Physiol Regul Integr Comp Physiol, 2016 Jan 1. PMID 26538236, Free PMC Article
    2. ZnT4 provides zinc to zinc-dependent proteins in the trans-Golgi network critical for cell function and Zn export in mammary epithelial cells. McCormick NH, et al. Am J Physiol Cell Physiol, 2012 Aug 1. PMID 22621784, Free PMC Article
    3. Mammalian zinc transporters. McMahon RJ, et al. J Nutr, 1998 Apr. PMID 9521625
    4. Induction of metallothionein by zinc in lethal milk mutant mice. Piletz JE, et al. Biochem Genet, 1982 Dec. PMID 7165696
    5. Zinc metabolism in lethal-milk mice. Otolith, lactation, and aging effects. Erway LC, et al. J Hered, 1984 Nov-Dec. PMID 6512240

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MicroRNA-30a regulates acute cerebral ischemia-induced blood-brain barrier damage through ZnT4/zinc pathway.
      Title: MicroRNA-30a regulates acute cerebral ischemia-induced blood-brain barrier damage through ZnT4/zinc pathway.
    2. Loss of ZnT4 has profound consequences on mammary epithelial cell secretion and may promote tissue remodeling in the mammary gland during early lactation.
      Title: ZnT4 (SLC30A4)-null ("lethal milk") mice have defects in mammary gland secretion and hallmarks of precocious involution during lactation.
    3. It was shown that that ZnT4 transports Zn into the trans-Golgi network, which is critical for key secretory functions of the mammary cell.
      Title: ZnT4 provides zinc to zinc-dependent proteins in the trans-Golgi network critical for cell function and Zn export in mammary epithelial cells.
    4. Expression of zinc transporter ZnT4 in mouse choroid epithelial cells suggests that the choroid plexus plays an important role in regulation of zinc homeostasis in the brain.
      Title: Dynamic zinc pools in mouse choroid plexus.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Spontaneous (1) 
    • Targeted (1) 
    • Endonuclease-mediated (4) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monoatomic cation transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in monoatomic cation transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to toxic substance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to zinc ion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within zinc export across plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in zinc ion import into lysosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in zinc ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in zinc ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in zinc ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within zinc ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in late endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    probable proton-coupled zinc antiporter SLC30A4
    Names
    lethal milk protein
    solute carrier family 30 (zinc transporter), member 4; zinc transporter 4
    solute carrier family 30 member 4
    zinc transporter 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290993.1 → NP_001277922.1  probable proton-coupled zinc antiporter SLC30A4 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
      Source sequence(s)
      AK134245, AL772253, AW125676, CO432407, CV556160
      Consensus CDS
      CCDS71131.1
      UniProtKB/TrEMBL
      A2AK40, Q3TM66
      Related
      ENSMUSP00000097056.4, ENSMUST00000099457.4
      Conserved Domains (2) summary
      TIGR01297
      Location:131 → 365
      CDF; cation diffusion facilitator family transporter
      pfam01545
      Location:130 → 284
      Cation_efflux; Cation efflux family

    2. NM_011774.3 → NP_035904.2  probable proton-coupled zinc antiporter SLC30A4 isoform a

      See identical proteins and their annotated locations for NP_035904.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AK134245, AL772253, AW125676, CO432407, CV556160
      Consensus CDS
      CCDS16667.1
      UniProtKB/Swiss-Prot
      O35149, O35154, Q3UYZ9
      UniProtKB/TrEMBL
      Q3TM66
      Related
      ENSMUSP00000005952.5, ENSMUST00000005952.11
      Conserved Domains (2) summary
      TIGR01297
      Location:123 → 414
      CDF; cation diffusion facilitator family transporter
      pfam01545
      Location:123 → 333
      Cation_efflux; Cation efflux family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      122523153..122544583 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35149.2 GenPept UniProtKB/Swiss-Prot:O35149

    Gene LinkOut

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