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    Pip5kl1 phosphatidylinositol-4-phosphate 5-kinase-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 227733, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Pip5kl1provided by MGI
    Official Full Name
    phosphatidylinositol-4-phosphate 5-kinase-like 1provided by MGI
    Primary source
    MGI:MGI:2448520
    See related
    Ensembl:ENSMUSG00000046854 AllianceGenome:MGI:2448520
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables 1-phosphatidylinositol-4-phosphate 5-kinase activity. Predicted to be involved in several processes, including negative regulation of cell migration; negative regulation of mitochondrial membrane potential; and negative regulation of protein phosphorylation. Predicted to act upstream of or within phosphorylation. Located in cell projection. Is expressed in integumental system and nervous system. Orthologous to human PIP5KL1 (phosphatidylinositol-4-phosphate 5-kinase like 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 5.8), cortex adult (RPKM 2.5) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pip5kl1 in Genome Data Viewer
    Location:
    2 B; 2 22.09 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (32465238..32473799)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (32575226..32583787)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2613 Neighboring gene estrogen-induced osteoclastogenesis regulator 1 Neighboring gene STARR-positive B cell enhancer ABC_E4435 Neighboring gene RIKEN cDNA 9430097D07 gene Neighboring gene dolichyl-phosphate mannosyltransferase subunit 2, regulatory Neighboring gene STARR-positive B cell enhancer ABC_E10095 Neighboring gene ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 Neighboring gene predicted gene, 52551 Neighboring gene predicted gene, 23369 Neighboring gene ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 Neighboring gene STARR-positive B cell enhancer ABC_E10096

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of a phosphoinositide phosphate kinase homolog. Chang JD, et al. J Biol Chem, 2004 Mar 19. PMID 14701839
    2. A large multiethnic GWAS meta-analysis of cataract identifies new risk loci and sex-specific effects. Choquet H, et al. Nat Commun, 2021 Jun 14. PMID 34127677, Free PMC Article
    3. Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling. Wilkinson B, et al. Sci Rep, 2017 Jul 13. PMID 28706196, Free PMC Article
    4. Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Miller JA, et al. Development, 2013 Nov. PMID 24154525, Free PMC Article
    5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-4-phosphate 5-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 1-phosphatidylinositol-4-phosphate 5-kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of mitochondrial membrane potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidylinositol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylinositol phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    phosphatidylinositol 4-phosphate 5-kinase-like protein 1
    Names
    PI(4)P 5-kinase-like protein 1
    PIPKH
    phosphatidylinositol phosphate kinase homolog
    ptdIns(4)P-5-kinase-like protein 1
    NP_001365949.1
    NP_001365950.1
    NP_937834.1
    XP_017172887.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001379020.1 → NP_001365949.1  phosphatidylinositol 4-phosphate 5-kinase-like protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL928710
      Conserved Domains (1) summary
      cd17304
      Location:93 → 435
      PIPKc_PIP5KL1; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in phosphatidylinositol 4-phosphate 5-kinase-like protein 1 (PIP5KL1) and similar proteins

    2. NM_001379021.1 → NP_001365950.1  phosphatidylinositol 4-phosphate 5-kinase-like protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL928710
      Conserved Domains (1) summary
      cd17304
      Location:1 → 338
      PIPKc_PIP5KL1; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in phosphatidylinositol 4-phosphate 5-kinase-like protein 1 (PIP5KL1) and similar proteins

    3. NM_198191.3 → NP_937834.1  phosphatidylinositol 4-phosphate 5-kinase-like protein 1 isoform 2

      See identical proteins and their annotated locations for NP_937834.1

      Status: VALIDATED

      Source sequence(s)
      AL928710, AY376879
      Consensus CDS
      CCDS15920.1
      UniProtKB/Swiss-Prot
      A2ASY7, A2ASY9, Q3TNU0, Q3V0C8, Q52KH3, Q6U7H8, Q8K345
      Related
      ENSMUSP00000051282.8, ENSMUST00000055304.14
      Conserved Domains (1) summary
      pfam01504
      Location:129 → 389
      PIP5K; Phosphatidylinositol-4-phosphate 5-Kinase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      32465238..32473799
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017317398.3 → XP_017172887.1  phosphatidylinositol 4-phosphate 5-kinase-like protein 1 isoform X1

      Conserved Domains (1) summary
      cl28923
      Location:299 → 543
      PIPKc; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6U7H8.1 GenPept UniProtKB/Swiss-Prot:Q6U7H8

    Gene LinkOut

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