U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Nup188 nucleoporin 188 [ Mus musculus (house mouse) ]

    Gene ID: 227699, updated on 11-Apr-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Nup188provided by MGI
    Official Full Name
    nucleoporin 188provided by MGI
    Primary source
    MGI:MGI:2446190
    See related
    Ensembl:ENSMUSG00000052533 AllianceGenome:MGI:2446190
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to be a structural constituent of nuclear pore. Predicted to be involved in RNA export from nucleus and protein import into nucleus. Predicted to act upstream of or within mRNA transport and protein transport. Predicted to be located in nucleus. Predicted to be part of nuclear pore inner ring. Orthologous to human NUP188 (nucleoporin 188). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 50.6), thymus adult (RPKM 23.1) and 27 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    2 B; 2 21.49 cM
    Exon count:
    46
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (30176419..30234278)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (30286407..30344266)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene phytanoyl-CoA dioxygenase domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E7805 Neighboring gene dolichol kinase Neighboring gene predicted gene, 39780 Neighboring gene SH3-domain GRB2-like endophilin B2 Neighboring gene mitoguardin 2

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Peering through the pore: nuclear pore complex structure, assembly, and function. Suntharalingam M, et al. Dev Cell, 2003 Jun. PMID 12791264
    2. Expressed genes in interleukin-4 treated B cells identified by cDNA representational difference analysis. Chu CC, et al. Mol Immunol, 1998 Jun. PMID 9798653
    3. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
    4. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    5. Systematic analysis of human protein complexes identifies chromosome segregation proteins. Hutchins JR, et al. Science, 2010 Apr 30. PMID 20360068, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • KIAA0169

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables structural constituent of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within mRNA transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleocytoplasmic transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nuclear pore NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of nuclear pore inner ring IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    nucleoporin NUP188
    Names
    nucleoporin NUP188 homolog

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001410239.1 → NP_001397168.1  nucleoporin NUP188 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL954388

    2. NM_001410240.1 → NP_001397169.1  nucleoporin NUP188 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL954388

    3. NM_001410241.1 → NP_001397170.1  nucleoporin NUP188 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL954388

    4. NM_001410242.1 → NP_001397171.1  nucleoporin NUP188 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL954388
      UniProtKB/TrEMBL
      A2AWI5
      Related
      ENSMUSP00000109264.3, ENSMUST00000113634.3

    5. NM_001410243.1 → NP_001397172.1  nucleoporin NUP188 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL954388
      UniProtKB/TrEMBL
      J3JSA4
      Related
      ENSMUSP00000122398.2, ENSMUST00000138666.8

    6. NM_198304.4 → NP_938046.2  nucleoporin NUP188 isoform 1

      See identical proteins and their annotated locations for NP_938046.2

      Status: VALIDATED

      Source sequence(s)
      AL954388
      Consensus CDS
      CCDS15878.1
      UniProtKB/Swiss-Prot
      Q4VA15, Q6ZQH8, Q80UL4, Q8C7A1, Q8R3F1
      Related
      ENSMUSP00000065836.6, ENSMUST00000064447.12
      Conserved Domains (1) summary
      pfam10487
      Location:31 → 941
      Nup188; Nucleoporin subcomplex protein binding to Pom34

    RNA

    1. NR_156132.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL954388

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      30176419..30234278
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030249849.1 → XP_030105709.1  nucleoporin NUP188 isoform X1

      Conserved Domains (1) summary
      pfam10487
      Location:4 → 828
      Nup188; Nucleoporin subcomplex protein binding to Pom34
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6ZQH8.2 GenPept UniProtKB/Swiss-Prot:Q6ZQH8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous