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    Spout1 SPOUT domain containing methyltransferase 1 [ Mus musculus (house mouse) ]

    Gene ID: 227695, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Spout1provided by MGI
    Official Full Name
    SPOUT domain containing methyltransferase 1provided by MGI
    Primary source
    MGI:MGI:106544
    See related
    Ensembl:ENSMUSG00000039660 AllianceGenome:MGI:106544
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CENP-32; D2Wsu81e; 9930028P05
    Summary
    Predicted to enable miRNA binding activity. Predicted to be involved in maintenance of centrosome location and production of miRNAs involved in gene silencing by miRNA. Predicted to act upstream of or within cell division and methylation. Predicted to be located in chromosome, centromeric region; cytoplasm; and cytoskeleton. Predicted to be active in kinetochore; mitotic spindle; and spindle pole centrosome. Is expressed in embryo and extraembryonic component. Orthologous to human SPOUT1 (SPOUT domain containing methyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 60.1), limb E14.5 (RPKM 21.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 B; 2 21.29 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (30063458..30068506, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (30173446..30178494, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene solute carrier family 39 (zinc transporter), member 1, pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E7803 Neighboring gene predicted gene, 31080 Neighboring gene STARR-positive B cell enhancer ABC_E2609 Neighboring gene endonuclease G Neighboring gene kynurenine aminotransferase 1 Neighboring gene predicted gene, 31201 Neighboring gene STARR-seq mESC enhancer starr_04089 Neighboring gene STARR-seq mESC enhancer starr_04090 Neighboring gene RIKEN cDNA 1700084E18 gene Neighboring gene STARR-positive B cell enhancer ABC_E7804

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Generation and characterization of endonuclease G null mice. Irvine RA, et al. Mol Cell Biol, 2005 Jan. PMID 15601850, Free PMC Article
    2. Endonuclease G is required for early embryogenesis and normal apoptosis in mice. Zhang J, et al. Proc Natl Acad Sci U S A, 2003 Dec 23. PMID 14663139, Free PMC Article
    3. Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Ko MS, et al. Hum Mol Genet, 1998 Nov. PMID 9811942
    4. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article
    5. Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Harrison SM, et al. Development, 1995 Aug. PMID 7671812

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC90552

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables miRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables miRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in maintenance of centrosome location IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maintenance of centrosome location ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in miRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in miRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_positive_effect post-transcriptional regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitotic spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in spindle pole centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle pole centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    putative methyltransferase C9orf114 homolog
    Names
    centromere protein 32
    kinetochore-associated protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172660.4 → NP_766248.3  putative methyltransferase C9orf114 homolog

      See identical proteins and their annotated locations for NP_766248.3

      Status: VALIDATED

      Source sequence(s)
      AK147162, BY289934, BY462424
      Consensus CDS
      CCDS15873.2
      UniProtKB/Swiss-Prot
      Q3UHX9, Q8BQY9
      Related
      ENSMUSP00000097793.5, ENSMUST00000100220.5
      Conserved Domains (1) summary
      pfam02598
      Location:76 → 365
      Methyltrn_RNA_3; Putative RNA methyltransferase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      30063458..30068506 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_866012.3 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_030685.1: Suppressed sequence

      Description
      NR_030685.1: This RefSeq was permanently suppressed because the transcript is incompletely processed at its 5'' end.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UHX9.1 GenPept UniProtKB/Swiss-Prot:Q3UHX9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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