Zfpm1 zinc finger protein, multitype 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zfpm1provided by MGI
Official Full Name: zinc finger protein, multitype 1provided by MGI
Primary source: MGI:MGI:1095400
See related: Ensembl:ENSMUSG00000049577 AllianceGenome:MGI:1095400
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: FOG; Fog1
Summary: Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in several processes, including embryonic hemopoiesis; heart development; and negative regulation of cell differentiation. Acts upstream of or within several processes, including myeloid cell differentiation; regulation of chemokine production; and regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and integumental system. Orthologous to human ZFPM1 (zinc finger protein, FOG family member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in duodenum adult (RPKM 90.0), small intestine adult (RPKM 68.4) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 E1; 8 70.86 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (123008595..123064601)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (122281856..122337862)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inactivation of the GATA Cofactor ZFPM1 Results in Abnormal Development of Dorsal Raphe Serotonergic Neuron Subtypes and Increased Anxiety-Like Behavior.
Title: Inactivation of the GATA Cofactor ZFPM1 Results in Abnormal Development of Dorsal Raphe Serotonergic Neuron Subtypes and Increased Anxiety-Like Behavior.
FOG1 is a member of the PR domain containing, zinc finger protein family of transcriptional regulators.
Title: The identification and structure of an N-terminal PR domain show that FOG1 is a member of the PRDM family of proteins.
the role of FOG-1 in B lymphocytes
Title: Hematopoietic overexpression of FOG1 does not affect B-cells but reduces the number of circulating eosinophils.
FOG-1 is required for the formation of all committed Mk- and E-lineage progenitors. It mediates transcriptional megakaryocyte/erythrocyte programming of HSCs as well as their subsequent Mk/E-lineage commitment.
Title: FOG-1 and GATA-1 act sequentially to specify definitive megakaryocytic and erythroid progenitors.
Disruption of the GATA1/FOG1/NuRD transcriptional system results in a complex, pleiotropic platelet defect beyond gray platelet syndrome-like macrothrombocytopenia.
Title: Pleiotropic platelet defects in mice with disrupted FOG1-NuRD interaction.
These results implicate FOG1 and 2 and CTBPs as partners of GATA proteins in the control of adipocyte proliferation and differentiation.
Title: GATA proteins work together with friend of GATA (FOG) and C-terminal binding protein (CTBP) co-regulators to control adipogenesis.
role of the hematopoietic transcription factor GATA-1, its cofactor FOG-1, and the associated chromatin remodeling complex NuRD in the developmental silencing of HBG1 and HBG2 gene expression
Title: Role of the GATA-1/FOG-1/NuRD pathway in the expression of human beta-like globin genes.
The continuous presence of GATA1, FOG1, and NuRD is required to maintain lineage fidelity throughout megakaryocyte-erythroid ontogeny.
Title: FOG1 requires NuRD to promote hematopoiesis and maintain lineage fidelity within the megakaryocytic-erythroid compartment.
Data demonstrate that sumoylation of GATA-1 K137 promotes transcriptional activation only at target genes requiring the coregulator Friend of GATA-1 (FOG-1).
Title: Controlling hematopoiesis through sumoylation-dependent regulation of a GATA factor.
Gene expression analysis in primary mutant erythroid cells and megakaryocytes revealed an essential function for NuRD during both the repression and activation of select Gata-1/Fog1 target genes.
Title: NuRD mediates activating and repressive functions of GATA-1 and FOG-1 during blood development.

Submit: New GeneRIF Correction See all GeneRIFs (26)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (6) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Zfpm1 (e-PCR), detects polymorphism
- UniSTS:547389

PMC133767P1 (e-PCR)
- UniSTS:270659

Zfpm1 (e-PCR), detects polymorphism
- UniSTS:516506

Zfpm1 (e-PCR), detects polymorphism
- UniSTS:144833

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info
enables transcription corepressor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in atrial septum morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in atrioventricular valve morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cardiac muscle tissue morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within definitive erythrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in erythrocyte differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within erythrocyte differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within erythrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within granulocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within homeostasis of number of cells	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within megakaryocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in megakaryocyte differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within megakaryocyte differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within megakaryocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitral valve formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of interleukin-4 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mast cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of protein binding	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	TAS Traceable Author Statement more info	PubMed
involved_in outflow tract morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in platelet formation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within primitive erythrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of chemokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of definitive erythrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in tricuspid valve formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ventricular septum morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of transcription regulator complex	ISO Inferred from Sequence Orthology more info
part_of transcription repressor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: zinc finger protein ZFPM1

Names: FOG-1; Friend of GATA 1; friend of GATA protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009569.4 → NP_033595.1 zinc finger protein ZFPM1

See identical proteins and their annotated locations for NP_033595.1

Status: VALIDATED

Source sequence(s)

AC121976

Consensus CDS

CCDS22733.1

UniProtKB/Swiss-Prot

O35615

Related

ENSMUSP00000058037.9, ENSMUST00000054052.15

Conserved Domains (6) summary

PHA00733
Location:332 → 387

PHA00733; hypothetical protein

PHA03247
Location:398 → 581

PHA03247; large tegument protein UL36; Provisional

PRK14951
Location:789 → 941

PRK14951; DNA polymerase III subunits gamma and tau; Provisional

sd00017
Location:308 → 327

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:319 → 344

zf-H2C2_2; Zinc-finger double domain

cd19215
Location:101 → 209

PR-SET_ZFPM1; PR-SET domain found in zinc finger protein ZFPM1 and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

123008595..123064601

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030243422.1 → XP_030099282.1 zinc finger protein ZFPM1 isoform X2

Conserved Domains (6) summary

PHA00733
Location:314 → 369

PHA00733; hypothetical protein

PHA03247
Location:380 → 563

PHA03247; large tegument protein UL36; Provisional

PRK14951
Location:771 → 923

PRK14951; DNA polymerase III subunits gamma and tau; Provisional

sd00017
Location:290 → 309

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:301 → 326

zf-H2C2_2; Zinc-finger double domain

cd19215
Location:83 → 191

PR-SET_ZFPM1; PR-SET domain found in zinc finger protein ZFPM1 and similar proteins
XM_006530851.5 → XP_006530914.1 zinc finger protein ZFPM1 isoform X1

See identical proteins and their annotated locations for XP_006530914.1

UniProtKB/Swiss-Prot

O35615

Conserved Domains (6) summary

PHA00733
Location:332 → 387

PHA00733; hypothetical protein

PHA03247
Location:398 → 581

PHA03247; large tegument protein UL36; Provisional

PRK14951
Location:789 → 941

PRK14951; DNA polymerase III subunits gamma and tau; Provisional

sd00017
Location:308 → 327

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:319 → 344

zf-H2C2_2; Zinc-finger double domain

cd19215
Location:101 → 209

PR-SET_ZFPM1; PR-SET domain found in zinc finger protein ZFPM1 and similar proteins