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    Zfp94 zinc finger protein 94 [ Mus musculus (house mouse) ]

    Gene ID: 22756, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Zfp94provided by MGI
    Official Full Name
    zinc finger protein 94provided by MGI
    Primary source
    MGI:MGI:107610
    See related
    Ensembl:ENSMUSG00000074282 AllianceGenome:MGI:107610
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in genitourinary system. Orthologous to human ZNF45 (zinc finger protein 45). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 2.5), CNS E14 (RPKM 2.3) and 28 other tissues See more
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    Genomic context

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    Location:
    7 A3; 7 10.27 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (24001129..24016091, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (24301704..24316698, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 51 pseudogene Neighboring gene predicted gene, 50477 Neighboring gene zinc finger protein 61 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:25084411-25084520 Neighboring gene predicted gene, 51470 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:25101698-25101895 Neighboring gene predicted gene 44513 Neighboring gene zinc finger protein 930 pseudogene Neighboring gene tescalcin-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Three novel spermatogenesis-specific zinc finger genes. Weissig H, et al. FEBS Lett, 2003 Jul 17. PMID 12860387
    2. Analysis of homologous XRCC1-linked zinc-finger gene families in human and mouse: evidence for orthologous genes. Shannon M, et al. Genomics, 1998 Apr 1. PMID 9570955
    3. Comparative analysis of a conserved zinc finger gene cluster on human chromosome 19q and mouse chromosome 7. Shannon M, et al. Genomics, 1996 Apr 1. PMID 8617494
    4. Detailed comparative map of human chromosome 19q and related regions of the mouse genome. Stubbs L, et al. Genomics, 1996 Aug 1. PMID 8812484
    5. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. cloning and characterization of its expression during spermatogenesis
      Title: Three novel spermatogenesis-specific zinc finger genes.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 45

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199321.1 → NP_001186250.1  zinc finger protein 45 isoform 1

      See identical proteins and their annotated locations for NP_001186250.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
      Source sequence(s)
      AC159140, AK138205
      Consensus CDS
      CCDS57524.1
      UniProtKB/TrEMBL
      E9Q6Y4
      Related
      ENSMUSP00000104075.2, ENSMUST00000108436.8
      Conserved Domains (4) summary
      COG5048
      Location:226 → 425
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:389 → 409
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:7 → 48
      KRAB; KRAB box
      pfam13465
      Location:429 → 453
      zf-H2C2_2; Zinc-finger double domain

    2. NM_009568.3 → NP_033594.1  zinc finger protein 45 isoform 2

      See identical proteins and their annotated locations for NP_033594.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon which results in the use of a downstream, in-frame, start codon, compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus when it is compared to isoform 1.
      Source sequence(s)
      AC159140, CJ174209
      Consensus CDS
      CCDS20945.1
      UniProtKB/TrEMBL
      Q61117
      Related
      ENSMUSP00000032673.9, ENSMUST00000032673.15
      Conserved Domains (4) summary
      COG5048
      Location:220 → 419
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:383 → 403
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:1 → 42
      KRAB; KRAB box
      pfam13465
      Location:423 → 447
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      24001129..24016091 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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