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    Zcchc2 zinc finger, CCHC domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 227449, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Zcchc2provided by MGI
    Official Full Name
    zinc finger, CCHC domain containing 2provided by MGI
    Primary source
    MGI:MGI:2444114
    See related
    Ensembl:ENSMUSG00000038866 AllianceGenome:MGI:2444114
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9930114B20Rik
    Summary
    Predicted to enable nucleic acid binding activity; phosphatidylinositol binding activity; and zinc ion binding activity. Predicted to be located in cytoplasm. Is expressed in metanephros; submandibular gland primordium; and thymus primordium. Orthologous to human ZCCHC2 (zinc finger CCHC-type containing 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 19.4), thymus adult (RPKM 8.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    1 E2.1; 1 49.76 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (105916929..105961807)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (105990390..106034077)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26214 Neighboring gene zinc finger protein of the cerebellum 5 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E795 Neighboring gene STARR-positive B cell enhancer ABC_E8772 Neighboring gene STARR-positive B cell enhancer ABC_E5787 Neighboring gene predicted gene 7160 Neighboring gene STARR-seq mESC enhancer starr_01847 Neighboring gene STARR-positive B cell enhancer ABC_E4340 Neighboring gene STARR-positive B cell enhancer ABC_E2556 Neighboring gene STARR-seq mESC enhancer starr_01848 Neighboring gene predicted gene, 26509 Neighboring gene STARR-seq mESC enhancer starr_01850 Neighboring gene STARR-positive B cell enhancer ABC_E9059 Neighboring gene STARR-positive B cell enhancer ABC_E2005 Neighboring gene predicted gene, 20753

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579
    2. The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase. Groh BS, et al. EMBO Rep, 2016 May. PMID 27113764, Free PMC Article
    3. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
    4. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger CCHC domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001122675.1 → NP_001116147.1  zinc finger CCHC domain-containing protein 2 isoform B

      Status: VALIDATED

      Source sequence(s)
      AK046562, AK173248, BP762779
      Consensus CDS
      CCDS48336.1
      UniProtKB/Swiss-Prot
      Q69ZB8
      Related
      ENSMUSP00000113128.2, ENSMUST00000119166.8
      Conserved Domains (2) summary
      pfam00098
      Location:1121 → 1136
      zf-CCHC; Zinc knuckle
      cl02563
      Location:341 → 433
      PX_domain; The Phox Homology domain, a phosphoinositide binding module

    2. NM_001122676.1 → NP_001116148.1  zinc finger CCHC domain-containing protein 2 isoform A

      See identical proteins and their annotated locations for NP_001116148.1

      Status: VALIDATED

      Source sequence(s)
      AK046562, AK173248, BC055760, BP762779
      Consensus CDS
      CCDS48335.1
      UniProtKB/Swiss-Prot
      Q69ZB8, Q7TNF1, Q8CB08
      Related
      ENSMUSP00000113974.2, ENSMUST00000118196.8
      Conserved Domains (2) summary
      pfam00098
      Location:1121 → 1136
      zf-CCHC; Zinc knuckle
      cl02563
      Location:341 → 433
      PX_domain; The Phox Homology domain, a phosphoinositide binding module

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      105916929..105961807
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529512.5 → XP_006529575.1  zinc finger CCHC domain-containing protein 2 isoform X1

      Conserved Domains (4) summary
      PHA03247
      Location:813 → 960
      PHA03247; large tegument protein UL36; Provisional
      pfam00098
      Location:1126 → 1141
      zf-CCHC; Zinc knuckle
      pfam17823
      Location:657 → 944
      DUF5585; Family of unknown function (DUF5585)
      cl02563
      Location:341 → 433
      PX_domain; The Phox Homology domain, a phosphoinositide binding module

    2. XM_006529516.5 → XP_006529579.1  zinc finger CCHC domain-containing protein 2 isoform X6

      Conserved Domains (4) summary
      PHA03379
      Location:739 → 1066
      PHA03379; EBNA-3A; Provisional
      pfam00098
      Location:1078 → 1093
      zf-CCHC; Zinc knuckle
      pfam17823
      Location:587 → 896
      DUF5585; Family of unknown function (DUF5585)
      cl02563
      Location:341 → 433
      PX_domain; The Phox Homology domain, a phosphoinositide binding module

    3. XM_006529514.5 → XP_006529577.1  zinc finger CCHC domain-containing protein 2 isoform X3

      Conserved Domains (4) summary
      PHA03247
      Location:785 → 932
      PHA03247; large tegument protein UL36; Provisional
      pfam00098
      Location:1098 → 1113
      zf-CCHC; Zinc knuckle
      pfam17823
      Location:629 → 916
      DUF5585; Family of unknown function (DUF5585)
      cl02563
      Location:341 → 433
      PX_domain; The Phox Homology domain, a phosphoinositide binding module

    4. XM_006529515.5 → XP_006529578.1  zinc finger CCHC domain-containing protein 2 isoform X5

      Conserved Domains (4) summary
      PHA03247
      Location:780 → 927
      PHA03247; large tegument protein UL36; Provisional
      pfam00098
      Location:1093 → 1108
      zf-CCHC; Zinc knuckle
      pfam17823
      Location:624 → 911
      DUF5585; Family of unknown function (DUF5585)
      cl02563
      Location:341 → 433
      PX_domain; The Phox Homology domain, a phosphoinositide binding module

    5. XM_030253840.2 → XP_030109700.1  zinc finger CCHC domain-containing protein 2 isoform X9

      Conserved Domains (4) summary
      PHA03379
      Location:711 → 1038
      PHA03379; EBNA-3A; Provisional
      pfam00098
      Location:1050 → 1065
      zf-CCHC; Zinc knuckle
      pfam17823
      Location:559 → 868
      DUF5585; Family of unknown function (DUF5585)
      cl02563
      Location:341 → 433
      PX_domain; The Phox Homology domain, a phosphoinositide binding module

    6. XM_006529513.5 → XP_006529576.1  zinc finger CCHC domain-containing protein 2 isoform X2

      Conserved Domains (3) summary
      PHA03247
      Location:789 → 936
      PHA03247; large tegument protein UL36; Provisional
      pfam00098
      Location:1102 → 1117
      zf-CCHC; Zinc knuckle
      pfam17823
      Location:633 → 920
      DUF5585; Family of unknown function (DUF5585)

    7. XM_030253835.2 → XP_030109695.1  zinc finger CCHC domain-containing protein 2 isoform X4

      Conserved Domains (3) summary
      PHA03247
      Location:784 → 931
      PHA03247; large tegument protein UL36; Provisional
      pfam00098
      Location:1097 → 1112
      zf-CCHC; Zinc knuckle
      pfam17823
      Location:628 → 915
      DUF5585; Family of unknown function (DUF5585)

    8. XM_006529517.5 → XP_006529580.1  zinc finger CCHC domain-containing protein 2 isoform X7

      Conserved Domains (3) summary
      PHA03247
      Location:761 → 908
      PHA03247; large tegument protein UL36; Provisional
      pfam00098
      Location:1074 → 1089
      zf-CCHC; Zinc knuckle
      pfam17823
      Location:605 → 892
      DUF5585; Family of unknown function (DUF5585)

    9. XM_006529518.5 → XP_006529581.1  zinc finger CCHC domain-containing protein 2 isoform X8

      Conserved Domains (3) summary
      PHA03247
      Location:756 → 903
      PHA03247; large tegument protein UL36; Provisional
      pfam00098
      Location:1069 → 1084
      zf-CCHC; Zinc knuckle
      pfam17823
      Location:600 → 887
      DUF5585; Family of unknown function (DUF5585)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q69ZB8.3 GenPept UniProtKB/Swiss-Prot:Q69ZB8

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