U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Slco4c1 solute carrier organic anion transporter family, member 4C1 [ Mus musculus (house mouse) ]

    Gene ID: 227394, updated on 5-Mar-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Slco4c1provided by MGI
    Official Full Name
    solute carrier organic anion transporter family, member 4C1provided by MGI
    Primary source
    MGI:MGI:2442784
    See related
    Ensembl:ENSMUSG00000040693 AllianceGenome:MGI:2442784
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    OATPX; OATP-H; oatp-R; OATP-M1; OATP4C1; PRO2176; SLC21A20; 9530051F04; C330017E21Rik
    Summary
    Predicted to enable sodium-independent organic anion transmembrane transporter activity. Predicted to be involved in sodium-independent organic anion transport. Predicted to act upstream of or within cell differentiation; ion transport; and spermatogenesis. Predicted to be located in basolateral plasma membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in several structures, including forebrain; genitourinary system; integumental system; respiratory system; and sensory organ. Orthologous to human SLCO4C1 (solute carrier organic anion transporter family member 4C1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in genital fat pad adult (RPKM 3.6), lung adult (RPKM 3.6) and 8 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    1 D; 1 47.76 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (96744918..96800027, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (96816270..96872193, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930533P14 gene Neighboring gene abhydrolase domain containing 6 pseudogene Neighboring gene STARR-seq mESC enhancer starr_01769 Neighboring gene predicted gene, 26078 Neighboring gene STARR-seq mESC enhancer starr_01771 Neighboring gene STARR-seq mESC enhancer starr_01772 Neighboring gene pluripotency-associated noncoding transcript 2 Neighboring gene solute carrier organic anion transporter family, member 6b1 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Developmental and cell type-specific expression of thyroid hormone transporters in the mouse brain and in primary brain cells. Braun D, et al. Glia, 2011 Mar. PMID 21264952
    2. Tissue distribution, ontogeny, and hormonal regulation of xenobiotic transporters in mouse kidneys. Cheng X, et al. Drug Metab Dispos, 2009 Nov. PMID 19679677, Free PMC Article
    3. FGFR2b signalling restricts lineage-flexible alveolar progenitors during mouse lung development and converges in mature alveolar type 2 cells. Jones MR, et al. Cell Mol Life Sci, 2022 Nov 29. PMID 36445537, Free PMC Article
    4. Neuronal 3',3,5-triiodothyronine (T3) uptake and behavioral phenotype of mice deficient in Mct8, the neuronal T3 transporter mutated in Allan-Herndon-Dudley syndrome. Wirth EK, et al. J Neurosci, 2009 Jul 29. PMID 19641107, Free PMC Article
    5. USP10 deubiquitinates Tau, mediating its aggregation. Wei Z, et al. Cell Death Dis, 2022 Aug 20. PMID 35987808, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables organic anion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sodium-independent organic anion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within organic anion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in organic anion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sodium-independent organic anion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    solute carrier organic anion transporter family member 4C1
    Names
    organic anion transporting polypeptide 4C1
    solute carrier family 21 member 20

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172658.3 → NP_766246.1  solute carrier organic anion transporter family member 4C1

      See identical proteins and their annotated locations for NP_766246.1

      Status: PROVISIONAL

      Source sequence(s)
      AK049253
      Consensus CDS
      CCDS35675.1
      UniProtKB/Swiss-Prot
      Q8BGD4
      Related
      ENSMUSP00000071875.5, ENSMUST00000071985.6
      Conserved Domains (3) summary
      cd06174
      Location:120 → 473
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      cd01330
      Location:496 → 549
      KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
      pfam03137
      Location:102 → 662
      OATP; Organic Anion Transporter Polypeptide (OATP) family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      96744918..96800027 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_001784188.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BGD4.1 GenPept UniProtKB/Swiss-Prot:Q8BGD4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous