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    Farp2 FERM, RhoGEF and pleckstrin domain protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 227377, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Farp2provided by MGI
    Official Full Name
    FERM, RhoGEF and pleckstrin domain protein 2provided by MGI
    Primary source
    MGI:MGI:2385126
    See related
    Ensembl:ENSMUSG00000034066 AllianceGenome:MGI:2385126
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fir; mKIAA0793; D030026M03Rik
    Summary
    Enables guanyl-nucleotide exchange factor activity. Involved in several processes, including actin cytoskeleton reorganization; osteoclast differentiation; and podosome assembly. Acts upstream of or within hair cycle process. Predicted to be located in cytoplasm. Is expressed in central nervous system and retina. Orthologous to human FARP2 (FERM, ARH/RhoGEF and pleckstrin domain protein 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in large intestine adult (RPKM 5.0), colon adult (RPKM 4.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Farp2 in Genome Data Viewer
    Location:
    1 D; 1 47.24 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (93439826..93549698)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (93512104..93621976)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene high density lipoprotein (HDL) binding protein Neighboring gene predicted gene, 17415 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:95362466-95362649 Neighboring gene STARR-positive B cell enhancer ABC_E1556 Neighboring gene STARR-positive B cell enhancer ABC_E4336 Neighboring gene septin 2 Neighboring gene STARR-positive B cell enhancer ABC_E4337 Neighboring gene STARR-positive B cell enhancer ABC_E1223 Neighboring gene STARR-seq mESC enhancer starr_01729 Neighboring gene predicted gene, 41920 Neighboring gene STARR-seq mESC enhancer starr_01730 Neighboring gene elongation factor RNA polymerase II-like 3 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:95532366-95532549 Neighboring gene serine/threonine kinase 25 (yeast) Neighboring gene BCL2-related ovarian killer Neighboring gene THAP domain containing 4 Neighboring gene STARR-seq mESC enhancer starr_01735

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Developmental regulation of FERM domain including guanine nucleotide exchange factor gene expression in the mouse brain. Kawakita A, et al. Brain Res Dev Brain Res, 2003 Sep 10. PMID 12935915
    2. Integral roles of a guanine nucleotide exchange factor, FARP2, in osteoclast podosome rearrangements. Takegahara N, et al. FASEB J, 2010 Dec. PMID 20702777
    3. Farp2 and Stk25 are candidate genes for the HDL cholesterol locus on mouse chromosome 1. Su Z, et al. Arterioscler Thromb Vasc Biol, 2009 Jan. PMID 18988887, Free PMC Article
    4. Modular and Distinct Plexin-A4/FARP2/Rac1 Signaling Controls Dendrite Morphogenesis. Danelon V, et al. J Neurosci, 2020 Jul 8. PMID 32499377, Free PMC Article
    5. Structural basis for autoinhibition of the guanine nucleotide exchange factor FARP2. He X, et al. Structure, 2013 Mar 5. PMID 23375260, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Modular and Distinct Plexin-A4/FARP2/Rac1 Signaling Controls Dendrite Morphogenesis.
      Title: Modular and Distinct Plexin-A4/FARP2/Rac1 Signaling Controls Dendrite Morphogenesis.
    2. Findings reveal an integral role of FARP2 for regulation of Rac1 and integrin beta3 throughout podosome rearrangement in osteoclastogenesis.
      Title: Integral roles of a guanine nucleotide exchange factor, FARP2, in osteoclast podosome rearrangements.
    3. Confirmed Hdlq14 as a separate independent quantitative trait locus for HDL and narrowed the region to 2 genes, Farp2 and Stk25, with considerable evidence for both.
      Title: Farp2 and Stk25 are candidate genes for the HDL cholesterol locus on mouse chromosome 1.
    4. Developmental regulation of FERM domain including guanine nucleotide exchange factor gene expression in the mouse brain.
      Title: Developmental regulation of FERM domain including guanine nucleotide exchange factor gene expression in the mouse brain.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0793

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytoskeletal protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity TAS
    Traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Rac protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within hair cycle process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neuron remodeling ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in osteoclast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in podosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of integrin activation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in semaphorin-plexin signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    FERM, ARHGEF and pleckstrin domain-containing protein 2
    Names
    FERM domain including RhoGEF
    FERM, RhoGEF and pleckstrin domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145519.2 → NP_663494.2  FERM, ARHGEF and pleckstrin domain-containing protein 2

      See identical proteins and their annotated locations for NP_663494.2

      Status: VALIDATED

      Source sequence(s)
      AK050860, AK173028, AW912106, BB663505, BI739824, BP770314, BY130680
      Consensus CDS
      CCDS15191.1
      UniProtKB/Swiss-Prot
      E9QJS4, Q3TAP2, Q69ZZ0, Q91VS8
      Related
      ENSMUSP00000112725.2, ENSMUST00000120301.8
      Conserved Domains (9) summary
      smart00295
      Location:45 → 234
      B41; Band 4.1 homologues
      cd00160
      Location:540 → 723
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01220
      Location:752 → 859
      PH1_FARP1-like; FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins Pleckstrin Homology (PH) domain, repeat 1
      cd13193
      Location:221 → 341
      FERM_C_FARP1-like; FERM domain C-lobe of FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins
      cd13235
      Location:929 → 1026
      PH2_FARP1-like; FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins Pleckstrin Homology (PH) domain, repeat 2
      pfam00169
      Location:934 → 1027
      PH; PH domain
      pfam00373
      Location:131 → 234
      FERM_M; FERM central domain
      pfam08736
      Location:333 → 375
      FA; FERM adjacent (FA)
      pfam09379
      Location:48 → 111
      FERM_N; FERM N-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      93439826..93549698
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91VS8.2 GenPept UniProtKB/Swiss-Prot:Q91VS8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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